Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Northwestern State (294) | 59 | 77 | Oklahoma (37) | Final | L | -18 |
| 2 | 2021-11-10 | Northwestern State (294) | 75 | 82 | Tulsa (127) | Final | L | -7 |
| 3 | 2021-11-13 | Champion Christian | 62 | 91 | Northwestern State (294) | Final | W | 29 |
| 4 | 2021-11-15 | Northwestern State (306) | 48 | 95 | SMU (179) | Final | L | -47 |
| 5 | 2021-11-19 | Louisiana Tech (185) | 83 | 64 | Northwestern State (315) | Final | L | -19 |
| 6 | 2021-11-22 | Northwestern State (315) | 66 | 96 | Louisiana-Monroe (358) | Final | L | -30 |
| 7 | 2021-11-28 | Stephen F. Austin (149) | 72 | 68 | Northwestern State (347) | Final | L | -4 |
| 8 | 2021-11-30 | Northwestern State (347) | 58 | 99 | Houston (19) | Final | L | -41 |
| 9 | 2021-12-04 | Northwestern State (315) | 71 | 84 | Louisiana-Monroe (358) | Final | L | -13 |
| 10 | 2021-12-11 | Dallas Christian | 67 | 89 | Northwestern State (315) | Final | W | 22 |
| 11 | 2021-12-14 | Northwestern State (315) | 49 | 89 | LSU (77) | Final | L | -40 |
| 12 | 2021-12-18 | Southwestern Adventist | 50 | 104 | Northwestern State (315) | Final | W | 54 |
| 13 | 2021-12-21 | Northwestern State (315) | 61 | 80 | Texas A&M (39) | Final | L | -19 |
| 14 | 2021-12-28 | Northwestern State (315) | 68 | 104 | Baylor (58) | Final | L | -36 |
| 15 | 2022-01-06 | Northwestern State (315) | 67 | 89 | Texas A&M-Corpus Christi (208) | Final | L | -22 |
| 16 | 2022-01-07 | Northwestern State (315) | 83 | 80 | Incarnate Word (280) | Final | W | 3 |
| 17 | 2022-01-08 | New Orleans (236) | 80 | 79 | Northwestern State (315) | Final | L | -1 |
| 18 | 2022-01-15 | Northwestern State (315) | 74 | 79 | Southeastern Louisiana (318) | Final | L | -5 |
| 19 | 2022-01-20 | Northwestern State (315) | 58 | 69 | Nicholls State (250) | Final | L | -11 |
| 20 | 2022-01-22 | Northwestern State (315) | 77 | 85 | New Orleans (236) | Final | L | -8 |
| 21 | 2022-01-27 | Incarnate Word (280) | 70 | 79 | Northwestern State (315) | Final | W | 9 |
| 22 | 2022-01-29 | Texas A&M-Corpus Christi (208) | 76 | 90 | Northwestern State (315) | Final | W | 14 |
| 23 | 2022-02-03 | Northwestern State (315) | 97 | 87 | Houston Christian (305) | Final | W | 10 |
| 24 | 2022-02-03 | Northwestern State (331) | 97 | 87 | Houston Baptist (338) | Final | W | 10 |
| 25 | 2022-02-05 | Northwestern State (315) | 84 | 93 | McNeese (63) | Final | L | -9 |
| 26 | 2022-02-05 | Northwestern State (331) | 84 | 93 | McNeese State (288) | Final | L | -9 |
| 27 | 2022-02-10 | Houston Baptist (333) | 76 | 69 | Northwestern State (319) | Final | L | -7 |
| 28 | 2022-02-12 | McNeese State (289) | 80 | 75 | Northwestern State (319) | Final | L | -5 |
| 29 | 2022-02-17 | Northwestern State (315) | 88 | 64 | Incarnate Word (280) | Final | W | 24 |
| 30 | 2022-02-19 | Northwestern State (335) | 76 | 83 | Texas A&M-Corpus Christi (247) | Final | L | -7 |
| 31 | 2022-02-24 | Nicholls State (199) | 80 | 62 | Northwestern State (331) | Final | L | -18 |
| 32 | 2022-02-26 | New Orleans (212) | 77 | 87 | Northwestern State (331) | Final | W | 10 |
| 33 | 2022-03-05 | Southeastern Louisiana (250) | 85 | 80 | Northwestern State (326) | Final | L | -5 |
| 34 | 2022-03-09 | McNeese State (312) | 80 | 67 | Northwestern State (332) | Final | L | -13 |