Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina State (345) | 62 | 70 | East Carolina (170) | Final | W | 8 |
| 2 | 2021-11-12 | Canisius (328) | 71 | 83 | East Carolina (252) | Final | W | 12 |
| 3 | 2021-11-14 | Western Carolina (223) | 79 | 95 | East Carolina (252) | Final | W | 16 |
| 4 | 2021-11-18 | Oklahoma (28) | 79 | 74 | East Carolina (69) | Final | L | -5 |
| 5 | 2021-11-19 | East Carolina (252) | 73 | 60 | Old Dominion (254) | Final | W | 13 |
| 6 | 2021-11-21 | Davidson (80) | 76 | 67 | East Carolina (132) | Final | L | -9 |
| 7 | 2021-11-27 | Coppin State (341) | 68 | 70 | East Carolina (132) | Final | W | 2 |
| 8 | 2021-11-30 | Old Dominion (249) | 62 | 63 | East Carolina (123) | Final | W | 1 |
| 9 | 2021-12-04 | Gardner-Webb (363) | 52 | 62 | East Carolina (252) | Final | W | 10 |
| 10 | 2021-12-07 | North Carolina A&T (294) | 71 | 82 | East Carolina (252) | Final | W | 11 |
| 11 | 2021-12-17 | Liberty (93) | 74 | 64 | East Carolina (252) | Final | L | -10 |
| 12 | 2021-12-21 | Southern Miss (201) | 67 | 68 | East Carolina (252) | Final | W | 1 |
| 13 | 2021-12-29 | Wichita State (76) | 0 | 0 | East Carolina (252) | Cancelled | - | - |
| 14 | 2022-01-01 | East Carolina (252) | 0 | 0 | South Florida (52) | Postponed | - | - |
| 15 | 2022-01-05 | Tulane (167) | 80 | 88 | East Carolina (252) | Final/OT | W | 8 |
| 16 | 2022-01-08 | East Carolina (252) | 75 | 78 | Temple (169) | Final | L | -3 |
| 17 | 2022-01-12 | East Carolina (114) | 71 | 79 | Cincinnati (90) | Final | L | -8 |
| 18 | 2022-01-15 | Memphis (136) | 71 | 72 | East Carolina (252) | Final | W | 1 |
| 19 | 2022-01-18 | Central Florida (43) | 92 | 85 | East Carolina (252) | Final/OT | L | -7 |
| 20 | 2022-01-22 | East Carolina (252) | 36 | 79 | Houston (5) | Final | L | -43 |
| 21 | 2022-01-27 | East Carolina (252) | 54 | 71 | Memphis (136) | Final | L | -17 |
| 22 | 2022-01-30 | Cincinnati (73) | 60 | 59 | East Carolina (131) | Final | L | -1 |
| 23 | 2022-02-02 | Temple (96) | 71 | 63 | East Carolina (131) | Final | L | -8 |
| 24 | 2022-02-05 | East Carolina (252) | 66 | 86 | Tulane (167) | Final | L | -20 |
| 25 | 2022-02-08 | East Carolina (149) | 73 | 71 | Tulsa (200) | Final | W | 2 |
| 26 | 2022-02-12 | SMU (45) | 80 | 66 | East Carolina (252) | Final | L | -14 |
| 27 | 2022-02-17 | East Carolina (252) | 65 | 57 | South Florida (52) | Final | W | 8 |
| 28 | 2022-02-20 | East Carolina (148) | 66 | 69 | Central Florida (81) | Final | L | -3 |
| 29 | 2022-02-23 | South Florida (245) | 60 | 64 | East Carolina (148) | Final | W | 4 |
| 30 | 2022-02-26 | Tulsa (195) | 59 | 64 | East Carolina (148) | Final | W | 5 |
| 31 | 2022-03-05 | East Carolina (137) | 62 | 70 | Wichita State (100) | Final | L | -8 |
| 32 | 2022-03-10 | East Carolina (142) | 63 | 74 | Cincinnati (110) | Final | L | -11 |