Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | LeTourneau | 54 | 97 | Sam Houston State (135) | Final | W | 43 |
| 2 | 2021-11-12 | Sam Houston State (120) | 65 | 74 | Nebraska (13) | Final | L | -9 |
| 3 | 2021-11-17 | Missouri State (224) | 77 | 55 | Sam Houston State (120) | Final | L | -22 |
| 4 | 2021-11-21 | Little Rock (233) | 59 | 77 | Sam Houston State (222) | Final | W | 18 |
| 5 | 2021-11-22 | Boston University (267) | 72 | 59 | Sam Houston State (120) | Final | L | -13 |
| 6 | 2021-11-24 | Sam Houston State (120) | 66 | 75 | SMU (45) | Final | L | -9 |
| 7 | 2021-11-29 | Sam Houston State (268) | 57 | 73 | Texas (37) | Final | L | -16 |
| 8 | 2021-12-02 | Schreiner | 46 | 106 | Sam Houston State (268) | Final | W | 60 |
| 9 | 2021-12-11 | UTSA (344) | 78 | 73 | Sam Houston State (120) | Final | L | -5 |
| 10 | 2021-12-14 | Sam Houston State (120) | 55 | 65 | North Texas (125) | Final | L | -10 |
| 11 | 2021-12-18 | Hardin-Simmons | 53 | 103 | Sam Houston State (283) | Final | W | 50 |
| 12 | 2021-12-21 | Bradley (113) | 87 | 61 | Sam Houston State (120) | Final | L | -26 |
| 13 | 2021-12-22 | Sam Houston State (120) | 68 | 51 | North Carolina Central (341) | Final | W | 17 |
| 14 | 2021-12-30 | Lamar (279) | 64 | 75 | Sam Houston State (120) | Final | W | 11 |
| 15 | 2022-01-03 | UTRGV (161) | 78 | 86 | Sam Houston State (120) | Final | W | 8 |
| 16 | 2022-01-06 | Sam Houston State (120) | 64 | 75 | Tarleton State (234) | Final | L | -11 |
| 17 | 2022-01-08 | Sam Houston State (120) | 65 | 63 | Abilene Christian (245) | Final | W | 2 |
| 18 | 2022-01-13 | Sam Houston State (120) | 73 | 56 | Lamar (279) | Final | W | 17 |
| 19 | 2022-01-15 | Stephen F. Austin (88) | 41 | 49 | Sam Houston State (120) | Final | W | 8 |
| 20 | 2022-01-20 | New Mexico State (207) | 46 | 71 | Sam Houston State (120) | Final | W | 25 |
| 21 | 2022-01-22 | Grand Canyon (74) | 56 | 58 | Sam Houston State (120) | Final | W | 2 |
| 22 | 2022-01-26 | Sam Houston State (182) | 73 | 68 | California Baptist (188) | Final | W | 5 |
| 23 | 2022-01-29 | Sam Houston State (120) | 63 | 78 | Seattle (118) | Final | L | -15 |
| 24 | 2022-02-03 | Dixie State (251) | 53 | 77 | Sam Houston State (184) | Final | W | 24 |
| 25 | 2022-02-05 | Utah Valley (91) | 57 | 54 | Sam Houston State (120) | Final | L | -3 |
| 26 | 2022-02-12 | Sam Houston State (120) | 72 | 59 | Chicago State (351) | Final | W | 13 |
| 27 | 2022-02-17 | Abilene Christian (245) | 71 | 75 | Sam Houston State (120) | Final/OT | W | 4 |
| 28 | 2022-02-19 | Sam Houston State (171) | 67 | 61 | UTRGV (309) | Final | W | 6 |
| 29 | 2022-02-24 | Sam Houston State (160) | 67 | 69 | Stephen F. Austin (128) | Final | L | -2 |
| 30 | 2022-02-26 | Sam Houston State (160) | 41 | 67 | Grand Canyon (108) | Final | L | -26 |
| 31 | 2022-03-03 | Tarleton State (224) | 50 | 69 | Sam Houston State (175) | Final | W | 19 |
| 32 | 2022-03-09 | California Baptist (210) | 35 | 65 | Sam Houston State (162) | Final | W | 30 |
| 33 | 2022-03-10 | Sam Houston State (162) | 66 | 71 | Grand Canyon (94) | Final | L | -5 |