Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Mount St. Joseph | 45 | 74 | Evansville (225) | Final | W | 29 |
| 2 | 2021-11-04 | Kentucky Wesleyan | 64 | 74 | Evansville (225) | Final | W | 10 |
| 3 | 2021-11-09 | Evansville (225) | 43 | 65 | Cincinnati (97) | Final | L | -22 |
| 4 | 2021-11-11 | IUPUI (263) | 40 | 60 | Evansville (225) | Final | W | 20 |
| 5 | 2021-11-13 | Evansville (225) | 43 | 81 | Belmont (72) | Final | L | -38 |
| 6 | 2021-11-16 | DePauw | 58 | 69 | Evansville (262) | Final | W | 11 |
| 7 | 2021-11-20 | Central Florida (43) | 75 | 59 | Evansville (302) | Final | L | -16 |
| 8 | 2021-11-22 | Evansville (302) | 104 | 109 | Rice (228) | Final/3OT | L | -5 |
| 9 | 2021-11-23 | Vermont (121) | 58 | 49 | Evansville (277) | Final | L | -9 |
| 10 | 2021-11-24 | Akron (59) | 69 | 60 | Evansville (302) | Final | L | -9 |
| 11 | 2021-11-28 | Evansville (313) | 70 | 54 | Eastern Illinois (356) | Final | W | 16 |
| 12 | 2021-12-01 | Southern Illinois (150) | 54 | 52 | Evansville (302) | Final | L | -2 |
| 13 | 2021-12-04 | Tennessee Tech (310) | 51 | 59 | Evansville (302) | Final | W | 8 |
| 14 | 2021-12-08 | Evansville (280) | 73 | 75 | Southeast Missouri State (288) | Final | L | -2 |
| 15 | 2021-12-18 | Tennessee-Martin (205) | 0 | 0 | Evansville (302) | Cancelled | - | - |
| 16 | 2021-12-21 | Evansville (302) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 17 | 2022-01-02 | Evansville (302) | 61 | 83 | Northern Iowa (89) | Final | L | -22 |
| 18 | 2022-01-05 | Evansville (302) | 0 | 0 | Indiana State (243) | Postponed | - | - |
| 19 | 2022-01-08 | Drake (217) | 60 | 59 | Evansville (302) | Final | L | -1 |
| 20 | 2022-01-12 | Evansville (310) | 47 | 79 | Bradley (185) | Final | L | -32 |
| 21 | 2022-01-18 | Loyola-Chicago (263) | 77 | 48 | Evansville (302) | Final | L | -29 |
| 22 | 2022-01-21 | Evansville (318) | 56 | 94 | Illinois State (212) | Final | L | -38 |
| 23 | 2022-01-23 | Illinois State (218) | 53 | 56 | Evansville (310) | Final | W | 3 |
| 24 | 2022-01-26 | Northern Iowa (147) | 64 | 59 | Evansville (310) | Final | L | -5 |
| 25 | 2022-01-29 | Evansville (302) | 58 | 72 | Missouri State (224) | Final | L | -14 |
| 26 | 2022-02-05 | Bradley (113) | 76 | 41 | Evansville (302) | Final | L | -35 |
| 27 | 2022-02-08 | Evansville (316) | 65 | 56 | Indiana State (235) | Final | W | 9 |
| 28 | 2022-02-10 | Indiana State (243) | 80 | 77 | Evansville (302) | Final/2OT | L | -3 |
| 29 | 2022-02-12 | Evansville (302) | 62 | 69 | Southern Illinois (150) | Final | L | -7 |
| 30 | 2022-02-16 | Evansville (312) | 51 | 73 | Drake (110) | Final | L | -22 |
| 31 | 2022-02-19 | Valparaiso (212) | 72 | 56 | Evansville (312) | Final | L | -16 |
| 32 | 2022-02-21 | Evansville (318) | 69 | 74 | Valparaiso (208) | Final | L | -5 |
| 33 | 2022-02-23 | Evansville (318) | 31 | 82 | Loyola-Chicago (50) | Final | L | -51 |
| 34 | 2022-02-26 | Missouri State (98) | 88 | 79 | Evansville (318) | Final | L | -9 |
| 35 | 2022-03-03 | Evansville (322) | 59 | 81 | Valparaiso (212) | Final | L | -22 |