Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-06 | Loyola (LA) | 80 | 72 | New Orleans (293) | Final | L | -8 |
| 2 | 2021-11-09 | New Orleans (293) | 61 | 82 | Ole Miss (60) | Final | L | -21 |
| 3 | 2021-11-13 | Spring Hill | 41 | 79 | New Orleans (293) | Final | W | 38 |
| 4 | 2021-11-16 | New Orleans (228) | 67 | 83 | Northwestern (30) | Final | L | -16 |
| 5 | 2021-11-19 | Rice (228) | 83 | 78 | New Orleans (236) | Final | L | -5 |
| 6 | 2021-11-24 | Central Arkansas (143) | 63 | 90 | New Orleans (236) | Final | W | 27 |
| 7 | 2021-11-25 | Presbyterian (264) | 68 | 66 | New Orleans (236) | Final | L | -2 |
| 8 | 2021-11-26 | Virginia Military (357) | 71 | 79 | New Orleans (236) | Final | W | 8 |
| 9 | 2021-11-30 | New Orleans (238) | 65 | 85 | Texas A&M (42) | Final | L | -20 |
| 10 | 2021-12-03 | New Orleans (236) | 67 | 80 | Louisiana (290) | Final | L | -13 |
| 11 | 2021-12-11 | New Orleans (236) | 50 | 82 | Utah State (25) | Final | L | -32 |
| 12 | 2021-12-17 | Dillard | 0 | 0 | New Orleans (236) | Cancelled | - | - |
| 13 | 2021-12-21 | New Orleans (236) | 0 | 0 | Tulane (167) | Cancelled | - | - |
| 14 | 2021-12-28 | New Orleans (236) | 0 | 0 | Ohio State (34) | Cancelled | - | - |
| 15 | 2021-12-31 | Belhaven | 54 | 94 | New Orleans (236) | Final | W | 40 |
| 16 | 2022-01-06 | New Orleans (236) | 82 | 92 | McNeese (63) | Final/2OT | L | -10 |
| 17 | 2022-01-06 | New Orleans (265) | 82 | 92 | McNeese State (295) | Final (2OT) | L | -10 |
| 18 | 2022-01-07 | Houston Baptist (318) | 65 | 81 | New Orleans (265) | Final | W | 16 |
| 19 | 2022-01-08 | New Orleans (236) | 80 | 79 | Northwestern State (315) | Final | W | 1 |
| 20 | 2022-01-11 | Dillard | 66 | 93 | New Orleans (236) | Final | W | 27 |
| 21 | 2022-01-15 | Nicholls State (250) | 66 | 78 | New Orleans (236) | Final | W | 12 |
| 22 | 2022-01-20 | Southeastern Louisiana (318) | 72 | 78 | New Orleans (236) | Final | W | 6 |
| 23 | 2022-01-22 | Northwestern State (315) | 77 | 85 | New Orleans (236) | Final | W | 8 |
| 24 | 2022-01-27 | New Orleans (236) | 77 | 66 | Houston Christian (305) | Final | W | 11 |
| 25 | 2022-01-27 | New Orleans (238) | 77 | 66 | Houston Baptist (327) | Final | W | 11 |
| 26 | 2022-01-30 | New Orleans (223) | 84 | 78 | McNeese State (288) | Final | W | 6 |
| 27 | 2022-02-03 | New Orleans (236) | 79 | 70 | Texas A&M-Corpus Christi (208) | Final | W | 9 |
| 28 | 2022-02-05 | New Orleans (236) | 70 | 78 | Incarnate Word (280) | Final | L | -8 |
| 29 | 2022-02-10 | Texas A&M-Corpus Christi (208) | 69 | 78 | New Orleans (236) | Final | W | 9 |
| 30 | 2022-02-12 | Incarnate Word (280) | 57 | 84 | New Orleans (236) | Final | W | 27 |
| 31 | 2022-02-19 | McNeese State (292) | 75 | 88 | New Orleans (217) | Final | W | 13 |
| 32 | 2022-02-24 | New Orleans (212) | 79 | 84 | Southeastern Louisiana (265) | Final | L | -5 |
| 33 | 2022-02-26 | New Orleans (212) | 77 | 87 | Northwestern State (331) | Final | L | -10 |
| 34 | 2022-03-02 | Houston Baptist (327) | 74 | 75 | New Orleans (234) | Final | W | 1 |
| 35 | 2022-03-05 | New Orleans (234) | 85 | 92 | Nicholls State (201) | Final | L | -7 |
| 36 | 2022-03-10 | McNeese State (312) | 78 | 82 | New Orleans (234) | Final | W | 4 |
| 37 | 2022-03-11 | New Orleans (234) | 65 | 74 | Southeastern Louisiana (242) | Final | L | -9 |
| 38 | 2022-03-19 | New Orleans (241) | 73 | 94 | Portland (179) | Final | L | -21 |