Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Brescia | 59 | 98 | Middle Tennessee (315) | Final | W | 39 |
| 2 | 2021-11-12 | Bethune-Cookman (240) | 51 | 71 | Middle Tennessee (164) | Final | W | 20 |
| 3 | 2021-11-16 | Winthrop (118) | 65 | 76 | Middle Tennessee (110) | Final | W | 11 |
| 4 | 2021-11-19 | Middle Tennessee (164) | 74 | 87 | Stephen F. Austin (88) | Final | L | -13 |
| 5 | 2021-11-23 | Middle Tennessee (152) | 60 | 54 | Rider (308) | Final | W | 6 |
| 6 | 2021-11-24 | Middle Tennessee (164) | 82 | 58 | Mercer (174) | Final | W | 24 |
| 7 | 2021-11-27 | Bryan | 48 | 96 | Middle Tennessee (152) | Final | W | 48 |
| 8 | 2021-12-01 | Tennessee-Martin (205) | 61 | 73 | Middle Tennessee (164) | Final | W | 12 |
| 9 | 2021-12-04 | Middle Tennessee (164) | 87 | 93 | Murray State (116) | Final | L | -6 |
| 10 | 2021-12-11 | Middle Tennessee (164) | 84 | 75 | Tennessee-Martin (205) | Final | W | 9 |
| 11 | 2021-12-15 | Middle Tennessee (164) | 52 | 62 | Ole Miss (79) | Final | L | -10 |
| 12 | 2021-12-19 | Coastal Carolina (188) | 80 | 84 | Middle Tennessee (164) | Final | W | 4 |
| 13 | 2021-12-22 | Middle Tennessee (164) | 65 | 77 | Chattanooga (291) | Final | L | -12 |
| 14 | 2021-12-30 | UTSA (344) | 0 | 0 | Middle Tennessee (164) | Postponed | - | - |
| 15 | 2022-01-01 | UTEP (274) | 0 | 0 | Middle Tennessee (164) | Postponed | - | - |
| 16 | 2022-01-06 | Middle Tennessee (164) | 61 | 65 | Rice (228) | Final | L | -4 |
| 17 | 2022-01-08 | Middle Tennessee (164) | 63 | 70 | North Texas (125) | Final | L | -7 |
| 18 | 2022-01-13 | Florida Atlantic (128) | 57 | 70 | Middle Tennessee (164) | Final | W | 13 |
| 19 | 2022-01-15 | Florida International (214) | 39 | 50 | Middle Tennessee (164) | Final | W | 11 |
| 20 | 2022-01-22 | Southern Miss (201) | 60 | 74 | Middle Tennessee (164) | Final | W | 14 |
| 21 | 2022-01-27 | Middle Tennessee (164) | 81 | 79 | Marshall (155) | Final | W | 2 |
| 22 | 2022-01-29 | Middle Tennessee (164) | 93 | 85 | Western Kentucky (154) | Final | W | 8 |
| 23 | 2022-02-05 | Middle Tennessee (164) | 75 | 97 | UAB (115) | Final | L | -22 |
| 24 | 2022-02-07 | UTSA (344) | 75 | 84 | Middle Tennessee (164) | Final | W | 9 |
| 25 | 2022-02-10 | Old Dominion (254) | 48 | 63 | Middle Tennessee (164) | Final | W | 15 |
| 26 | 2022-02-13 | Charlotte (149) | 63 | 78 | Middle Tennessee (106) | Final | W | 15 |
| 27 | 2022-02-17 | Middle Tennessee (164) | 71 | 65 | Florida International (214) | Final | W | 6 |
| 28 | 2022-02-19 | Middle Tennessee (106) | 87 | 79 | Florida Atlantic (163) | Final | W | 8 |
| 29 | 2022-02-21 | UTEP (162) | 59 | 77 | Middle Tennessee (105) | Final | W | 18 |
| 30 | 2022-02-24 | Marshall (242) | 65 | 74 | Middle Tennessee (105) | Final | W | 9 |
| 31 | 2022-02-26 | Western Kentucky (122) | 52 | 69 | Middle Tennessee (105) | Final | W | 17 |
| 32 | 2022-03-02 | Middle Tennessee (90) | 56 | 60 | Charlotte (149) | Final | L | -4 |
| 33 | 2022-03-05 | Middle Tennessee (90) | 64 | 68 | Old Dominion (207) | Final | L | -4 |
| 34 | 2022-03-10 | UTEP (152) | 59 | 66 | Middle Tennessee (104) | Final | W | 7 |
| 35 | 2022-03-11 | UAB (60) | 102 | 98 | Middle Tennessee (104) | Final | L | -4 |
| 36 | 2022-03-19 | Middle Tennessee (106) | 64 | 58 | California Baptist (214) | Final | W | 6 |
| 37 | 2022-03-21 | Middle Tennessee (106) | 76 | 46 | Boston University (210) | Final | W | 30 |
| 38 | 2022-03-22 | Middle Tennessee (106) | 85 | 69 | Abilene Christian (118) | Final | W | 16 |
| 39 | 2022-03-23 | Middle Tennessee (106) | 90 | 96 | UNC-Wilmington (131) | Final (2OT) | L | -6 |