Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Pittsburg State | 59 | 78 | Kansas State (185) | Final | W | 19 |
| 2 | 2021-11-10 | Florida A&M (309) | 57 | 67 | Kansas State (185) | Final | W | 10 |
| 3 | 2021-11-17 | Nebraska-Omaha (272) | 64 | 79 | Kansas State (96) | Final | W | 15 |
| 4 | 2021-11-22 | Arkansas (16) | 72 | 64 | Kansas State (96) | Final | L | -8 |
| 5 | 2021-11-23 | Illinois (95) | 72 | 64 | Kansas State (119) | Final | L | -8 |
| 6 | 2021-11-28 | North Dakota (310) | 42 | 84 | Kansas State (145) | Final | W | 42 |
| 7 | 2021-12-01 | Albany (330) | 43 | 71 | Kansas State (96) | Final | W | 28 |
| 8 | 2021-12-05 | Kansas State (145) | 65 | 59 | Wichita State (41) | Final | W | 6 |
| 9 | 2021-12-08 | Marquette (41) | 64 | 63 | Kansas State (89) | Final | L | -1 |
| 10 | 2021-12-12 | Green Bay (206) | 64 | 82 | Kansas State (96) | Final | W | 18 |
| 11 | 2021-12-19 | Kansas State (96) | 67 | 58 | Nebraska (13) | Final | W | 9 |
| 12 | 2021-12-21 | McNeese State (300) | 59 | 74 | Kansas State (89) | Final | W | 15 |
| 13 | 2021-12-29 | North Florida (345) | 0 | 0 | Kansas State (96) | Cancelled | - | - |
| 14 | 2021-12-29 | Morgan State | 0 | 0 | Kansas State | Cancelled | - | - |
| 15 | 2022-01-01 | Kansas State (96) | 69 | 71 | Oklahoma (47) | Final | L | -2 |
| 16 | 2022-01-04 | Texas (41) | 70 | 57 | Kansas State (96) | Final | L | -13 |
| 17 | 2022-01-08 | Kansas State (96) | 68 | 71 | West Virginia (50) | Final | L | -3 |
| 18 | 2022-01-12 | TCU (39) | 60 | 57 | Kansas State (108) | Final | L | -3 |
| 19 | 2022-01-15 | Texas Tech (20) | 51 | 62 | Kansas State (96) | Final | W | 11 |
| 20 | 2022-01-18 | Kansas State (96) | 66 | 65 | Texas (41) | Final | W | 1 |
| 21 | 2022-01-22 | Kansas (19) | 78 | 75 | Kansas State (96) | Final | L | -3 |
| 22 | 2022-01-25 | Kansas State (73) | 49 | 74 | Baylor (3) | Final | L | -25 |
| 23 | 2022-01-29 | Kansas State (96) | 56 | 67 | Ole Miss (79) | Final | L | -11 |
| 24 | 2022-02-02 | Oklahoma State (65) | 68 | 71 | Kansas State (86) | Final | W | 3 |
| 25 | 2022-02-05 | Kansas State (96) | 75 | 63 | TCU (32) | Final | W | 12 |
| 26 | 2022-02-09 | Baylor (58) | 75 | 60 | Kansas State (96) | Final | L | -15 |
| 27 | 2022-02-12 | Kansas State (96) | 75 | 69 | Iowa State (7) | Final/OT | W | 6 |
| 28 | 2022-02-14 | West Virginia (50) | 73 | 78 | Kansas State (96) | Final | W | 5 |
| 29 | 2022-02-19 | Kansas State (65) | 79 | 82 | Oklahoma State (66) | Final | L | -3 |
| 30 | 2022-02-22 | Kansas State (67) | 83 | 102 | Kansas (4) | Final | L | -19 |
| 31 | 2022-02-26 | Iowa State (32) | 74 | 73 | Kansas State (67) | Final | L | -1 |
| 32 | 2022-02-28 | Kansas State (70) | 68 | 73 | Texas Tech (12) | Final | L | -5 |
| 33 | 2022-03-05 | Oklahoma (55) | 78 | 71 | Kansas State (70) | Final | L | -7 |
| 34 | 2022-03-09 | West Virginia (70) | 73 | 67 | Kansas State (78) | Final | L | -6 |