Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Abilene Christian (73) | 56 | 70 | Utah (87) | Final | L | -14 |
| 2 | 2021-11-12 | Abilene Christian (245) | 80 | 81 | Texas A&M (39) | Final/2OT | L | -1 |
| 3 | 2021-11-16 | Abilene Christian (263) | 80 | 71 | Texas-Arlington (300) | Final (OT) | W | 9 |
| 4 | 2021-11-27 | McMurry | 54 | 89 | Abilene Christian (186) | Final | W | 35 |
| 5 | 2021-11-29 | Schreiner | 47 | 88 | Abilene Christian (195) | Final | W | 41 |
| 6 | 2021-12-01 | Dallas | 65 | 108 | Abilene Christian (245) | Final | W | 43 |
| 7 | 2021-12-04 | Incarnate Word (280) | 65 | 98 | Abilene Christian (245) | Final | W | 33 |
| 8 | 2021-12-11 | Drexel (215) | 56 | 73 | Abilene Christian (245) | Final | W | 17 |
| 9 | 2021-12-15 | Cal State-Bakersfield (333) | 59 | 69 | Abilene Christian (245) | Final | W | 10 |
| 10 | 2021-12-19 | Howard Payne | 41 | 112 | Abilene Christian (245) | Final | W | 71 |
| 11 | 2021-12-22 | Longwood (269) | 58 | 74 | Abilene Christian (245) | Final | W | 16 |
| 12 | 2021-12-30 | Abilene Christian (245) | 80 | 76 | Utah Valley (91) | Final | W | 4 |
| 13 | 2022-01-01 | Abilene Christian (245) | 64 | 50 | Utah Tech (186) | Final | W | 14 |
| 14 | 2022-01-01 | Abilene Christian (96) | 64 | 50 | Dixie State (237) | Final | W | 14 |
| 15 | 2022-01-06 | Stephen F. Austin (88) | 64 | 58 | Abilene Christian (245) | Final | L | -6 |
| 16 | 2022-01-08 | Sam Houston State (120) | 65 | 63 | Abilene Christian (245) | Final | L | -2 |
| 17 | 2022-01-13 | Abilene Christian (245) | 68 | 95 | Grand Canyon (74) | Final | L | -27 |
| 18 | 2022-01-15 | Abilene Christian (245) | 63 | 77 | New Mexico State (207) | Final | L | -14 |
| 19 | 2022-01-20 | Seattle (118) | 72 | 62 | Abilene Christian (245) | Final | L | -10 |
| 20 | 2022-01-22 | California Baptist (97) | 68 | 77 | Abilene Christian (245) | Final | W | 9 |
| 21 | 2022-01-26 | Abilene Christian (139) | 87 | 85 | UTRGV (296) | Final | W | 2 |
| 22 | 2022-01-29 | Abilene Christian (245) | 85 | 82 | Lamar (279) | Final | W | 3 |
| 23 | 2022-02-02 | Chicago State (334) | 73 | 77 | Abilene Christian (137) | Final | W | 4 |
| 24 | 2022-02-05 | UTRGV (161) | 66 | 83 | Abilene Christian (245) | Final | W | 17 |
| 25 | 2022-02-12 | Abilene Christian (245) | 77 | 63 | Tarleton State (234) | Final | W | 14 |
| 26 | 2022-02-17 | Abilene Christian (245) | 71 | 75 | Sam Houston State (120) | Final/OT | L | -4 |
| 27 | 2022-02-24 | Lamar (355) | 42 | 77 | Abilene Christian (135) | Final | W | 35 |
| 28 | 2022-02-26 | Abilene Christian (135) | 71 | 73 | Stephen F. Austin (128) | Final | L | -2 |
| 29 | 2022-03-03 | Dixie State (254) | 64 | 80 | Abilene Christian (142) | Final | W | 16 |
| 30 | 2022-03-05 | Tarleton State (224) | 56 | 61 | Abilene Christian (142) | Final | W | 5 |
| 31 | 2022-03-09 | Utah Valley (119) | 74 | 82 | Abilene Christian (129) | Final | W | 8 |
| 32 | 2022-03-10 | Abilene Christian (129) | 76 | 62 | Stephen F. Austin (109) | Final | W | 14 |
| 33 | 2022-03-11 | Abilene Christian (129) | 78 | 76 | Seattle (112) | Final | W | 2 |
| 34 | 2022-03-12 | Abilene Christian (129) | 52 | 66 | New Mexico State (76) | Final | L | -14 |
| 35 | 2022-03-20 | Abilene Christian (118) | 82 | 70 | Troy (166) | Final | W | 12 |
| 36 | 2022-03-21 | Ohio (109) | 86 | 91 | Abilene Christian (118) | Final | W | 5 |
| 37 | 2022-03-22 | Middle Tennessee (106) | 85 | 69 | Abilene Christian (118) | Final | L | -16 |