Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | St. Francis (NY) (229) | 58 | 81 | Wisconsin (30) | Final | L | -23 |
| 2 | 2021-11-13 | St. Thomas | 91 | 73 | St. Francis (NY) (229) | Final | L | -18 |
| 3 | 2021-11-18 | St. Francis (NY) (328) | 59 | 74 | Penn State (76) | Final | L | -15 |
| 4 | 2021-11-23 | St. Francis (NY) (344) | 70 | 76 | St. John's (79) | Final | L | -6 |
| 5 | 2021-11-26 | McNeese State (285) | 71 | 59 | St. Francis (NY) (344) | Final | L | -12 |
| 6 | 2021-11-27 | St. Francis (NY) (344) | 67 | 73 | North Carolina A&T (330) | Final | L | -6 |
| 7 | 2021-12-01 | St. Francis (NY) | 46 | 68 | Fordham (183) | Final | L | -22 |
| 8 | 2021-12-05 | Hartford (334) | 68 | 55 | St. Francis (NY) (352) | Final | L | -13 |
| 9 | 2021-12-08 | St. Francis (NY) (356) | 71 | 60 | Saint Peter's (238) | Final | W | 11 |
| 10 | 2021-12-11 | St. Francis (NY) | 75 | 61 | Delaware State (361) | Final | W | 14 |
| 11 | 2021-12-14 | Medgar Evers | 51 | 113 | St. Francis (NY) | Final | W | 62 |
| 12 | 2021-12-19 | Longwood (269) | 0 | 0 | St. Francis (NY) | Cancelled | - | - |
| 13 | 2021-12-23 | St. Francis (NY) | 0 | 0 | UMass-Lowell (319) | Cancelled | - | - |
| 14 | 2021-12-29 | St. Francis (NY) | 64 | 74 | Merrimack (134) | Final | L | -10 |
| 15 | 2021-12-31 | Central Connecticut State (258) | 67 | 55 | St. Francis (NY) | Final | L | -12 |
| 16 | 2022-01-06 | St. Francis (PA) (321) | 53 | 70 | St. Francis (NY) (345) | Final | W | 17 |
| 17 | 2022-01-08 | Mount St Mary's (257) | 69 | 61 | St. Francis (NY) | Final | L | -8 |
| 18 | 2022-01-15 | St. Francis (NY) | 76 | 81 | Wagner (316) | Final | L | -5 |
| 19 | 2022-01-17 | Long Island (273) | 80 | 65 | St. Francis (NY) (330) | Final | L | -15 |
| 20 | 2022-01-21 | St. Francis (NY) (330) | 80 | 78 | Fairleigh Dickinson (346) | Final | W | 2 |
| 21 | 2022-01-23 | St. Francis (NY) (334) | 68 | 85 | Bryant (206) | Final | L | -17 |
| 22 | 2022-01-27 | St. Francis (NY) | 71 | 66 | Sacred Heart (270) | Final | W | 5 |
| 23 | 2022-01-30 | Wagner (70) | 72 | 69 | St. Francis (NY) (333) | Final | L | -3 |
| 24 | 2022-02-03 | Fairleigh Dickinson (343) | 64 | 81 | St. Francis (NY) | Final | W | 17 |
| 25 | 2022-02-05 | Sacred Heart (270) | 66 | 62 | St. Francis (NY) | Final/OT | L | -4 |
| 26 | 2022-02-10 | St. Francis (NY) | 69 | 74 | Long Island (175) | Final | L | -5 |
| 27 | 2022-02-12 | St. Francis (NY) | 67 | 50 | Central Connecticut State (258) | Final | W | 17 |
| 28 | 2022-02-17 | St. Francis (NY) | 64 | 55 | Mount St Mary's (257) | Final | W | 9 |
| 29 | 2022-02-19 | St. Francis (NY) (324) | 80 | 72 | St. Francis (PA) (323) | Final | W | 8 |
| 30 | 2022-02-24 | Bryant (204) | 86 | 69 | St. Francis (NY) (315) | Final | L | -17 |
| 31 | 2022-02-26 | Merrimack (279) | 72 | 52 | St. Francis (NY) (315) | Final | L | -20 |
| 32 | 2022-03-02 | St. Francis (NY) (319) | 48 | 78 | Mount St Mary's (292) | Final | L | -30 |