Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-06 | VU of Lynchburg | 56 | 83 | Delaware State (342) | Final | W | 27 |
| 2 | 2021-11-09 | Cairn | 41 | 80 | Delaware State (342) | Final | W | 39 |
| 3 | 2021-11-12 | Salisbury | 91 | 78 | Delaware State (361) | Final | L | -13 |
| 4 | 2021-11-14 | Delaware State (361) | 53 | 63 | Rider (356) | Final | L | -10 |
| 5 | 2021-11-16 | Regent | 30 | 84 | Delaware State (358) | Final | W | 54 |
| 6 | 2021-11-20 | UNC-Wilmington (90) | 67 | 63 | Delaware State (361) | Final | L | -4 |
| 7 | 2021-11-27 | Delaware State (355) | 65 | 99 | Long Island (327) | Final | L | -34 |
| 8 | 2021-12-02 | Delaware (141) | 59 | 48 | Delaware State (357) | Final | L | -11 |
| 9 | 2021-12-04 | Delaware State (361) | 58 | 78 | Longwood (269) | Final | L | -20 |
| 10 | 2021-12-06 | Delaware State (357) | 60 | 96 | Liberty (131) | Final | L | -36 |
| 11 | 2021-12-11 | St. Francis (NY) | 75 | 61 | Delaware State (361) | Final | L | -14 |
| 12 | 2021-12-18 | North Carolina Central (341) | 86 | 53 | Delaware State (361) | Final | L | -33 |
| 13 | 2021-12-20 | Delaware State (361) | 51 | 93 | Wagner (316) | Final | L | -42 |
| 14 | 2021-12-22 | Delaware State (361) | 48 | 85 | Temple (169) | Final | L | -37 |
| 15 | 2021-12-29 | Delaware State (361) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 16 | 2022-01-08 | Howard (211) | 0 | 0 | Delaware State (361) | Postponed | - | - |
| 17 | 2022-01-12 | Delaware State (358) | 51 | 80 | Norfolk State (187) | Final | L | -29 |
| 18 | 2022-01-15 | Maryland-Eastern Shore (353) | 0 | 0 | Delaware State (361) | Postponed | - | - |
| 19 | 2022-01-22 | North Carolina Central (341) | 73 | 49 | Delaware State (361) | Final | L | -24 |
| 20 | 2022-01-24 | South Carolina State (355) | 64 | 62 | Delaware State (361) | Final | L | -2 |
| 21 | 2022-01-29 | Delaware State (361) | 0 | 0 | Morgan State (337) | Postponed | - | - |
| 22 | 2022-01-30 | Delaware State (357) | 70 | 82 | Morgan State (323) | Final | L | -12 |
| 23 | 2022-02-02 | Coppin State (307) | 59 | 57 | Delaware State (357) | Final | L | -2 |
| 24 | 2022-02-07 | Howard (211) | 69 | 64 | Delaware State (361) | Final | L | -5 |
| 25 | 2022-02-09 | Maryland-Eastern Shore (353) | 58 | 50 | Delaware State (361) | Final | L | -8 |
| 26 | 2022-02-12 | Delaware State (361) | 72 | 85 | Howard (211) | Final | L | -13 |
| 27 | 2022-02-14 | Norfolk State (322) | 69 | 66 | Delaware State (361) | Final | L | -3 |
| 28 | 2022-02-19 | Delaware State (356) | 79 | 84 | North Carolina Central (260) | Final | L | -5 |
| 29 | 2022-02-21 | Delaware State (358) | 74 | 79 | South Carolina State (296) | Final | L | -5 |
| 30 | 2022-02-26 | Morgan State (323) | 76 | 69 | Delaware State (358) | Final | L | -7 |
| 31 | 2022-02-28 | Delaware State (358) | 67 | 80 | Coppin State (317) | Final | L | -13 |
| 32 | 2022-03-03 | Delaware State (358) | 59 | 63 | Maryland-Eastern Shore (285) | Final | L | -4 |
| 33 | 2022-03-09 | Delaware State (358) | 66 | 74 | Norfolk State (153) | Final | L | -8 |