Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Old Dominion (121) | 0 | 0 | American (186) | Cancelled | - | - |
| 2 | 2021-11-06 | Gannon | 0 | 0 | Old Dominion (121) | Cancelled | - | - |
| 3 | 2021-11-10 | Virginia Wesleyan | 60 | 80 | Old Dominion (121) | Final | W | 20 |
| 4 | 2021-11-13 | Old Dominion (121) | 53 | 58 | James Madison (148) | Final | L | -5 |
| 5 | 2021-11-15 | Manhattan (81) | 58 | 79 | Old Dominion (240) | Final | W | 21 |
| 6 | 2021-11-18 | Indiana State (187) | 77 | 36 | Old Dominion (240) | Final | L | -41 |
| 7 | 2021-11-19 | East Carolina (252) | 73 | 60 | Old Dominion (254) | Final | L | -13 |
| 8 | 2021-11-21 | Penn (202) | 71 | 63 | Old Dominion (263) | Final | L | -8 |
| 9 | 2021-11-26 | Longwood (269) | 61 | 62 | Old Dominion (254) | Final | W | 1 |
| 10 | 2021-11-30 | Old Dominion (249) | 62 | 63 | East Carolina (123) | Final | L | -1 |
| 11 | 2021-12-04 | Old Dominion (254) | 60 | 50 | George Mason (86) | Final | W | 10 |
| 12 | 2021-12-07 | Old Dominion (254) | 74 | 59 | William & Mary (141) | Final | W | 15 |
| 13 | 2021-12-11 | Virginia Commonwealth (38) | 75 | 66 | Old Dominion (254) | Final | L | -9 |
| 14 | 2021-12-19 | Old Dominion (254) | 61 | 67 | Richmond (166) | Final | L | -6 |
| 15 | 2021-12-22 | Charleston (123) | 82 | 80 | Old Dominion (254) | Final | L | -2 |
| 16 | 2021-12-30 | Old Dominion (254) | 82 | 77 | Florida International (214) | Final | W | 5 |
| 17 | 2022-01-01 | Old Dominion (254) | 0 | 0 | Florida Atlantic (128) | Postponed | - | - |
| 18 | 2022-01-13 | UTSA (344) | 51 | 83 | Old Dominion (254) | Final | W | 32 |
| 19 | 2022-01-15 | UTEP (274) | 78 | 70 | Old Dominion (254) | Final/OT | L | -8 |
| 20 | 2022-01-20 | Old Dominion (254) | 69 | 77 | Rice (228) | Final | L | -8 |
| 21 | 2022-01-22 | Old Dominion (254) | 56 | 69 | North Texas (125) | Final | L | -13 |
| 22 | 2022-01-26 | Old Dominion (231) | 67 | 71 | Charlotte (131) | Final | L | -4 |
| 23 | 2022-01-29 | Charlotte (173) | 52 | 68 | Old Dominion (254) | Final | W | 16 |
| 24 | 2022-02-03 | Marshall (155) | 64 | 79 | Old Dominion (254) | Final | W | 15 |
| 25 | 2022-02-05 | Western Kentucky (154) | 77 | 60 | Old Dominion (254) | Final | L | -17 |
| 26 | 2022-02-08 | Old Dominion (212) | 62 | 81 | Florida Atlantic (168) | Final | L | -19 |
| 27 | 2022-02-10 | Old Dominion (254) | 48 | 63 | Middle Tennessee (164) | Final | L | -15 |
| 28 | 2022-02-13 | UAB (64) | 72 | 81 | Old Dominion (216) | Final | W | 9 |
| 29 | 2022-02-17 | Old Dominion (254) | 63 | 67 | Marshall (155) | Final | L | -4 |
| 30 | 2022-02-19 | Old Dominion (216) | 64 | 73 | Western Kentucky (130) | Final | L | -9 |
| 31 | 2022-02-24 | Florida Atlantic (168) | 51 | 70 | Old Dominion (229) | Final | W | 19 |
| 32 | 2022-02-26 | Florida International (203) | 63 | 83 | Old Dominion (229) | Final | W | 20 |
| 33 | 2022-03-02 | Old Dominion (207) | 54 | 67 | Louisiana Tech (108) | Final | L | -13 |
| 34 | 2022-03-05 | Middle Tennessee (90) | 64 | 68 | Old Dominion (207) | Final | W | 4 |
| 35 | 2022-03-09 | Old Dominion (202) | 64 | 74 | UTEP (152) | Final | L | -10 |