Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Maryland-Eastern Shore | 67 | 69 | Saint Joseph's (232) | Final | L | -2 |
| 2 | 2021-11-10 | Maryland-Eastern Shore | 49 | 72 | Temple (166) | Final | L | -23 |
| 3 | 2021-11-13 | Bryn Athyn | 42 | 91 | Maryland-Eastern Shore | Final | W | 49 |
| 4 | 2021-11-17 | Hood | 0 | 0 | Maryland-Eastern Shore (353) | Cancelled | - | - |
| 5 | 2021-11-19 | Maryland-Eastern Shore (353) | 75 | 73 | Fordham (183) | Final/2OT | W | 2 |
| 6 | 2021-11-24 | Maryland-Eastern Shore (353) | 55 | 66 | Campbell (191) | Final | L | -11 |
| 7 | 2021-11-27 | Maryland-Eastern Shore (230) | 61 | 73 | Liberty (236) | Final | L | -12 |
| 8 | 2021-11-30 | Maryland-Eastern Shore (264) | 63 | 72 | Connecticut (20) | Final | L | -9 |
| 9 | 2021-12-04 | Maryland-Eastern Shore (353) | 81 | 75 | Lehigh (276) | Final | W | 6 |
| 10 | 2021-12-08 | Summit | 58 | 102 | Maryland-Eastern Shore (241) | Final | W | 44 |
| 11 | 2021-12-11 | St. Mary's (MD) | 43 | 79 | Maryland-Eastern Shore (353) | Final | W | 36 |
| 12 | 2021-12-20 | Maryland-Eastern Shore (353) | 54 | 70 | Charlotte (173) | Final | L | -16 |
| 13 | 2021-12-22 | Maryland-Eastern Shore (353) | 0 | 0 | George Washington (104) | Cancelled | - | - |
| 14 | 2021-12-28 | Maryland-Eastern Shore (353) | 0 | 0 | Columbia (193) | Cancelled | - | - |
| 15 | 2021-12-30 | Longwood (269) | 0 | 0 | Maryland-Eastern Shore (353) | Cancelled | - | - |
| 16 | 2021-12-31 | Longwood (201) | 0 | 0 | Maryland-Eastern Shore (253) | Cancelled | - | - |
| 17 | 2022-01-08 | Norfolk State (322) | 0 | 0 | Maryland-Eastern Shore (353) | Postponed | - | - |
| 18 | 2022-01-15 | Maryland-Eastern Shore (353) | 0 | 0 | Delaware State (361) | Postponed | - | - |
| 19 | 2022-01-17 | Norfolk State (172) | 72 | 58 | Maryland-Eastern Shore (245) | Final | L | -14 |
| 20 | 2022-01-22 | South Carolina State (355) | 69 | 60 | Maryland-Eastern Shore (353) | Final | L | -9 |
| 21 | 2022-01-24 | North Carolina Central (341) | 75 | 63 | Maryland-Eastern Shore (353) | Final | L | -12 |
| 22 | 2022-01-29 | Maryland-Eastern Shore (353) | 64 | 61 | Coppin State (360) | Final | W | 3 |
| 23 | 2022-01-31 | Morgan State (323) | 72 | 79 | Maryland-Eastern Shore (282) | Final | W | 7 |
| 24 | 2022-02-05 | Maryland-Eastern Shore (353) | 64 | 72 | Howard (211) | Final | L | -8 |
| 25 | 2022-02-09 | Maryland-Eastern Shore (353) | 58 | 50 | Delaware State (361) | Final | W | 8 |
| 26 | 2022-02-12 | Maryland-Eastern Shore (353) | 63 | 70 | Norfolk State (322) | Final | L | -7 |
| 27 | 2022-02-14 | Howard (211) | 77 | 71 | Maryland-Eastern Shore (353) | Final | L | -6 |
| 28 | 2022-02-19 | Maryland-Eastern Shore (288) | 63 | 70 | South Carolina State (287) | Final | L | -7 |
| 29 | 2022-02-21 | Maryland-Eastern Shore (302) | 79 | 66 | North Carolina Central (250) | Final | W | 13 |
| 30 | 2022-02-26 | Coppin State (322) | 50 | 70 | Maryland-Eastern Shore (302) | Final | W | 20 |
| 31 | 2022-02-28 | Maryland-Eastern Shore (285) | 48 | 82 | Morgan State (313) | Final | L | -34 |
| 32 | 2022-03-03 | Delaware State (358) | 59 | 63 | Maryland-Eastern Shore (285) | Final | W | 4 |
| 33 | 2022-03-10 | Maryland-Eastern Shore (295) | 56 | 68 | North Carolina Central (270) | Final | L | -12 |
| 34 | 2022-03-16 | Maryland-Eastern Shore (353) | 42 | 66 | Coastal Carolina (188) | Final | L | -24 |