Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UMBC (136) | 60 | 77 | Massachusetts (129) | Final | L | -17 |
| 2 | 2021-11-15 | Penn State - York | 47 | 85 | UMBC (309) | Final | W | 38 |
| 3 | 2021-11-19 | UMBC (198) | 91 | 75 | Western Carolina (223) | Final | W | 16 |
| 4 | 2021-11-20 | UMBC (198) | 55 | 82 | Longwood (269) | Final | L | -27 |
| 5 | 2021-11-23 | American (241) | 67 | 98 | UMBC (238) | Final | W | 31 |
| 6 | 2021-11-27 | UMBC (238) | 87 | 77 | Pittsburgh (170) | Final | W | 10 |
| 7 | 2021-12-01 | Columbia (193) | 60 | 98 | UMBC (198) | Final | W | 38 |
| 8 | 2021-12-05 | UMBC (174) | 60 | 70 | Delaware (141) | Final | L | -10 |
| 9 | 2021-12-08 | UMBC (179) | 71 | 100 | Georgetown (220) | Final | L | -29 |
| 10 | 2021-12-13 | UMBC (198) | 77 | 89 | Princeton (271) | Final | L | -12 |
| 11 | 2021-12-16 | UNC-Greensboro (265) | 62 | 51 | UMBC (198) | Final | L | -11 |
| 12 | 2021-12-22 | UMBC (198) | 0 | 0 | Mount St Mary's (257) | Cancelled | - | - |
| 13 | 2021-12-29 | Radford (255) | 0 | 0 | UMBC (198) | Cancelled | - | - |
| 14 | 2022-01-02 | UMBC (198) | 0 | 0 | New Hampshire (346) | Postponed | - | - |
| 15 | 2022-01-06 | UMBC (198) | 0 | 0 | Stony Brook (213) | Postponed | - | - |
| 16 | 2022-01-08 | UMass-Lowell (319) | 66 | 64 | UMBC (198) | Final | L | -2 |
| 17 | 2022-01-12 | UMBC (252) | 76 | 56 | NJIT (229) | Final | W | 20 |
| 18 | 2022-01-15 | Vermont (225) | 86 | 69 | UMBC (198) | Final | L | -17 |
| 19 | 2022-01-17 | UMBC (242) | 51 | 65 | Stony Brook (176) | Final | L | -14 |
| 20 | 2022-01-19 | Albany (330) | 66 | 54 | UMBC (198) | Final | L | -12 |
| 21 | 2022-01-22 | UMBC (198) | 88 | 46 | Maine (350) | Final | W | 42 |
| 22 | 2022-01-26 | NJIT (291) | 69 | 73 | UMBC (257) | Final | W | 4 |
| 23 | 2022-01-29 | UMBC (198) | 70 | 68 | Binghamton (359) | Final | W | 2 |
| 24 | 2022-02-02 | UMBC (241) | 59 | 53 | Albany (265) | Final | W | 6 |
| 25 | 2022-02-05 | New Hampshire (346) | 77 | 88 | UMBC (198) | Final | W | 11 |
| 26 | 2022-02-09 | Hartford | 64 | 68 | UMBC (198) | Final | W | 4 |
| 27 | 2022-02-12 | UMBC (198) | 71 | 88 | UMass-Lowell (319) | Final | L | -17 |
| 28 | 2022-02-14 | UMBC (198) | 62 | 68 | New Hampshire (346) | Final | L | -6 |
| 29 | 2022-02-16 | Stony Brook (193) | 84 | 95 | UMBC (240) | Final | W | 11 |
| 30 | 2022-02-19 | UMBC (240) | 59 | 86 | Vermont (73) | Final | L | -27 |
| 31 | 2022-02-23 | UMBC (237) | 92 | 85 | Hartford (300) | Final | W | 7 |
| 32 | 2022-02-26 | Maine (351) | 79 | 93 | UMBC (237) | Final | W | 14 |
| 33 | 2022-03-01 | Binghamton (286) | 68 | 78 | UMBC (227) | Final | W | 10 |
| 34 | 2022-03-06 | UMass-Lowell (260) | 85 | 93 | UMBC (220) | Final | W | 8 |
| 35 | 2022-03-09 | Hartford (290) | 60 | 80 | UMBC (220) | Final | W | 20 |
| 36 | 2022-03-12 | UMBC (220) | 43 | 82 | Vermont (79) | Final | L | -39 |