Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Mid-Atlantic | 51 | 101 | Hampton (312) | Final | W | 50 |
| 2 | 2021-11-13 | Regent | 56 | 70 | Hampton (312) | Final | W | 14 |
| 3 | 2021-11-16 | Hampton (169) | 54 | 78 | Towson (203) | Final | L | -24 |
| 4 | 2021-11-19 | Hampton (260) | 60 | 77 | Wofford (221) | Final | L | -17 |
| 5 | 2021-11-20 | Hampton (260) | 66 | 86 | Georgia Southern (216) | Final | L | -20 |
| 6 | 2021-11-24 | Hampton (260) | 52 | 58 | South Florida (52) | Final | L | -6 |
| 7 | 2021-11-28 | Hampton (320) | 61 | 70 | Norfolk State (113) | Final | L | -9 |
| 8 | 2021-11-29 | Morgan State (284) | 60 | 47 | Hampton (320) | Final | L | -13 |
| 9 | 2021-12-04 | Norfolk State (322) | 57 | 58 | Hampton (260) | Final | W | 1 |
| 10 | 2021-12-09 | Hampton (312) | 54 | 53 | William & Mary (346) | Final | W | 1 |
| 11 | 2021-12-12 | Hampton (260) | 54 | 67 | Loyola-Maryland (325) | Final | L | -13 |
| 12 | 2021-12-18 | North Carolina Central (300) | 0 | 0 | Hampton (319) | Cancelled | - | - |
| 13 | 2021-12-22 | Virginia Military (357) | 0 | 0 | Hampton (260) | Cancelled | - | - |
| 14 | 2021-12-30 | Howard (211) | 0 | 0 | Hampton (260) | Cancelled | - | - |
| 15 | 2022-01-08 | Hampton (260) | 69 | 78 | Gardner-Webb (363) | Final | L | -9 |
| 16 | 2022-01-12 | Hampton (319) | 59 | 67 | North Carolina A&T (273) | Final | L | -8 |
| 17 | 2022-01-15 | Presbyterian (264) | 0 | 0 | Hampton (260) | Postponed | - | - |
| 18 | 2022-01-19 | Hampton (260) | 51 | 54 | Radford (255) | Final | L | -3 |
| 19 | 2022-01-22 | High Point (69) | 64 | 68 | Hampton (260) | Final/OT | W | 4 |
| 20 | 2022-01-24 | Longwood (269) | 73 | 48 | Hampton (260) | Final | L | -25 |
| 21 | 2022-01-24 | Longwood (162) | 73 | 49 | Hampton (332) | Final | L | -24 |
| 22 | 2022-01-26 | Hampton (332) | 60 | 75 | Campbell (219) | Final | L | -15 |
| 23 | 2022-01-29 | Hampton (260) | 78 | 74 | Charleston Southern (262) | Final | W | 4 |
| 24 | 2022-02-02 | South Carolina Upstate (248) | 85 | 78 | Hampton (336) | Final | L | -7 |
| 25 | 2022-02-05 | Winthrop (133) | 69 | 57 | Hampton (260) | Final | L | -12 |
| 26 | 2022-02-07 | Presbyterian (264) | 69 | 74 | Hampton (260) | Final | W | 5 |
| 27 | 2022-02-09 | Hampton (260) | 53 | 69 | UNC-Asheville (244) | Final | L | -16 |
| 28 | 2022-02-12 | Radford (255) | 60 | 54 | Hampton (260) | Final | L | -6 |
| 29 | 2022-02-16 | North Carolina A&T (278) | 82 | 93 | Hampton (340) | Final | W | 11 |
| 30 | 2022-02-19 | Hampton (340) | 72 | 76 | Longwood (154) | Final | L | -4 |
| 31 | 2022-02-23 | Campbell (222) | 66 | 68 | Hampton (334) | Final | W | 2 |
| 32 | 2022-02-26 | Hampton (334) | 77 | 88 | High Point (264) | Final | L | -11 |
| 33 | 2022-03-02 | Hampton (332) | 77 | 84 | High Point (256) | Final | L | -7 |