Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Old Dominion (121) | 0 | 0 | American (186) | Cancelled | - | - |
| 2 | 2021-11-09 | Marist (209) | 73 | 77 | American (186) | Final (OT) | W | 4 |
| 3 | 2021-11-12 | American (249) | 74 | 62 | William & Mary (141) | Final | W | 12 |
| 4 | 2021-11-16 | American (66) | 57 | 79 | Georgetown (275) | Final | L | -22 |
| 5 | 2021-11-19 | American (249) | 42 | 82 | Longwood (269) | Final | L | -40 |
| 6 | 2021-11-20 | Western Carolina (223) | 80 | 79 | American (249) | Final | L | -1 |
| 7 | 2021-11-20 | American (66) | 0 | 0 | Western Carolina (215) | Cancelled | - | - |
| 8 | 2021-11-23 | American (241) | 67 | 98 | UMBC (238) | Final | L | -31 |
| 9 | 2021-11-28 | American (319) | 79 | 88 | Duquesne (230) | Final | L | -9 |
| 10 | 2021-12-01 | American (249) | 57 | 80 | Stony Brook (213) | Final | L | -23 |
| 11 | 2021-12-04 | American (249) | 56 | 90 | Howard (211) | Final | L | -34 |
| 12 | 2021-12-08 | St. Francis (PA) (258) | 73 | 83 | American (340) | Final | W | 10 |
| 13 | 2021-12-11 | American (249) | 72 | 66 | Mount St Mary's (257) | Final/OT | W | 6 |
| 14 | 2021-12-21 | American (249) | 44 | 67 | George Mason (86) | Final | L | -23 |
| 15 | 2021-12-28 | Siena (160) | 0 | 0 | American (249) | Cancelled | - | - |
| 16 | 2022-01-01 | Lehigh (276) | 63 | 61 | American (249) | Final | L | -2 |
| 17 | 2022-01-04 | Lafayette (323) | 0 | 0 | American (249) | Postponed | - | - |
| 18 | 2022-01-07 | American (249) | 0 | 0 | Colgate (239) | Postponed | - | - |
| 19 | 2022-01-10 | Boston University (195) | 79 | 53 | American (320) | Final | L | -26 |
| 20 | 2022-01-13 | American (249) | 0 | 0 | Holy Cross (334) | Postponed | - | - |
| 21 | 2022-01-16 | Bucknell (339) | 55 | 63 | American (320) | Final | W | 8 |
| 22 | 2022-01-19 | American (249) | 66 | 76 | Army (339) | Final | L | -10 |
| 23 | 2022-01-22 | American (249) | 73 | 78 | Loyola-Maryland (325) | Final | L | -5 |
| 24 | 2022-01-24 | Lafayette (323) | 69 | 56 | American (249) | Final | L | -13 |
| 25 | 2022-01-26 | Holy Cross (351) | 49 | 67 | American (323) | Final | W | 18 |
| 26 | 2022-01-29 | American (249) | 45 | 47 | Navy (149) | Final | L | -2 |
| 27 | 2022-02-02 | American (326) | 62 | 71 | Lafayette (315) | Final | L | -9 |
| 28 | 2022-02-05 | Colgate (239) | 86 | 68 | American (249) | Final | L | -18 |
| 29 | 2022-02-09 | American (249) | 66 | 68 | Bucknell (336) | Final | L | -2 |
| 30 | 2022-02-12 | American (249) | 67 | 85 | Boston University (267) | Final | L | -18 |
| 31 | 2022-02-14 | American (249) | 60 | 54 | Holy Cross (334) | Final | W | 6 |
| 32 | 2022-02-16 | Navy (159) | 55 | 46 | American (339) | Final | L | -9 |
| 33 | 2022-02-19 | Army (268) | 67 | 83 | American (339) | Final | W | 16 |
| 34 | 2022-02-21 | American (327) | 49 | 63 | Colgate (182) | Final | L | -14 |
| 35 | 2022-02-23 | American (327) | 61 | 78 | Lehigh (309) | Final | L | -17 |
| 36 | 2022-02-26 | Loyola-Maryland (267) | 55 | 65 | American (327) | Final | W | 10 |
| 37 | 2022-03-01 | American (330) | 69 | 63 | Holy Cross (337) | Final | W | 6 |
| 38 | 2022-03-03 | American (330) | 64 | 71 | Navy (179) | Final | L | -7 |