Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-06 | Capital | 66 | 92 | Ohio (95) | Final | W | 26 |
| 2 | 2021-11-09 | Belmont (72) | 80 | 92 | Ohio (95) | Final | W | 12 |
| 3 | 2021-11-13 | Ohio (95) | 67 | 56 | Cleveland State (139) | Final | W | 11 |
| 4 | 2021-11-14 | Ohio (95) | 67 | 56 | Cleveland State (139) | Final | W | 11 |
| 5 | 2021-11-15 | Robert Morris (334) | 71 | 85 | Ohio (16) | Final | W | 14 |
| 6 | 2021-11-19 | Ohio (218) | 59 | 77 | Kentucky (26) | Final | L | -18 |
| 7 | 2021-11-22 | Mount St Mary's (257) | 59 | 73 | Ohio (218) | Final | W | 14 |
| 8 | 2021-11-26 | Concordia (MI) | 68 | 88 | Ohio (76) | Final | W | 20 |
| 9 | 2021-12-01 | Ohio (218) | 51 | 66 | LSU (77) | Final | L | -15 |
| 10 | 2021-12-04 | St. Francis (PA) (274) | 75 | 78 | Ohio (72) | Final | W | 3 |
| 11 | 2021-12-11 | Ohio (218) | 55 | 45 | Stetson (301) | Final | W | 10 |
| 12 | 2021-12-15 | Marshall (155) | 65 | 75 | Ohio (218) | Final | W | 10 |
| 13 | 2021-12-21 | South Carolina Upstate (293) | 70 | 85 | Ohio (218) | Final | W | 15 |
| 14 | 2021-12-28 | Eastern Michigan (277) | 0 | 0 | Ohio (218) | Postponed | - | - |
| 15 | 2022-01-01 | Ohio (218) | 59 | 47 | Western Michigan (304) | Final | W | 12 |
| 16 | 2022-01-04 | Ohio (218) | 69 | 63 | Akron (59) | Final | W | 6 |
| 17 | 2022-01-07 | Kent State (107) | 72 | 80 | Ohio (218) | Final | W | 8 |
| 18 | 2022-01-11 | Bowling Green (168) | 78 | 85 | Ohio (218) | Final | W | 7 |
| 19 | 2022-01-15 | Ohio (218) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 20 | 2022-01-18 | Ohio (218) | 86 | 63 | Miami (OH) (40) | Final | W | 23 |
| 21 | 2022-01-21 | Toledo (79) | 87 | 69 | Ohio (49) | Final | L | -18 |
| 22 | 2022-01-25 | Northern Illinois (284) | 62 | 74 | Ohio (60) | Final | W | 12 |
| 23 | 2022-01-28 | Ohio (60) | 74 | 53 | Buffalo (140) | Final | W | 21 |
| 24 | 2022-02-01 | Ball State (236) | 63 | 87 | Ohio (53) | Final | W | 24 |
| 25 | 2022-02-03 | Eastern Michigan (277) | 68 | 81 | Ohio (218) | Final | W | 13 |
| 26 | 2022-02-05 | Western Michigan (304) | 64 | 77 | Ohio (218) | Final | W | 13 |
| 27 | 2022-02-08 | Ohio (49) | 62 | 77 | Toledo (71) | Final | L | -15 |
| 28 | 2022-02-10 | Ohio (218) | 81 | 72 | Central Michigan (311) | Final | W | 9 |
| 29 | 2022-02-12 | Ohio (218) | 74 | 56 | Eastern Michigan (277) | Final | W | 18 |
| 30 | 2022-02-15 | Miami (OH) (255) | 78 | 91 | Ohio (61) | Final | W | 13 |
| 31 | 2022-02-18 | Ohio (61) | 52 | 75 | Kent State (140) | Final | L | -23 |
| 32 | 2022-02-22 | Central Michigan (312) | 50 | 76 | Ohio (77) | Final | W | 26 |
| 33 | 2022-02-25 | Akron (156) | 91 | 83 | Ohio (77) | Final | L | -8 |
| 34 | 2022-03-01 | Ohio (85) | 77 | 80 | Bowling Green (270) | Final | L | -3 |
| 35 | 2022-03-04 | Ohio (85) | 57 | 58 | Northern Illinois (297) | Final | L | -1 |
| 36 | 2022-03-10 | Ball State (252) | 67 | 77 | Ohio (106) | Final | W | 10 |
| 37 | 2022-03-11 | Ohio (106) | 61 | 67 | Kent State (115) | Final | L | -6 |
| 38 | 2022-03-19 | Ohio (109) | 65 | 64 | Rice (202) | Final | W | 1 |
| 39 | 2022-03-21 | Ohio (109) | 86 | 91 | Abilene Christian (118) | Final | L | -5 |