Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-11 | Regent | 24 | 85 | Liberty (86) | Final | W | 61 |
| 2 | 2021-11-15 | Liberty (127) | 58 | 74 | LSU (15) | Final | L | -16 |
| 3 | 2021-11-19 | Liberty (93) | 50 | 54 | Iona (220) | Final | L | -4 |
| 4 | 2021-11-20 | Manhattan (307) | 76 | 60 | Liberty (93) | Final | L | -16 |
| 5 | 2021-11-23 | Bethune-Cookman (290) | 51 | 59 | Liberty (236) | Final | W | 8 |
| 6 | 2021-11-27 | Maryland-Eastern Shore (230) | 61 | 73 | Liberty (236) | Final | W | 12 |
| 7 | 2021-12-02 | Missouri (186) | 45 | 66 | Liberty (159) | Final | W | 21 |
| 8 | 2021-12-06 | Delaware State (357) | 60 | 96 | Liberty (131) | Final | W | 36 |
| 9 | 2021-12-11 | Liberty (93) | 51 | 63 | Stephen F. Austin (88) | Final | L | -12 |
| 10 | 2021-12-13 | Kentucky Christian | 0 | 0 | Liberty | Cancelled | - | - |
| 11 | 2021-12-13 | Carver Bible | 36 | 95 | Liberty (154) | Final | W | 59 |
| 12 | 2021-12-17 | Liberty (93) | 74 | 64 | East Carolina (252) | Final | W | 10 |
| 13 | 2021-12-22 | Liberty (93) | 76 | 74 | Northern Iowa (89) | Final | W | 2 |
| 14 | 2021-12-23 | Liberty (93) | 76 | 79 | Stanford (60) | Final | L | -3 |
| 15 | 2021-12-25 | Liberty (93) | 75 | 80 | BYU (23) | Final | L | -5 |
| 16 | 2021-12-31 | Boyce | 60 | 91 | Liberty (93) | Final | W | 31 |
| 17 | 2022-01-04 | Liberty (93) | 75 | 59 | Stetson (301) | Final | W | 16 |
| 18 | 2022-01-08 | Kennesaw State (142) | 0 | 0 | Liberty (93) | Postponed | - | - |
| 19 | 2022-01-11 | North Florida (345) | 56 | 71 | Liberty (93) | Final | W | 15 |
| 20 | 2022-01-15 | Liberty (93) | 78 | 75 | Florida Gulf Coast (241) | Final | W | 3 |
| 21 | 2022-01-18 | Jacksonville (281) | 49 | 88 | Liberty (93) | Final | W | 39 |
| 22 | 2022-01-22 | Liberty (93) | 0 | 0 | Central Arkansas (143) | Postponed | - | - |
| 23 | 2022-01-27 | North Alabama (335) | 53 | 72 | Liberty (93) | Final | W | 19 |
| 24 | 2022-01-29 | Jacksonville State (227) | 77 | 67 | Liberty (93) | Final | L | -10 |
| 25 | 2022-01-31 | Liberty (115) | 65 | 50 | Kennesaw State (249) | Final | W | 15 |
| 26 | 2022-02-03 | Liberty (93) | 66 | 53 | Bellarmine (266) | Final | W | 13 |
| 27 | 2022-02-05 | Liberty (93) | 91 | 84 | Eastern Kentucky (288) | Final | W | 7 |
| 28 | 2022-02-08 | Lipscomb (290) | 69 | 78 | Liberty (105) | Final | W | 9 |
| 29 | 2022-02-12 | Liberty (93) | 69 | 73 | Jacksonville (281) | Final | L | -4 |
| 30 | 2022-02-15 | Liberty (112) | 69 | 72 | North Florida (283) | Final | L | -3 |
| 31 | 2022-02-19 | Stetson (280) | 82 | 88 | Liberty (112) | Final | W | 6 |
| 32 | 2022-02-21 | Liberty (120) | 85 | 66 | Central Arkansas (285) | Final | W | 19 |
| 33 | 2022-02-23 | Florida Gulf Coast (188) | 82 | 72 | Liberty (120) | Final | L | -10 |
| 34 | 2022-02-26 | Kennesaw State (256) | 93 | 100 | Liberty (120) | Final | W | 7 |
| 35 | 2022-03-03 | Lipscomb (281) | 47 | 52 | Liberty (120) | Final | W | 5 |
| 36 | 2022-03-05 | Bellarmine (198) | 53 | 50 | Liberty (120) | Final | L | -3 |