Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | UTEP (184) | 0 | 0 | TCU (113) | Cancelled | - | - |
| 2 | 2021-11-11 | McNeese State (318) | 61 | 77 | TCU (113) | Final | W | 16 |
| 3 | 2021-11-15 | Southern Miss (284) | 51 | 83 | TCU (121) | Final | W | 32 |
| 4 | 2021-11-18 | Nicholls State (87) | 50 | 63 | TCU (121) | Final | W | 13 |
| 5 | 2021-11-22 | Santa Clara (42) | 85 | 66 | TCU (32) | Final | L | -19 |
| 6 | 2021-11-24 | TCU (32) | 73 | 64 | Pepperdine (283) | Final | W | 9 |
| 7 | 2021-11-29 | Austin Peay (224) | 51 | 68 | TCU (85) | Final | W | 17 |
| 8 | 2021-12-02 | Oral Roberts (258) | 63 | 71 | TCU (85) | Final | W | 8 |
| 9 | 2021-12-08 | Utah (52) | 62 | 76 | TCU (70) | Final | W | 14 |
| 10 | 2021-12-11 | TCU (32) | 68 | 64 | Texas A&M (39) | Final | W | 4 |
| 11 | 2021-12-18 | TCU (32) | 80 | 73 | Georgetown (83) | Final | W | 7 |
| 12 | 2021-12-21 | Grambling (312) | 55 | 90 | TCU (32) | Final | W | 35 |
| 13 | 2021-12-29 | Texas Southern (317) | 0 | 0 | TCU (32) | Cancelled | - | - |
| 14 | 2022-01-03 | West Virginia (50) | 0 | 0 | TCU (32) | Postponed | - | - |
| 15 | 2022-01-08 | Baylor (58) | 76 | 64 | TCU (32) | Final | L | -12 |
| 16 | 2022-01-12 | TCU (39) | 60 | 57 | Kansas State (108) | Final | W | 3 |
| 17 | 2022-01-15 | Oklahoma (47) | 58 | 59 | TCU (32) | Final/OT | W | 1 |
| 18 | 2022-01-19 | TCU (32) | 56 | 57 | Oklahoma State (57) | Final | L | -1 |
| 19 | 2022-01-22 | TCU (32) | 59 | 44 | Iowa State (7) | Final | W | 15 |
| 20 | 2022-01-25 | Texas (34) | 73 | 50 | TCU (39) | Final | L | -23 |
| 21 | 2022-01-29 | LSU (77) | 68 | 77 | TCU (32) | Final | W | 9 |
| 22 | 2022-01-31 | TCU (33) | 72 | 63 | Oklahoma (41) | Final | W | 9 |
| 23 | 2022-02-05 | Kansas State (96) | 75 | 63 | TCU (32) | Final | L | -12 |
| 24 | 2022-02-08 | Oklahoma State (66) | 73 | 77 | TCU (40) | Final | W | 4 |
| 25 | 2022-02-12 | TCU (32) | 69 | 82 | Texas Tech (20) | Final | L | -13 |
| 26 | 2022-02-15 | Iowa State (39) | 54 | 51 | TCU (36) | Final | L | -3 |
| 27 | 2022-02-19 | TCU (36) | 62 | 72 | Baylor (4) | Final | L | -10 |
| 28 | 2022-02-21 | West Virginia (57) | 67 | 77 | TCU (42) | Final | W | 10 |
| 29 | 2022-02-23 | TCU (42) | 66 | 75 | Texas (21) | Final | L | -9 |
| 30 | 2022-02-26 | Texas Tech (8) | 66 | 69 | TCU (42) | Final | W | 3 |
| 31 | 2022-03-01 | Kansas (5) | 64 | 74 | TCU (38) | Final | W | 10 |
| 32 | 2022-03-03 | TCU (38) | 68 | 72 | Kansas (5) | Final | L | -4 |
| 33 | 2022-03-05 | TCU (38) | 64 | 70 | West Virginia (66) | Final | L | -6 |
| 34 | 2022-03-10 | TCU (37) | 65 | 60 | Texas (23) | Final | W | 5 |
| 35 | 2022-03-11 | TCU (37) | 62 | 75 | Kansas (5) | Final | L | -13 |
| 36 | 2022-03-18 | TCU (35) | 69 | 42 | Seton Hall (29) | Final | W | 27 |
| 37 | 2022-03-20 | TCU (35) | 80 | 85 | Arizona (1) | Final (OT) | L | -5 |