Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Mount St Mary's (179) | 51 | 91 | Villanova (21) | Final | L | -40 |
| 2 | 2021-11-11 | Washington College | 62 | 117 | Mount St Mary's (179) | Final | W | 55 |
| 3 | 2021-11-13 | Mount St Mary's (179) | 60 | 80 | Saint Joseph's (232) | Final | L | -20 |
| 4 | 2021-11-16 | Mount St Mary's (305) | 55 | 80 | Kentucky (129) | Final | L | -25 |
| 5 | 2021-11-19 | Mount St Mary's (257) | 74 | 70 | Robert Morris (148) | Final/OT | W | 4 |
| 6 | 2021-11-22 | Mount St Mary's (257) | 59 | 73 | Ohio (218) | Final | L | -14 |
| 7 | 2021-11-27 | Navy (135) | 67 | 40 | Mount St Mary's (268) | Final | L | -27 |
| 8 | 2021-11-30 | Howard (245) | 70 | 72 | Mount St Mary's (292) | Final | W | 2 |
| 9 | 2021-12-04 | Mount St Mary's (257) | 55 | 61 | Loyola-Maryland (325) | Final | L | -6 |
| 10 | 2021-12-07 | Mount St Mary's (257) | 77 | 88 | Santa Clara (42) | Final | L | -11 |
| 11 | 2021-12-11 | American (249) | 72 | 66 | Mount St Mary's (257) | Final/OT | L | -6 |
| 12 | 2021-12-18 | Morgan State (337) | 60 | 74 | Mount St Mary's (257) | Final | W | 14 |
| 13 | 2021-12-22 | UMBC (198) | 0 | 0 | Mount St Mary's (257) | Cancelled | - | - |
| 14 | 2021-12-29 | Fairleigh Dickinson (343) | 2 | 0 | Mount St Mary's (257) | Forfeit | L | -2 |
| 15 | 2021-12-31 | Wagner (316) | 2 | 0 | Mount St Mary's (257) | Forfeit | L | -2 |
| 16 | 2022-01-06 | Mount St Mary's (257) | 57 | 74 | Long Island (175) | Final | L | -17 |
| 17 | 2022-01-08 | Mount St Mary's (257) | 69 | 61 | St. Francis (NY) | Final | W | 8 |
| 18 | 2022-01-15 | Mount St Mary's (257) | 66 | 73 | Bryant (349) | Final | L | -7 |
| 19 | 2022-01-17 | Mount St Mary's (299) | 57 | 50 | Merrimack (287) | Final | W | 7 |
| 20 | 2022-01-21 | Sacred Heart (298) | 59 | 98 | Mount St Mary's (299) | Final | W | 39 |
| 21 | 2022-01-23 | Central Connecticut State (345) | 50 | 65 | Mount St Mary's (272) | Final | W | 15 |
| 22 | 2022-01-27 | Mount St Mary's (257) | 67 | 56 | Fairleigh Dickinson (343) | Final | W | 11 |
| 23 | 2022-01-29 | St. Francis (PA) (320) | 54 | 71 | Mount St Mary's (260) | Final | W | 17 |
| 24 | 2022-02-03 | Merrimack (134) | 53 | 69 | Mount St Mary's (257) | Final | W | 16 |
| 25 | 2022-02-05 | Bryant (349) | 62 | 61 | Mount St Mary's (257) | Final | L | -1 |
| 26 | 2022-02-10 | Mount St Mary's (257) | 57 | 69 | Wagner (316) | Final | L | -12 |
| 27 | 2022-02-12 | Mount St Mary's (257) | 54 | 52 | Saint Francis (354) | Final | W | 2 |
| 28 | 2022-02-12 | Mount St Mary's (258) | 54 | 52 | St. Francis (PA) (326) | Final | W | 2 |
| 29 | 2022-02-15 | Mount St Mary's (258) | 70 | 71 | Manhattanville | Final (OT) | L | -1 |
| 30 | 2022-02-17 | St. Francis (NY) | 64 | 55 | Mount St Mary's (257) | Final | L | -9 |
| 31 | 2022-02-19 | Long Island (272) | 66 | 61 | Mount St Mary's (258) | Final | L | -5 |
| 32 | 2022-02-24 | Mount St Mary's (289) | 65 | 77 | Sacred Heart (336) | Final | L | -12 |
| 33 | 2022-02-26 | Mount St Mary's (289) | 65 | 46 | Central Connecticut State (345) | Final | W | 19 |
| 34 | 2022-03-02 | St. Francis (NY) (319) | 48 | 78 | Mount St Mary's (292) | Final | W | 30 |
| 35 | 2022-03-05 | Mount St Mary's (292) | 69 | 70 | Bryant (191) | Final | L | -1 |