Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-29 | Akron (122) | 0 | 0 | West Virginia (17) | Cancelled | - | - |
| 2 | 2021-11-09 | Oakland (250) | 53 | 60 | West Virginia (17) | Final | W | 7 |
| 3 | 2021-11-12 | Pittsburgh (108) | 59 | 74 | West Virginia (50) | Final | W | 15 |
| 4 | 2021-11-19 | Marquette (106) | 82 | 71 | West Virginia (50) | Final | L | -11 |
| 5 | 2021-11-19 | Elon (224) | 68 | 87 | West Virginia (47) | Final | W | 19 |
| 6 | 2021-11-21 | Clemson (49) | 59 | 66 | West Virginia (39) | Final | W | 7 |
| 7 | 2021-11-26 | Eastern Kentucky (288) | 77 | 80 | West Virginia (50) | Final | W | 3 |
| 8 | 2021-11-30 | Bellarmine (246) | 55 | 74 | West Virginia (36) | Final | W | 19 |
| 9 | 2021-12-04 | Radford (255) | 51 | 67 | West Virginia (50) | Final | W | 16 |
| 10 | 2021-12-08 | Connecticut (17) | 53 | 56 | West Virginia (40) | Final | W | 3 |
| 11 | 2021-12-12 | Kent State (107) | 50 | 63 | West Virginia (50) | Final | W | 13 |
| 12 | 2021-12-18 | West Virginia (50) | 65 | 59 | UAB (115) | Final | W | 6 |
| 13 | 2021-12-22 | Youngstown State (231) | 52 | 82 | West Virginia (50) | Final | W | 30 |
| 14 | 2022-01-01 | West Virginia (50) | 59 | 74 | Texas (41) | Final | L | -15 |
| 15 | 2022-01-03 | West Virginia (50) | 0 | 0 | TCU (32) | Postponed | - | - |
| 16 | 2022-01-08 | Kansas State (96) | 68 | 71 | West Virginia (50) | Final | W | 3 |
| 17 | 2022-01-11 | Oklahoma State (57) | 60 | 70 | West Virginia (50) | Final | W | 10 |
| 18 | 2022-01-15 | West Virginia (50) | 59 | 85 | Kansas (19) | Final | L | -26 |
| 19 | 2022-01-18 | Baylor (58) | 77 | 68 | West Virginia (50) | Final | L | -9 |
| 20 | 2022-01-22 | West Virginia (50) | 65 | 78 | Texas Tech (20) | Final | L | -13 |
| 21 | 2022-01-26 | Oklahoma (51) | 72 | 62 | West Virginia (33) | Final | L | -10 |
| 22 | 2022-01-29 | West Virginia (50) | 68 | 77 | Arkansas (16) | Final | L | -9 |
| 23 | 2022-01-31 | West Virginia (46) | 77 | 81 | Baylor (3) | Final | L | -4 |
| 24 | 2022-02-05 | Texas Tech (20) | 60 | 53 | West Virginia (50) | Final | L | -7 |
| 25 | 2022-02-08 | Iowa State (30) | 63 | 79 | West Virginia (47) | Final | W | 16 |
| 26 | 2022-02-12 | West Virginia (50) | 58 | 81 | Oklahoma State (57) | Final | L | -23 |
| 27 | 2022-02-14 | West Virginia (50) | 73 | 78 | Kansas State (96) | Final | L | -5 |
| 28 | 2022-02-19 | Kansas (6) | 71 | 58 | West Virginia (50) | Final | L | -13 |
| 29 | 2022-02-21 | West Virginia (57) | 67 | 77 | TCU (42) | Final | L | -10 |
| 30 | 2022-02-23 | West Virginia (57) | 81 | 84 | Iowa State (32) | Final | L | -3 |
| 31 | 2022-02-26 | Texas (21) | 82 | 81 | West Virginia (57) | Final | L | -1 |
| 32 | 2022-03-01 | West Virginia (66) | 59 | 72 | Oklahoma (55) | Final | L | -13 |
| 33 | 2022-03-05 | TCU (38) | 64 | 70 | West Virginia (66) | Final | W | 6 |
| 34 | 2022-03-09 | West Virginia (70) | 73 | 67 | Kansas State (78) | Final | W | 6 |
| 35 | 2022-03-10 | West Virginia (70) | 63 | 87 | Kansas (5) | Final | L | -24 |