Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-02 | Central Christian (KS) | 50 | 73 | Tarleton State (247) | Final | W | 23 |
| 2 | 2021-11-09 | Tarleton State (247) | 50 | 62 | Stanford (81) | Final | L | -12 |
| 3 | 2021-11-12 | Tarleton State (234) | 62 | 88 | Kansas (19) | Final | L | -26 |
| 4 | 2021-11-16 | Tarleton State (326) | 51 | 65 | Wichita State (21) | Final | L | -14 |
| 5 | 2021-11-19 | Paul Quinn | 42 | 69 | Tarleton State (234) | Final | W | 27 |
| 6 | 2021-11-22 | Tarleton State (234) | 53 | 54 | North Dakota State (117) | Final | L | -1 |
| 7 | 2021-11-24 | Tarleton State (234) | 54 | 65 | Michigan (1) | Final | L | -11 |
| 8 | 2021-11-29 | Tarleton State (307) | 55 | 64 | Gonzaga (7) | Final | L | -9 |
| 9 | 2021-12-05 | Charleston Southern (323) | 59 | 57 | Tarleton State (307) | Final | L | -2 |
| 10 | 2021-12-07 | Dallas Christian | 65 | 84 | Tarleton State (234) | Final | W | 19 |
| 11 | 2021-12-08 | Southwestern Assemblies of God | 75 | 81 | Tarleton State (326) | Final | W | 6 |
| 12 | 2021-12-14 | Tarleton State (234) | 62 | 69 | South Alabama (177) | Final | L | -7 |
| 13 | 2021-12-17 | South Alabama (177) | 52 | 65 | Tarleton State (234) | Final | W | 13 |
| 14 | 2021-12-21 | Air Force (347) | 45 | 67 | Tarleton State (234) | Final | W | 22 |
| 15 | 2021-12-21 | Air Force (203) | 81 | 67 | Tarleton State (283) | Final | L | -14 |
| 16 | 2021-12-30 | Tarleton State (234) | 83 | 69 | Utah Tech (186) | Final | W | 14 |
| 17 | 2021-12-30 | Tarleton State (249) | 83 | 69 | Dixie State (237) | Final | W | 14 |
| 18 | 2022-01-01 | Tarleton State (234) | 55 | 77 | Utah Valley (91) | Final | L | -22 |
| 19 | 2022-01-06 | Sam Houston State (120) | 64 | 75 | Tarleton State (234) | Final | W | 11 |
| 20 | 2022-01-08 | Stephen F. Austin (88) | 71 | 77 | Tarleton State (234) | Final/OT | W | 6 |
| 21 | 2022-01-13 | Tarleton State (234) | 57 | 73 | New Mexico State (207) | Final | L | -16 |
| 22 | 2022-01-15 | Tarleton State (234) | 59 | 80 | Grand Canyon (74) | Final | L | -21 |
| 23 | 2022-01-20 | California Baptist (97) | 88 | 84 | Tarleton State (234) | Final | L | -4 |
| 24 | 2022-01-22 | Seattle (118) | 76 | 68 | Tarleton State (234) | Final | L | -8 |
| 25 | 2022-01-26 | Tarleton State (235) | 62 | 57 | Lamar (353) | Final | W | 5 |
| 26 | 2022-01-29 | Tarleton State (234) | 79 | 64 | UTRGV (161) | Final | W | 15 |
| 27 | 2022-02-05 | Chicago State (351) | 54 | 57 | Tarleton State (234) | Final | W | 3 |
| 28 | 2022-02-12 | Abilene Christian (245) | 77 | 63 | Tarleton State (234) | Final | L | -14 |
| 29 | 2022-02-16 | Utah Valley (114) | 69 | 56 | Tarleton State (229) | Final | L | -13 |
| 30 | 2022-02-19 | Tarleton State (229) | 79 | 60 | Chicago State (337) | Final | W | 19 |
| 31 | 2022-02-24 | UTRGV (316) | 62 | 75 | Tarleton State (230) | Final | W | 13 |
| 32 | 2022-02-26 | Lamar (355) | 49 | 57 | Tarleton State (230) | Final | W | 8 |
| 33 | 2022-03-03 | Tarleton State (224) | 50 | 69 | Sam Houston State (175) | Final | L | -19 |
| 34 | 2022-03-05 | Tarleton State (224) | 56 | 61 | Abilene Christian (142) | Final | L | -5 |