Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Morehouse | 70 | 86 | Harvard | Final | W | 16 |
| 2 | 2021-11-13 | Harvard | 87 | 90 | Iona (134) | Final (OT) | L | -3 |
| 3 | 2021-11-17 | Harvard (181) | 60 | 53 | Albany (330) | Final | W | 7 |
| 4 | 2021-11-20 | MIT | 52 | 98 | Harvard (181) | Final | W | 46 |
| 5 | 2021-11-22 | Harvard (181) | 69 | 72 | Siena (160) | Final | L | -3 |
| 6 | 2021-11-24 | Colgate (239) | 84 | 89 | Harvard (181) | Final/OT | W | 5 |
| 7 | 2021-11-27 | Northeastern (136) | 57 | 77 | Harvard (179) | Final | W | 20 |
| 8 | 2021-12-01 | Rhode Island (145) | 64 | 57 | Harvard (181) | Final | L | -7 |
| 9 | 2021-12-04 | Harvard (181) | 77 | 87 | Massachusetts (182) | Final | L | -10 |
| 10 | 2021-12-06 | Babson | 64 | 74 | Harvard (195) | Final | W | 10 |
| 11 | 2021-12-19 | Holy Cross (334) | 54 | 62 | Harvard (181) | Final | W | 8 |
| 12 | 2021-12-21 | Howard (211) | 69 | 77 | Harvard (181) | Final | W | 8 |
| 13 | 2021-12-29 | Harvard | 0 | 0 | Kansas | Cancelled | - | - |
| 14 | 2022-01-02 | Princeton (271) | 0 | 0 | Harvard (181) | Postponed | - | - |
| 15 | 2022-01-07 | Brown (295) | 84 | 73 | Harvard (181) | Final | L | -11 |
| 16 | 2022-01-15 | Harvard (181) | 91 | 82 | Columbia (193) | Final | W | 9 |
| 17 | 2022-01-17 | Harvard (211) | 60 | 59 | Dartmouth (284) | Final | W | 1 |
| 18 | 2022-01-22 | Harvard (181) | 61 | 76 | Cornell (187) | Final | L | -15 |
| 19 | 2022-01-28 | Penn (225) | 78 | 74 | Harvard (223) | Final | L | -4 |
| 20 | 2022-02-04 | Harvard (235) | 65 | 50 | Brown (221) | Final | W | 15 |
| 21 | 2022-02-05 | Harvard (181) | 55 | 58 | Yale (81) | Final | L | -3 |
| 22 | 2022-02-09 | Yale (81) | 62 | 59 | Harvard (181) | Final | L | -3 |
| 23 | 2022-02-12 | Harvard (181) | 74 | 82 | Penn (131) | Final | L | -8 |
| 24 | 2022-02-18 | Columbia (349) | 54 | 62 | Harvard (236) | Final | W | 8 |
| 25 | 2022-02-19 | Cornell (169) | 72 | 77 | Harvard (236) | Final (OT) | W | 5 |
| 26 | 2022-02-25 | Harvard (220) | 67 | 74 | Princeton (103) | Final | L | -7 |
| 27 | 2022-02-27 | Princeton (99) | 74 | 73 | Harvard (221) | Final | L | -1 |
| 28 | 2022-03-05 | Dartmouth (265) | 76 | 54 | Harvard (221) | Final | L | -22 |