Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Concordia-St. Paul | 67 | 80 | Minnesota (64) | Final | W | 13 |
| 2 | 2021-11-09 | UMKC (272) | 56 | 71 | Minnesota (64) | Final | W | 15 |
| 3 | 2021-11-12 | Western Kentucky (154) | 69 | 73 | Minnesota (87) | Final | W | 4 |
| 4 | 2021-11-14 | Minnesota (87) | 87 | 80 | Princeton (271) | Final/2OT | W | 7 |
| 5 | 2021-11-19 | Purdue Fort Wayne (222) | 49 | 78 | Minnesota (87) | Final | W | 29 |
| 6 | 2021-11-24 | Jacksonville (281) | 44 | 55 | Minnesota (87) | Final | W | 11 |
| 7 | 2021-11-30 | Minnesota (21) | 54 | 53 | Pittsburgh (229) | Final | W | 1 |
| 8 | 2021-12-05 | Minnesota (21) | 81 | 76 | Mississippi State (40) | Final | W | 5 |
| 9 | 2021-12-08 | Michigan State (19) | 75 | 67 | Minnesota (18) | Final | L | -8 |
| 10 | 2021-12-11 | Minnesota (87) | 75 | 65 | Michigan (1) | Final | W | 10 |
| 11 | 2021-12-14 | Texas A&M-Corpus Christi (208) | 71 | 79 | Minnesota (87) | Final | W | 8 |
| 12 | 2021-12-22 | Green Bay (206) | 56 | 72 | Minnesota (87) | Final | W | 16 |
| 13 | 2021-12-29 | Alcorn State (348) | 0 | 0 | Minnesota (87) | Cancelled | - | - |
| 14 | 2022-01-04 | Illinois (9) | 76 | 53 | Minnesota (87) | Final | L | -23 |
| 15 | 2022-01-09 | Minnesota (46) | 60 | 73 | Indiana (32) | Final | L | -13 |
| 16 | 2022-01-12 | Minnesota (46) | 69 | 71 | Michigan State (7) | Final | L | -2 |
| 17 | 2022-01-16 | Iowa (25) | 81 | 71 | Minnesota (55) | Final | L | -10 |
| 18 | 2022-01-19 | Minnesota (87) | 0 | 0 | Penn State (129) | Postponed | - | - |
| 19 | 2022-01-22 | Rutgers (112) | 65 | 68 | Minnesota (87) | Final | W | 3 |
| 20 | 2022-01-27 | Ohio State (34) | 75 | 64 | Minnesota (87) | Final | L | -11 |
| 21 | 2022-01-30 | Minnesota (64) | 60 | 66 | Wisconsin (9) | Final | L | -6 |
| 22 | 2022-02-02 | Purdue (8) | 88 | 73 | Minnesota (64) | Final | L | -15 |
| 23 | 2022-02-06 | Minnesota (87) | 59 | 71 | Iowa (28) | Final | L | -12 |
| 24 | 2022-02-09 | Minnesota (87) | 65 | 78 | Nebraska (13) | Final | L | -13 |
| 25 | 2022-02-12 | Penn State (129) | 70 | 76 | Minnesota (87) | Final | W | 6 |
| 26 | 2022-02-15 | Minnesota (82) | 45 | 70 | Ohio State (27) | Final | L | -25 |
| 27 | 2022-02-17 | Minnesota (87) | 46 | 67 | Penn State (129) | Final | L | -21 |
| 28 | 2022-02-19 | Northwestern (80) | 60 | 77 | Minnesota (82) | Final | W | 17 |
| 29 | 2022-02-23 | Wisconsin (15) | 68 | 67 | Minnesota (84) | Final | L | -1 |
| 30 | 2022-02-27 | Indiana (44) | 84 | 79 | Minnesota (89) | Final | L | -5 |
| 31 | 2022-03-02 | Minnesota (89) | 73 | 84 | Maryland (82) | Final | L | -11 |
| 32 | 2022-03-06 | Minnesota (103) | 62 | 75 | Northwestern (93) | Final | L | -13 |
| 33 | 2022-03-09 | Minnesota (103) | 51 | 60 | Penn State (100) | Final | L | -9 |