Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Detroit (192) | 47 | 85 | Wyoming (145) | Final | W | 38 |
| 2 | 2021-11-14 | Arkansas-Pine Bluff (303) | 45 | 85 | Wyoming (103) | Final | W | 40 |
| 3 | 2021-11-18 | Wyoming (37) | 77 | 72 | Washington (211) | Final (OT) | W | 5 |
| 4 | 2021-11-22 | Wyoming (103) | 68 | 61 | Grand Canyon (74) | Final | W | 7 |
| 5 | 2021-11-26 | Hastings | 59 | 108 | Wyoming (103) | Final | W | 49 |
| 6 | 2021-11-29 | Wyoming (32) | 79 | 66 | Cal State-Fullerton (184) | Final | W | 13 |
| 7 | 2021-12-02 | Denver (342) | 64 | 77 | Wyoming (32) | Final | W | 13 |
| 8 | 2021-12-04 | McNeese State (271) | 58 | 79 | Wyoming (32) | Final | W | 21 |
| 9 | 2021-12-08 | Wyoming (27) | 65 | 94 | Arizona (4) | Final | L | -29 |
| 10 | 2021-12-11 | Utah Valley (91) | 62 | 74 | Wyoming (103) | Final | W | 12 |
| 11 | 2021-12-22 | Wyoming (103) | 63 | 66 | Stanford (60) | Final | L | -3 |
| 12 | 2021-12-23 | Northern Iowa (89) | 69 | 71 | Wyoming (103) | Final | W | 2 |
| 13 | 2021-12-25 | Wyoming (103) | 77 | 57 | South Florida (52) | Final | W | 20 |
| 14 | 2022-01-01 | Boise State (62) | 0 | 0 | Wyoming (103) | Postponed | - | - |
| 15 | 2022-01-04 | Wyoming (103) | 0 | 0 | Nevada (67) | Postponed | - | - |
| 16 | 2022-01-08 | Wyoming (103) | 0 | 0 | Fresno State (153) | Postponed | - | - |
| 17 | 2022-01-15 | Wyoming (103) | 71 | 69 | Utah State (25) | Final | W | 2 |
| 18 | 2022-01-17 | Wyoming (37) | 77 | 67 | Nevada (120) | Final | W | 10 |
| 19 | 2022-01-19 | San Jose State (229) | 69 | 84 | Wyoming (103) | Final | W | 15 |
| 20 | 2022-01-22 | New Mexico (49) | 91 | 93 | Wyoming (103) | Final | W | 2 |
| 21 | 2022-01-25 | Wyoming (29) | 62 | 65 | Boise State (52) | Final | L | -3 |
| 22 | 2022-01-28 | Wyoming (29) | 63 | 61 | Air Force (185) | Final | W | 2 |
| 23 | 2022-01-31 | Colorado State (28) | 78 | 84 | Wyoming (38) | Final (OT) | W | 6 |
| 24 | 2022-02-03 | Boise State (62) | 65 | 72 | Wyoming (103) | Final | W | 7 |
| 25 | 2022-02-06 | Wyoming (103) | 61 | 59 | Fresno State (153) | Final | W | 2 |
| 26 | 2022-02-08 | Utah State (67) | 76 | 78 | Wyoming (25) | Final (OT) | W | 2 |
| 27 | 2022-02-12 | Wyoming (103) | 74 | 52 | San Jose State (229) | Final | W | 22 |
| 28 | 2022-02-15 | Wyoming (21) | 66 | 75 | New Mexico (165) | Final | L | -9 |
| 29 | 2022-02-19 | Air Force (208) | 67 | 75 | Wyoming (21) | Final | W | 8 |
| 30 | 2022-02-23 | Wyoming (31) | 55 | 61 | Colorado State (25) | Final | L | -6 |
| 31 | 2022-02-26 | Nevada (121) | 61 | 74 | Wyoming (31) | Final | W | 13 |
| 32 | 2022-02-28 | San Diego State (36) | 73 | 66 | Wyoming (34) | Final | L | -7 |
| 33 | 2022-03-02 | Wyoming (34) | 57 | 64 | UNLV (84) | Final | L | -7 |
| 34 | 2022-03-05 | Fresno State (87) | 64 | 68 | Wyoming (34) | Final | W | 4 |
| 35 | 2022-03-10 | UNLV (82) | 56 | 59 | Wyoming (42) | Final | W | 3 |
| 36 | 2022-03-11 | Wyoming (42) | 61 | 68 | Boise State (31) | Final | L | -7 |
| 37 | 2022-03-15 | Indiana (49) | 66 | 58 | Wyoming (41) | Final | L | -8 |