Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-31 | Davis & Elkins | 72 | 113 | Marshall (88) | Final | W | 41 |
| 2 | 2021-11-07 | Pikeville | 59 | 86 | Marshall (25) | Final | W | 27 |
| 3 | 2021-11-12 | Wright State (124) | 88 | 96 | Marshall (155) | Final | W | 8 |
| 4 | 2021-11-15 | Milligan | 58 | 80 | Marshall (107) | Final | W | 22 |
| 5 | 2021-11-18 | Campbell (168) | 67 | 65 | Marshall (107) | Final | L | -2 |
| 6 | 2021-11-21 | Jackson State (329) | 66 | 80 | Marshall (167) | Final | W | 14 |
| 7 | 2021-11-23 | Louisiana (178) | 79 | 93 | Marshall (167) | Final | W | 14 |
| 8 | 2021-11-27 | Marshall (167) | 79 | 90 | Indiana (17) | Final | L | -11 |
| 9 | 2021-12-01 | Marshall (155) | 86 | 88 | Akron (59) | Final | L | -2 |
| 10 | 2021-12-04 | Duquesne (121) | 71 | 72 | Marshall (155) | Final | W | 1 |
| 11 | 2021-12-08 | Bluefield | 57 | 100 | Marshall (170) | Final | W | 43 |
| 12 | 2021-12-11 | Marshall (155) | 80 | 69 | Eastern Kentucky (288) | Final | W | 11 |
| 13 | 2021-12-15 | Marshall (155) | 65 | 75 | Ohio (218) | Final | L | -10 |
| 14 | 2021-12-18 | Northern Iowa (89) | 75 | 60 | Marshall (155) | Final | L | -15 |
| 15 | 2021-12-21 | Marshall (155) | 63 | 95 | Toledo (135) | Final | L | -32 |
| 16 | 2021-12-30 | Marshall (155) | 56 | 79 | Louisiana Tech (185) | Final | L | -23 |
| 17 | 2022-01-01 | Marshall (155) | 0 | 0 | Southern Miss (201) | Postponed | - | - |
| 18 | 2022-01-08 | Florida Atlantic (128) | 90 | 77 | Marshall (155) | Final | L | -13 |
| 19 | 2022-01-13 | North Texas (125) | 69 | 65 | Marshall (155) | Final | L | -4 |
| 20 | 2022-01-15 | Rice (228) | 87 | 77 | Marshall (155) | Final | L | -10 |
| 21 | 2022-01-20 | Marshall (155) | 66 | 70 | Florida International (214) | Final | L | -4 |
| 22 | 2022-01-22 | Marshall (155) | 60 | 71 | Florida Atlantic (128) | Final | L | -11 |
| 23 | 2022-01-27 | Middle Tennessee (164) | 81 | 79 | Marshall (155) | Final | L | -2 |
| 24 | 2022-01-29 | UAB (115) | 81 | 84 | Marshall (155) | Final | W | 3 |
| 25 | 2022-02-03 | Marshall (155) | 64 | 79 | Old Dominion (254) | Final | L | -15 |
| 26 | 2022-02-05 | Marshall (155) | 64 | 88 | Charlotte (173) | Final | L | -24 |
| 27 | 2022-02-10 | Florida International (214) | 72 | 71 | Marshall (155) | Final | L | -1 |
| 28 | 2022-02-13 | Marshall (246) | 88 | 79 | UTEP (179) | Final | W | 9 |
| 29 | 2022-02-17 | Old Dominion (254) | 63 | 67 | Marshall (155) | Final | W | 4 |
| 30 | 2022-02-19 | Charlotte (149) | 99 | 84 | Marshall (246) | Final | L | -15 |
| 31 | 2022-02-21 | Marshall (242) | 74 | 60 | Southern Miss (325) | Final | W | 14 |
| 32 | 2022-02-24 | Marshall (242) | 65 | 74 | Middle Tennessee (105) | Final | L | -9 |
| 33 | 2022-03-02 | Western Kentucky (124) | 86 | 72 | Marshall (241) | Final | L | -14 |
| 34 | 2022-03-05 | Marshall (241) | 69 | 78 | Western Kentucky (124) | Final | L | -9 |
| 35 | 2022-03-08 | Marshall (248) | 74 | 62 | Florida International (229) | Final | W | 12 |
| 36 | 2022-03-09 | Marshall (248) | 67 | 77 | Louisiana Tech (108) | Final | L | -10 |