Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Lake Erie | 64 | 75 | Northern Kentucky (205) | Final | W | 11 |
| 2 | 2021-11-09 | Wheeling Jesuit | 54 | 82 | Northern Kentucky (205) | Final | W | 28 |
| 3 | 2021-11-12 | UNC-Greensboro (265) | 70 | 69 | Northern Kentucky (195) | Final/OT | L | -1 |
| 4 | 2021-11-18 | Eastern Michigan (135) | 73 | 74 | Northern Kentucky (244) | Final | W | 1 |
| 5 | 2021-11-22 | Western Illinois (362) | 69 | 67 | Northern Kentucky (195) | Final | L | -2 |
| 6 | 2021-11-26 | Northern Kentucky (195) | 68 | 77 | DePaul (95) | Final | L | -9 |
| 7 | 2021-12-02 | Northern Kentucky (218) | 58 | 72 | Cleveland State (202) | Final | L | -14 |
| 8 | 2021-12-04 | Northern Kentucky (195) | 57 | 71 | Purdue Fort Wayne (222) | Final | L | -14 |
| 9 | 2021-12-08 | Canisius (278) | 62 | 75 | Northern Kentucky (281) | Final | W | 13 |
| 10 | 2021-12-12 | Alice Lloyd | 55 | 91 | Northern Kentucky (195) | Final | W | 36 |
| 11 | 2021-12-18 | Northern Kentucky (195) | 68 | 81 | Eastern Kentucky (288) | Final/OT | L | -13 |
| 12 | 2021-12-22 | Northern Kentucky (195) | 61 | 79 | Indiana (46) | Final | L | -18 |
| 13 | 2021-12-30 | Green Bay (206) | 74 | 79 | Northern Kentucky (195) | Final | W | 5 |
| 14 | 2022-01-01 | Milwaukee (261) | 61 | 55 | Northern Kentucky (195) | Final | L | -6 |
| 15 | 2022-01-06 | IU-Indy (338) | 0 | 0 | Northern Kentucky (195) | Canceled | - | - |
| 16 | 2022-01-08 | Illinois-Chicago (139) | 0 | 0 | Northern Kentucky (195) | Canceled | - | - |
| 17 | 2022-01-13 | Northern Kentucky (195) | 68 | 67 | Youngstown State (231) | Final | W | 1 |
| 18 | 2022-01-15 | Northern Kentucky (195) | 64 | 74 | Robert Morris (148) | Final | L | -10 |
| 19 | 2022-01-20 | Northern Kentucky (195) | 74 | 70 | Illinois-Chicago (139) | Final/OT | W | 4 |
| 20 | 2022-01-22 | Northern Kentucky (195) | 60 | 41 | IU-Indy (338) | Final | W | 19 |
| 21 | 2022-01-22 | Northern Kentucky (297) | 60 | 41 | IUPUI (358) | Final | W | 19 |
| 22 | 2022-01-25 | Wright State (224) | 63 | 73 | Northern Kentucky (286) | Final | W | 10 |
| 23 | 2022-01-28 | Purdue Fort Wayne (230) | 49 | 59 | Northern Kentucky (286) | Final | W | 10 |
| 24 | 2022-01-30 | Cleveland State (135) | 72 | 78 | Northern Kentucky (246) | Final | W | 6 |
| 25 | 2022-02-03 | Oakland (172) | 0 | 0 | Northern Kentucky (195) | Postponed | - | - |
| 26 | 2022-02-04 | Oakland (81) | 78 | 87 | Northern Kentucky (246) | Final (OT) | W | 9 |
| 27 | 2022-02-05 | Detroit (212) | 74 | 68 | Northern Kentucky (195) | Final | L | -6 |
| 28 | 2022-02-09 | Northern Kentucky (195) | 75 | 39 | Milwaukee (261) | Final | W | 36 |
| 29 | 2022-02-11 | Northern Kentucky (195) | 71 | 62 | Green Bay (206) | Final | W | 9 |
| 30 | 2022-02-13 | Northern Kentucky (215) | 75 | 71 | Wright State (221) | Final | W | 4 |
| 31 | 2022-02-18 | Northern Kentucky (215) | 52 | 60 | Detroit (267) | Final | L | -8 |
| 32 | 2022-02-20 | Northern Kentucky (223) | 71 | 66 | Oakland (143) | Final | W | 5 |
| 33 | 2022-02-24 | Robert Morris (338) | 64 | 78 | Northern Kentucky (223) | Final | W | 14 |
| 34 | 2022-02-26 | Youngstown State (227) | 61 | 75 | Northern Kentucky (223) | Final | W | 14 |
| 35 | 2022-03-03 | Detroit (237) | 59 | 77 | Northern Kentucky (206) | Final | W | 18 |
| 36 | 2022-03-07 | Northern Kentucky (201) | 57 | 43 | Purdue Fort Wayne (199) | Final | W | 14 |
| 37 | 2022-03-08 | Wright State (203) | 72 | 71 | Northern Kentucky (201) | Final | L | -1 |