Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Goshen | 66 | 94 | Eastern Michigan (305) | Final | W | 28 |
| 2 | 2021-11-09 | Eastern Michigan (305) | 62 | 68 | Indiana (61) | Final | L | -6 |
| 3 | 2021-11-12 | Illinois State (94) | 98 | 103 | Eastern Michigan (277) | Final/2OT | W | 5 |
| 4 | 2021-11-18 | Eastern Michigan (135) | 73 | 74 | Northern Kentucky (244) | Final | L | -1 |
| 5 | 2021-11-20 | Eastern Michigan (277) | 59 | 83 | Michigan State (10) | Final | L | -24 |
| 6 | 2021-11-24 | Western Illinois (362) | 68 | 72 | Eastern Michigan (277) | Final | W | 4 |
| 7 | 2021-11-28 | Eastern Michigan (199) | 63 | 101 | DePaul (22) | Final | L | -38 |
| 8 | 2021-12-02 | Eastern Michigan (199) | 74 | 83 | UC-San Diego (157) | Final | L | -9 |
| 9 | 2021-12-05 | Northwood | 57 | 79 | Eastern Michigan (199) | Final | W | 22 |
| 10 | 2021-12-08 | Niagara (197) | 58 | 60 | Eastern Michigan (244) | Final | W | 2 |
| 11 | 2021-12-11 | Florida International (214) | 88 | 92 | Eastern Michigan (277) | Final/4OT | W | 4 |
| 12 | 2021-12-20 | Eastern Michigan (277) | 55 | 67 | Valparaiso (156) | Final | L | -12 |
| 13 | 2021-12-28 | Eastern Michigan (277) | 0 | 0 | Ohio (218) | Postponed | - | - |
| 14 | 2022-01-01 | Buffalo (219) | 0 | 0 | Eastern Michigan (277) | Postponed | - | - |
| 15 | 2022-01-04 | Eastern Michigan (277) | 85 | 79 | Western Michigan (304) | Final | W | 6 |
| 16 | 2022-01-08 | Ball State (298) | 78 | 72 | Eastern Michigan (277) | Final | L | -6 |
| 17 | 2022-01-11 | Central Michigan (311) | 68 | 99 | Eastern Michigan (277) | Final | W | 31 |
| 18 | 2022-01-15 | Eastern Michigan (277) | 70 | 77 | Northern Illinois (326) | Final | L | -7 |
| 19 | 2022-01-18 | Kent State (107) | 56 | 47 | Eastern Michigan (277) | Final | L | -9 |
| 20 | 2022-01-22 | Eastern Michigan (277) | 44 | 46 | Akron (59) | Final | L | -2 |
| 21 | 2022-01-25 | Eastern Michigan (266) | 71 | 85 | Bowling Green (203) | Final | L | -14 |
| 22 | 2022-01-29 | Miami (OH) (40) | 75 | 85 | Eastern Michigan (277) | Final | W | 10 |
| 23 | 2022-02-01 | Toledo (58) | 86 | 66 | Eastern Michigan (261) | Final | L | -20 |
| 24 | 2022-02-03 | Eastern Michigan (277) | 68 | 81 | Ohio (218) | Final | L | -13 |
| 25 | 2022-02-05 | Eastern Michigan (277) | 71 | 90 | Kent State (107) | Final | L | -19 |
| 26 | 2022-02-08 | Eastern Michigan (272) | 64 | 102 | Buffalo (152) | Final | L | -38 |
| 27 | 2022-02-12 | Ohio (218) | 74 | 56 | Eastern Michigan (277) | Final | L | -18 |
| 28 | 2022-02-15 | Eastern Michigan (277) | 75 | 70 | Central Michigan (308) | Final | W | 5 |
| 29 | 2022-02-17 | Buffalo (219) | 83 | 69 | Eastern Michigan (277) | Final | L | -14 |
| 30 | 2022-02-19 | Akron (128) | 67 | 48 | Eastern Michigan (277) | Final | L | -19 |
| 31 | 2022-02-22 | Northern Illinois (291) | 72 | 74 | Eastern Michigan (280) | Final | W | 2 |
| 32 | 2022-02-26 | Eastern Michigan (280) | 64 | 75 | Ball State (249) | Final | L | -11 |
| 33 | 2022-03-01 | Western Michigan (335) | 71 | 60 | Eastern Michigan (283) | Final | L | -11 |
| 34 | 2022-03-04 | Eastern Michigan (283) | 63 | 76 | Miami (OH) (274) | Final | L | -13 |