Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Hofstra (163) | 75 | 83 | Houston (5) | Final (OT) | L | -8 |
| 2 | 2021-11-13 | Hofstra (163) | 73 | 63 | Duquesne (143) | Final | W | 10 |
| 3 | 2021-11-16 | Hofstra (117) | 74 | 82 | Iona (67) | Final | L | -8 |
| 4 | 2021-11-19 | Hofstra (98) | 67 | 69 | Maryland (114) | Final | L | -2 |
| 5 | 2021-11-22 | Hofstra (98) | 68 | 81 | Richmond (166) | Final | L | -13 |
| 6 | 2021-11-24 | Molloy | 49 | 87 | Hofstra (98) | Final | W | 38 |
| 7 | 2021-11-27 | Detroit (316) | 84 | 98 | Hofstra (194) | Final | W | 14 |
| 8 | 2021-12-01 | Princeton (271) | 77 | 81 | Hofstra (98) | Final | W | 4 |
| 9 | 2021-12-04 | Bucknell (336) | 69 | 88 | Hofstra (98) | Final | W | 19 |
| 10 | 2021-12-08 | Hofstra (140) | 62 | 79 | Stony Brook (227) | Final | L | -17 |
| 11 | 2021-12-12 | John Jay | 51 | 102 | Hofstra (98) | Final | W | 51 |
| 12 | 2021-12-18 | Hofstra (98) | 89 | 81 | Arkansas (16) | Final | W | 8 |
| 13 | 2021-12-22 | Hofstra (98) | 77 | 71 | Monmouth (176) | Final | W | 6 |
| 14 | 2021-12-29 | Hofstra (98) | 62 | 63 | William & Mary (141) | Final | L | -1 |
| 15 | 2021-12-31 | Hofstra (98) | 0 | 0 | Elon (232) | Postponed | - | - |
| 16 | 2022-01-03 | UNC-Wilmington (90) | 0 | 0 | Hofstra (98) | Postponed | - | - |
| 17 | 2022-01-05 | Charleston (123) | 0 | 0 | Hofstra (98) | Postponed | - | - |
| 18 | 2022-01-09 | Hofstra (119) | 87 | 80 | James Madison (100) | Final | W | 7 |
| 19 | 2022-01-11 | Hofstra (98) | 66 | 78 | Towson (152) | Final | L | -12 |
| 20 | 2022-01-15 | Delaware (287) | 77 | 82 | Hofstra (98) | Final | W | 5 |
| 21 | 2022-01-17 | Drexel (166) | 68 | 71 | Hofstra (119) | Final | W | 3 |
| 22 | 2022-01-22 | Hofstra (98) | 72 | 50 | Northeastern (300) | Final | W | 22 |
| 23 | 2022-01-27 | Hofstra (98) | 76 | 73 | Charleston (123) | Final | W | 3 |
| 24 | 2022-01-29 | Hofstra (98) | 72 | 78 | UNC-Wilmington (90) | Final | L | -6 |
| 25 | 2022-02-03 | Towson (152) | 78 | 68 | Hofstra (98) | Final | L | -10 |
| 26 | 2022-02-05 | James Madison (202) | 78 | 85 | Hofstra (98) | Final/OT | W | 7 |
| 27 | 2022-02-07 | UNC-Wilmington (90) | 71 | 73 | Hofstra (98) | Final | W | 2 |
| 28 | 2022-02-10 | Hofstra (98) | 83 | 73 | Drexel (215) | Final | W | 10 |
| 29 | 2022-02-12 | Hofstra (98) | 80 | 66 | Delaware (287) | Final | W | 14 |
| 30 | 2022-02-19 | Northeastern (266) | 73 | 76 | Hofstra (105) | Final | W | 3 |
| 31 | 2022-02-24 | Elon (273) | 81 | 55 | Hofstra (100) | Final | L | -26 |
| 32 | 2022-02-26 | William & Mary (332) | 67 | 83 | Hofstra (100) | Final | W | 16 |
| 33 | 2022-02-28 | Charleston (150) | 84 | 89 | Hofstra (109) | Final | W | 5 |
| 34 | 2022-03-06 | Charleston (148) | 92 | 76 | Hofstra (111) | Final | L | -16 |