Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Auburn-Montgomery | 70 | 101 | UAB (78) | Final | W | 31 |
| 2 | 2021-11-09 | UNC-Asheville (255) | 77 | 102 | UAB (78) | Final | W | 25 |
| 3 | 2021-11-12 | Morehead State (233) | 71 | 85 | UAB (115) | Final | W | 14 |
| 4 | 2021-11-14 | Rhodes College | 61 | 98 | UAB (115) | Final | W | 37 |
| 5 | 2021-11-18 | UAB (77) | 63 | 66 | South Carolina (120) | Final | L | -3 |
| 6 | 2021-11-21 | Alabama A&M (302) | 41 | 86 | UAB (84) | Final | W | 45 |
| 7 | 2021-11-25 | UAB (115) | 86 | 73 | New Mexico (49) | Final | W | 13 |
| 8 | 2021-11-26 | San Francisco (122) | 63 | 61 | UAB (115) | Final | L | -2 |
| 9 | 2021-12-01 | East Tennessee State (140) | 56 | 70 | UAB (115) | Final | W | 14 |
| 10 | 2021-12-04 | UAB (115) | 77 | 72 | Saint Louis (31) | Final | W | 5 |
| 11 | 2021-12-12 | Millsaps | 29 | 103 | UAB (115) | Final | W | 74 |
| 12 | 2021-12-14 | Grambling (312) | 61 | 79 | UAB (115) | Final | W | 18 |
| 13 | 2021-12-18 | West Virginia (50) | 65 | 59 | UAB (115) | Final | L | -6 |
| 14 | 2021-12-22 | Mississippi Valley State (365) | 58 | 100 | UAB (115) | Final | W | 42 |
| 15 | 2021-12-30 | UTEP (274) | 62 | 75 | UAB (115) | Final | W | 13 |
| 16 | 2022-01-01 | UTSA (344) | 59 | 87 | UAB (115) | Final | W | 28 |
| 17 | 2022-01-06 | UAB (115) | 69 | 63 | North Texas (125) | Final | W | 6 |
| 18 | 2022-01-08 | UAB (115) | 80 | 85 | Rice (228) | Final | L | -5 |
| 19 | 2022-01-13 | Florida International (214) | 56 | 84 | UAB (115) | Final | W | 28 |
| 20 | 2022-01-15 | Florida Atlantic (128) | 65 | 76 | UAB (115) | Final | W | 11 |
| 21 | 2022-01-22 | UAB (115) | 83 | 76 | Louisiana Tech (185) | Final | W | 7 |
| 22 | 2022-01-27 | UAB (115) | 68 | 65 | Western Kentucky (154) | Final | W | 3 |
| 23 | 2022-01-29 | UAB (115) | 81 | 84 | Marshall (155) | Final | L | -3 |
| 24 | 2022-02-05 | Middle Tennessee (164) | 75 | 97 | UAB (115) | Final | W | 22 |
| 25 | 2022-02-10 | Southern Miss (201) | 63 | 84 | UAB (115) | Final | W | 21 |
| 26 | 2022-02-13 | UAB (64) | 72 | 81 | Old Dominion (216) | Final | L | -9 |
| 27 | 2022-02-17 | Rice (228) | 68 | 92 | UAB (115) | Final | W | 24 |
| 28 | 2022-02-19 | North Texas (46) | 58 | 57 | UAB (64) | Final | L | -1 |
| 29 | 2022-02-24 | UAB (64) | 68 | 56 | UTSA (324) | Final | W | 12 |
| 30 | 2022-02-26 | UAB (64) | 69 | 66 | UTEP (162) | Final | W | 3 |
| 31 | 2022-03-02 | UAB (63) | 81 | 68 | Southern Miss (336) | Final | W | 13 |
| 32 | 2022-03-05 | Louisiana Tech (108) | 74 | 87 | UAB (63) | Final | W | 13 |
| 33 | 2022-03-10 | Florida Atlantic (159) | 66 | 80 | UAB (60) | Final | W | 14 |
| 34 | 2022-03-11 | UAB (60) | 102 | 98 | Middle Tennessee (104) | Final | W | 4 |
| 35 | 2022-03-12 | Louisiana Tech (108) | 73 | 82 | UAB (60) | Final | W | 9 |
| 36 | 2022-03-18 | UAB (53) | 68 | 82 | Houston (9) | Final | L | -14 |