Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | St. Edward's | 71 | 85 | Rice (190) | Final | W | 14 |
| 2 | 2021-11-09 | Pepperdine (104) | 63 | 82 | Rice (190) | Final | W | 19 |
| 3 | 2021-11-12 | Rice (228) | 46 | 79 | Houston (5) | Final | L | -33 |
| 4 | 2021-11-16 | Southern (181) | 63 | 81 | Rice (155) | Final | W | 18 |
| 5 | 2021-11-19 | Rice (228) | 83 | 78 | New Orleans (236) | Final | W | 5 |
| 6 | 2021-11-22 | Evansville (302) | 104 | 109 | Rice (228) | Final/3OT | W | 5 |
| 7 | 2021-11-23 | Oakland (98) | 76 | 73 | Rice (106) | Final | L | -3 |
| 8 | 2021-11-24 | Fordham (183) | 84 | 74 | Rice (228) | Final | L | -10 |
| 9 | 2021-11-30 | Texas State (129) | 80 | 69 | Rice (151) | Final | L | -11 |
| 10 | 2021-12-04 | Jarvis Christian | 62 | 100 | Rice (228) | Final | W | 38 |
| 11 | 2021-12-11 | Rice (228) | 88 | 73 | Houston Christian (305) | Final | W | 15 |
| 12 | 2021-12-11 | Rice (177) | 88 | 73 | Houston Baptist (322) | Final | W | 15 |
| 13 | 2021-12-16 | Incarnate Word (280) | 55 | 85 | Rice (228) | Final | W | 30 |
| 14 | 2021-12-19 | St. Thomas (TX) | 0 | 0 | Rice (228) | Cancelled | - | - |
| 15 | 2022-01-01 | Rice (228) | 43 | 75 | North Texas (125) | Final | L | -32 |
| 16 | 2022-01-06 | Middle Tennessee (164) | 61 | 65 | Rice (228) | Final | W | 4 |
| 17 | 2022-01-08 | UAB (115) | 80 | 85 | Rice (228) | Final | W | 5 |
| 18 | 2022-01-13 | Rice (228) | 66 | 80 | Western Kentucky (154) | Final | L | -14 |
| 19 | 2022-01-15 | Rice (228) | 87 | 77 | Marshall (155) | Final | W | 10 |
| 20 | 2022-01-20 | Old Dominion (254) | 69 | 77 | Rice (228) | Final | W | 8 |
| 21 | 2022-01-22 | Charlotte (173) | 67 | 64 | Rice (228) | Final | L | -3 |
| 22 | 2022-01-27 | Rice (228) | 63 | 80 | Louisiana Tech (185) | Final | L | -17 |
| 23 | 2022-01-29 | Rice (228) | 76 | 62 | Southern Miss (201) | Final | W | 14 |
| 24 | 2022-02-03 | UTSA (344) | 78 | 91 | Rice (228) | Final | W | 13 |
| 25 | 2022-02-05 | UTEP (274) | 72 | 70 | Rice (228) | Final | L | -2 |
| 26 | 2022-02-12 | North Texas (125) | 67 | 44 | Rice (228) | Final | L | -23 |
| 27 | 2022-02-17 | Rice (228) | 68 | 92 | UAB (115) | Final | L | -24 |
| 28 | 2022-02-19 | Rice (168) | 78 | 80 | Florida International (209) | Final | L | -2 |
| 29 | 2022-02-24 | Louisiana Tech (107) | 83 | 79 | Rice (184) | Final | L | -4 |
| 30 | 2022-02-26 | Southern Miss (325) | 72 | 77 | Rice (184) | Final | W | 5 |
| 31 | 2022-03-03 | Rice (192) | 67 | 70 | UTEP (176) | Final | L | -3 |
| 32 | 2022-03-05 | Rice (192) | 71 | 82 | UTSA (329) | Final | L | -11 |
| 33 | 2022-03-09 | Rice (209) | 73 | 61 | Charlotte (147) | Final | W | 12 |
| 34 | 2022-03-10 | Rice (209) | 50 | 68 | North Texas (49) | Final | L | -18 |
| 35 | 2022-03-19 | Ohio (109) | 65 | 64 | Rice (202) | Final | L | -1 |