Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Lake Erie | 53 | 86 | Wright State (90) | Final | W | 33 |
| 2 | 2021-11-12 | Wright State (124) | 88 | 96 | Marshall (155) | Final | L | -8 |
| 3 | 2021-11-16 | Wright State (251) | 52 | 96 | Purdue (27) | Final | L | -44 |
| 4 | 2021-11-22 | Wright State (124) | 63 | 74 | George Washington (104) | Final | L | -11 |
| 5 | 2021-11-23 | Wright State (282) | 76 | 78 | James Madison (11) | Final | L | -2 |
| 6 | 2021-11-24 | Long Beach State (278) | 85 | 76 | Wright State (124) | Final | L | -9 |
| 7 | 2021-12-02 | Wright State (344) | 86 | 73 | Purdue Fort Wayne (235) | Final | W | 13 |
| 8 | 2021-12-04 | Wright State (124) | 75 | 85 | Cleveland State (308) | Final | L | -10 |
| 9 | 2021-12-15 | Akron (59) | 66 | 48 | Wright State (124) | Final | L | -18 |
| 10 | 2021-12-18 | Tennessee Tech (310) | 63 | 72 | Wright State (124) | Final | W | 9 |
| 11 | 2021-12-21 | Wright State (124) | 84 | 70 | North Carolina State (44) | Final | W | 14 |
| 12 | 2021-12-30 | Milwaukee (261) | 75 | 80 | Wright State (124) | Final | W | 5 |
| 13 | 2022-01-01 | Green Bay (206) | 69 | 72 | Wright State (124) | Final | W | 3 |
| 14 | 2022-01-06 | Illinois-Chicago (139) | 72 | 90 | Wright State (124) | Final | W | 18 |
| 15 | 2022-01-08 | IUPUI (357) | 58 | 72 | Wright State (257) | Final | W | 14 |
| 16 | 2022-01-13 | Wright State (124) | 75 | 73 | Robert Morris (148) | Final | W | 2 |
| 17 | 2022-01-15 | Wright State (124) | 87 | 90 | Youngstown State (231) | Final | L | -3 |
| 18 | 2022-01-20 | Wright State (124) | 73 | 45 | IU-Indy (338) | Final | W | 28 |
| 19 | 2022-01-20 | Wright State (246) | 73 | 45 | IUPUI (358) | Final | W | 28 |
| 20 | 2022-01-22 | Wright State (124) | 97 | 81 | Illinois-Chicago (139) | Final | W | 16 |
| 21 | 2022-01-25 | Wright State (224) | 63 | 73 | Northern Kentucky (286) | Final | L | -10 |
| 22 | 2022-01-28 | Cleveland State (128) | 71 | 67 | Wright State (224) | Final | L | -4 |
| 23 | 2022-01-30 | Purdue Fort Wayne (254) | 63 | 75 | Wright State (232) | Final | W | 12 |
| 24 | 2022-02-03 | Detroit (212) | 0 | 0 | Wright State (124) | Postponed | - | - |
| 25 | 2022-02-04 | Detroit (267) | 59 | 90 | Wright State (232) | Final | W | 31 |
| 26 | 2022-02-05 | Oakland (172) | 64 | 75 | Wright State (124) | Final | W | 11 |
| 27 | 2022-02-09 | Wright State (124) | 79 | 62 | Green Bay (206) | Final | W | 17 |
| 28 | 2022-02-11 | Wright State (124) | 57 | 60 | Milwaukee (261) | Final | L | -3 |
| 29 | 2022-02-13 | Northern Kentucky (215) | 75 | 71 | Wright State (221) | Final | L | -4 |
| 30 | 2022-02-18 | Wright State (221) | 78 | 74 | Oakland (117) | Final | W | 4 |
| 31 | 2022-02-20 | Wright State (224) | 75 | 80 | Detroit (244) | Final | L | -5 |
| 32 | 2022-02-24 | Youngstown State (227) | 71 | 84 | Wright State (224) | Final | W | 13 |
| 33 | 2022-02-26 | Robert Morris (338) | 61 | 71 | Wright State (224) | Final | W | 10 |
| 34 | 2022-03-03 | Oakland (148) | 63 | 75 | Wright State (211) | Final | W | 12 |
| 35 | 2022-03-07 | Wright State (203) | 82 | 67 | Cleveland State (180) | Final | W | 15 |
| 36 | 2022-03-08 | Wright State (203) | 72 | 71 | Northern Kentucky (201) | Final | W | 1 |
| 37 | 2022-03-16 | Bryant (349) | 82 | 93 | Wright State (124) | Final | W | 11 |
| 38 | 2022-03-18 | Wright State (195) | 70 | 87 | Arizona (1) | Final | L | -17 |