Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | UC-San Diego (242) | 44 | 57 | Loyola Marymount (84) | Final | L | -13 |
| 2 | 2021-11-09 | UC-San Diego (242) | 80 | 67 | California (165) | Final | W | 13 |
| 3 | 2021-11-13 | George Washington (260) | 55 | 75 | UC-San Diego (242) | Final | W | 20 |
| 4 | 2021-11-16 | San Diego Christian | 60 | 97 | UC-San Diego (49) | Final | W | 37 |
| 5 | 2021-11-20 | UC-San Diego (126) | 71 | 56 | Sacramento State (313) | Final | W | 15 |
| 6 | 2021-11-24 | UC-San Diego (126) | 61 | 71 | Montana (230) | Final | L | -10 |
| 7 | 2021-11-25 | UC-San Diego (126) | 55 | 56 | Southern Miss (201) | Final | L | -1 |
| 8 | 2021-11-26 | UC-San Diego (126) | 0 | 0 | UNC-Wilmington (90) | Cancelled | - | - |
| 9 | 2021-12-02 | Eastern Michigan (199) | 74 | 83 | UC-San Diego (157) | Final | W | 9 |
| 10 | 2021-12-12 | UC-San Diego (126) | 51 | 73 | Seattle (118) | Final | L | -22 |
| 11 | 2021-12-15 | UC-San Diego (126) | 56 | 64 | Denver (253) | Final | L | -8 |
| 12 | 2021-12-18 | Cal Tech | 52 | 93 | UC-San Diego (126) | Final | W | 41 |
| 13 | 2021-12-22 | UC-San Diego (126) | 57 | 78 | San Diego State (48) | Final | L | -21 |
| 14 | 2021-12-30 | UC-Santa Barbara (171) | 83 | 85 | UC-San Diego (126) | Final/OT | W | 2 |
| 15 | 2022-01-01 | Cal State-Northridge (180) | 64 | 72 | UC-San Diego (126) | Final | W | 8 |
| 16 | 2022-01-06 | UC-San Diego (126) | 51 | 59 | UC-Riverside (292) | Final | L | -8 |
| 17 | 2022-01-08 | UC-San Diego (126) | 71 | 78 | UC-Davis (170) | Final | L | -7 |
| 18 | 2022-01-11 | UC-San Diego (126) | 0 | 0 | UC-Irvine (119) | Canceled | - | - |
| 19 | 2022-01-15 | UC-San Diego (126) | 56 | 79 | Hawaii (109) | Final | L | -23 |
| 20 | 2022-01-16 | UC-San Diego (258) | 56 | 79 | Hawaii (179) | Final | L | -23 |
| 21 | 2022-01-20 | Long Beach State (278) | 87 | 69 | UC-San Diego (126) | Final | L | -18 |
| 22 | 2022-01-22 | UC-San Diego (126) | 80 | 83 | Cal State-Fullerton (194) | Final | L | -3 |
| 23 | 2022-01-27 | Cal Poly (238) | 59 | 55 | UC-San Diego (126) | Final | L | -4 |
| 24 | 2022-01-29 | Cal State-Bakersfield (333) | 75 | 83 | UC-San Diego (126) | Final | W | 8 |
| 25 | 2022-02-03 | UC-San Diego (126) | 83 | 77 | Cal State-Northridge (180) | Final | W | 6 |
| 26 | 2022-02-05 | UC-San Diego (126) | 48 | 84 | UC-Santa Barbara (171) | Final | L | -36 |
| 27 | 2022-02-10 | UC-Davis (170) | 0 | 0 | UC-San Diego (126) | Canceled | - | - |
| 28 | 2022-02-12 | UC-Riverside (292) | 62 | 85 | UC-San Diego (126) | Final | W | 23 |
| 29 | 2022-02-15 | UC-Irvine (138) | 56 | 50 | UC-San Diego (263) | Final | L | -6 |
| 30 | 2022-02-17 | Hawaii (109) | 65 | 53 | UC-San Diego (126) | Final | L | -12 |
| 31 | 2022-02-24 | UC-San Diego (269) | 87 | 103 | Long Beach State (154) | Final | L | -16 |
| 32 | 2022-02-26 | Cal State-Fullerton (166) | 76 | 81 | UC-San Diego (269) | Final | W | 5 |
| 33 | 2022-03-03 | UC-San Diego (261) | 72 | 70 | Cal State-Bakersfield (304) | Final | W | 2 |
| 34 | 2022-03-05 | UC-San Diego (261) | 76 | 80 | Cal Poly (338) | Final | L | -4 |