Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Central Washington | 50 | 83 | Washington (213) | Final | W | 33 |
| 2 | 2021-11-09 | Northern Illinois (337) | 71 | 64 | Washington (213) | Final | L | -7 |
| 3 | 2021-11-11 | Northern Arizona (316) | 62 | 73 | Washington (213) | Final | W | 11 |
| 4 | 2021-11-15 | Texas Southern (285) | 65 | 72 | Washington (211) | Final | W | 7 |
| 5 | 2021-11-18 | Wyoming (37) | 77 | 72 | Washington (211) | Final (OT) | L | -5 |
| 6 | 2021-11-22 | George Mason (86) | 74 | 77 | Washington (72) | Final | W | 3 |
| 7 | 2021-11-23 | Washington (195) | 87 | 76 | South Dakota State (89) | Final | W | 11 |
| 8 | 2021-11-24 | Nevada (67) | 81 | 62 | Washington (72) | Final | L | -19 |
| 9 | 2021-11-27 | Winthrop (244) | 82 | 74 | Washington (195) | Final | L | -8 |
| 10 | 2021-12-12 | Washington (72) | 0 | 0 | Gonzaga (11) | Cancelled | - | - |
| 11 | 2021-12-18 | Seattle (118) | 56 | 64 | Washington (72) | Final | W | 8 |
| 12 | 2021-12-21 | Utah Valley (91) | 68 | 52 | Washington (72) | Final | L | -16 |
| 13 | 2021-12-29 | Washington (72) | 0 | 0 | Washington State (179) | Postponed | - | - |
| 14 | 2022-01-03 | Washington (72) | 79 | 95 | Arizona (2) | Final | L | -16 |
| 15 | 2022-01-06 | Washington (72) | 74 | 68 | Utah (130) | Final | W | 6 |
| 16 | 2022-01-09 | Washington (153) | 64 | 78 | Colorado (58) | Final | L | -14 |
| 17 | 2022-01-12 | California (107) | 55 | 64 | Washington (153) | Final | W | 9 |
| 18 | 2022-01-15 | Stanford (60) | 64 | 67 | Washington (72) | Final | W | 3 |
| 19 | 2022-01-20 | Washington (72) | 82 | 72 | Oregon State (144) | Final | W | 10 |
| 20 | 2022-01-23 | Washington (121) | 56 | 84 | Oregon (53) | Final | L | -28 |
| 21 | 2022-01-27 | Colorado (73) | 58 | 60 | Washington (72) | Final | W | 2 |
| 22 | 2022-01-29 | Utah (130) | 73 | 77 | Washington (72) | Final/2OT | W | 4 |
| 23 | 2022-02-03 | Washington (72) | 84 | 63 | California (65) | Final | W | 21 |
| 24 | 2022-02-06 | Washington (72) | 69 | 87 | Stanford (60) | Final | L | -18 |
| 25 | 2022-02-10 | Arizona State (61) | 64 | 87 | Washington (72) | Final | W | 23 |
| 26 | 2022-02-12 | Arizona (2) | 92 | 68 | Washington (72) | Final | L | -24 |
| 27 | 2022-02-17 | Washington (72) | 69 | 79 | USC (71) | Final | L | -10 |
| 28 | 2022-02-19 | Washington (103) | 50 | 76 | UCLA (14) | Final | L | -26 |
| 29 | 2022-02-23 | Washington (109) | 70 | 78 | Washington State (76) | Final | L | -8 |
| 30 | 2022-02-26 | Washington State (76) | 70 | 78 | Washington (109) | Final | W | 8 |
| 31 | 2022-02-28 | UCLA (15) | 77 | 66 | Washington (107) | Final | L | -11 |
| 32 | 2022-03-03 | Oregon (56) | 67 | 78 | Washington (107) | Final | W | 11 |
| 33 | 2022-03-05 | Oregon State (277) | 67 | 78 | Washington (107) | Final | W | 11 |
| 34 | 2022-03-09 | Utah (138) | 70 | 82 | Washington (102) | Final | W | 12 |
| 35 | 2022-03-10 | Washington (102) | 61 | 65 | USC (24) | Final | L | -4 |