Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Carlow | 40 | 135 | James Madison (148) | Final | W | 95 |
| 2 | 2021-11-13 | Old Dominion (121) | 53 | 58 | James Madison (148) | Final | W | 5 |
| 3 | 2021-11-16 | James Madison (46) | 79 | 78 | Eastern Kentucky (99) | Final | W | 1 |
| 4 | 2021-11-19 | George Mason (86) | 64 | 67 | James Madison (202) | Final | W | 3 |
| 5 | 2021-11-22 | Kent State (107) | 74 | 69 | James Madison (202) | Final | L | -5 |
| 6 | 2021-11-23 | Wright State (282) | 76 | 78 | James Madison (11) | Final | W | 2 |
| 7 | 2021-11-24 | Murray State (116) | 74 | 62 | James Madison (202) | Final | L | -12 |
| 8 | 2021-11-28 | James Madison (104) | 69 | 65 | Florida Atlantic (253) | Final | W | 4 |
| 9 | 2021-12-02 | Eastern Mennonite | 54 | 96 | James Madison (104) | Final | W | 42 |
| 10 | 2021-12-07 | Virginia (14) | 49 | 52 | James Madison (202) | Final | W | 3 |
| 11 | 2021-12-11 | Radford (255) | 70 | 79 | James Madison (202) | Final | W | 9 |
| 12 | 2021-12-21 | James Madison (202) | 0 | 0 | Morgan State (337) | Cancelled | - | - |
| 13 | 2021-12-28 | James Madison (202) | 0 | 0 | Penn (131) | Cancelled | - | - |
| 14 | 2021-12-31 | James Madison (202) | 0 | 0 | Towson (152) | Postponed | - | - |
| 15 | 2022-01-03 | James Madison (202) | 0 | 0 | Delaware (287) | Postponed | - | - |
| 16 | 2022-01-09 | Hofstra (119) | 87 | 80 | James Madison (100) | Final | L | -7 |
| 17 | 2022-01-11 | Northeastern (300) | 66 | 89 | James Madison (202) | Final | W | 23 |
| 18 | 2022-01-15 | James Madison (202) | 95 | 91 | William & Mary (141) | Final/OT | W | 4 |
| 19 | 2022-01-17 | James Madison (99) | 67 | 90 | Elon (291) | Final | L | -23 |
| 20 | 2022-01-20 | UNC-Wilmington (90) | 71 | 70 | James Madison (202) | Final | L | -1 |
| 21 | 2022-01-22 | Charleston (123) | 94 | 95 | James Madison (202) | Final | W | 1 |
| 22 | 2022-01-27 | Drexel (215) | 88 | 82 | James Madison (202) | Final | L | -6 |
| 23 | 2022-01-29 | Delaware (287) | 85 | 69 | James Madison (202) | Final | L | -16 |
| 24 | 2022-02-03 | James Madison (202) | 76 | 71 | Northeastern (300) | Final | W | 5 |
| 25 | 2022-02-05 | James Madison (202) | 78 | 85 | Hofstra (98) | Final/OT | L | -7 |
| 26 | 2022-02-07 | James Madison (202) | 66 | 72 | Drexel (215) | Final | L | -6 |
| 27 | 2022-02-10 | Elon (232) | 70 | 66 | James Madison (202) | Final | L | -4 |
| 28 | 2022-02-12 | William & Mary (141) | 55 | 69 | James Madison (202) | Final | W | 14 |
| 29 | 2022-02-14 | James Madison (202) | 60 | 81 | Delaware (287) | Final | L | -21 |
| 30 | 2022-02-17 | James Madison (202) | 71 | 63 | Charleston (123) | Final | W | 8 |
| 31 | 2022-02-19 | James Madison (167) | 77 | 78 | UNC-Wilmington (145) | Final | L | -1 |
| 32 | 2022-02-23 | James Madison (170) | 65 | 84 | Towson (88) | Final | L | -19 |
| 33 | 2022-02-26 | Towson (88) | 95 | 59 | James Madison (170) | Final | L | -36 |