Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Trinity (TX) | 66 | 97 | UTSA (172) | Final | W | 31 |
| 2 | 2021-11-12 | UTSA (344) | 44 | 96 | Oklahoma (47) | Final | L | -52 |
| 3 | 2021-11-15 | Texas A&M-Commerce | 65 | 62 | UTSA (272) | Final | L | -3 |
| 4 | 2021-11-16 | Denver (357) | 64 | 78 | UTSA (272) | Final | W | 14 |
| 5 | 2021-11-17 | IUPUI (335) | 57 | 60 | UTSA (272) | Final | W | 3 |
| 6 | 2021-11-21 | Texas A&M-Corpus Christi (161) | 77 | 58 | UTSA (335) | Final | L | -19 |
| 7 | 2021-11-24 | Lamar (279) | 73 | 79 | UTSA (344) | Final | W | 6 |
| 8 | 2021-11-29 | Saint Mary's (TX) | 65 | 75 | UTSA (316) | Final | W | 10 |
| 9 | 2021-12-02 | UTSA (316) | 71 | 74 | Grand Canyon (102) | Final | L | -3 |
| 10 | 2021-12-11 | UTSA (344) | 78 | 73 | Sam Houston State (120) | Final | W | 5 |
| 11 | 2021-12-17 | UTRGV (161) | 68 | 50 | UTSA (344) | Final | L | -18 |
| 12 | 2021-12-21 | UTSA (344) | 64 | 81 | Illinois State (94) | Final | L | -17 |
| 13 | 2021-12-22 | Lady of the Lake | 0 | 0 | UTSA (344) | Cancelled | - | - |
| 14 | 2021-12-30 | UTSA (344) | 0 | 0 | Middle Tennessee (164) | Postponed | - | - |
| 15 | 2022-01-01 | UTSA (344) | 59 | 87 | UAB (115) | Final | L | -28 |
| 16 | 2022-01-03 | Dallas Christian | 48 | 101 | UTSA (344) | Final | W | 53 |
| 17 | 2022-01-06 | Southern Miss (201) | 74 | 73 | UTSA (344) | Final | L | -1 |
| 18 | 2022-01-08 | Louisiana Tech (185) | 79 | 63 | UTSA (344) | Final | L | -16 |
| 19 | 2022-01-13 | UTSA (344) | 51 | 83 | Old Dominion (254) | Final | L | -32 |
| 20 | 2022-01-15 | UTSA (344) | 53 | 62 | Charlotte (173) | Final | L | -9 |
| 21 | 2022-01-20 | UTSA (344) | 64 | 69 | UTEP (274) | Final | L | -5 |
| 22 | 2022-01-23 | UTEP (183) | 59 | 54 | UTSA (335) | Final | L | -5 |
| 23 | 2022-01-27 | Florida International (214) | 66 | 73 | UTSA (344) | Final | W | 7 |
| 24 | 2022-01-29 | Florida Atlantic (128) | 73 | 64 | UTSA (344) | Final | L | -9 |
| 25 | 2022-02-03 | UTSA (344) | 78 | 91 | Rice (228) | Final | L | -13 |
| 26 | 2022-02-05 | UTSA (344) | 45 | 69 | North Texas (125) | Final | L | -24 |
| 27 | 2022-02-07 | UTSA (344) | 75 | 84 | Middle Tennessee (164) | Final | L | -9 |
| 28 | 2022-02-12 | Western Kentucky (154) | 71 | 65 | UTSA (344) | Final | L | -6 |
| 29 | 2022-02-17 | UTSA (344) | 98 | 79 | Southern Miss (201) | Final/OT | W | 19 |
| 30 | 2022-02-19 | UTSA (331) | 71 | 95 | Louisiana Tech (97) | Final | L | -24 |
| 31 | 2022-02-24 | UAB (64) | 68 | 56 | UTSA (324) | Final | L | -12 |
| 32 | 2022-03-03 | North Texas (40) | 59 | 48 | UTSA (329) | Final | L | -11 |
| 33 | 2022-03-05 | Rice (192) | 71 | 82 | UTSA (329) | Final | W | 11 |
| 34 | 2022-03-08 | Southern Miss (337) | 67 | 64 | UTSA (314) | Final | L | -3 |