Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Georgetown (KY) | 63 | 93 | Eastern Kentucky (132) | Final | W | 30 |
| 2 | 2021-11-11 | Ohio Valley | 74 | 103 | Eastern Kentucky (132) | Final | W | 29 |
| 3 | 2021-11-13 | Eastern Kentucky (132) | 77 | 71 | Milwaukee (238) | Final | W | 6 |
| 4 | 2021-11-16 | James Madison (46) | 79 | 78 | Eastern Kentucky (99) | Final | L | -1 |
| 5 | 2021-11-20 | Albany (330) | 64 | 77 | Eastern Kentucky (288) | Final | W | 13 |
| 6 | 2021-11-22 | Eastern Illinois (314) | 43 | 82 | Eastern Kentucky (288) | Final | W | 39 |
| 7 | 2021-11-26 | Eastern Kentucky (288) | 77 | 80 | West Virginia (50) | Final | L | -3 |
| 8 | 2021-11-28 | Eastern Kentucky (219) | 75 | 88 | Radford (243) | Final | L | -13 |
| 9 | 2021-12-04 | Eastern Kentucky (288) | 80 | 85 | Western Kentucky (154) | Final | L | -5 |
| 10 | 2021-12-07 | Eastern Kentucky (288) | 68 | 80 | USC (71) | Final | L | -12 |
| 11 | 2021-12-11 | Marshall (155) | 80 | 69 | Eastern Kentucky (288) | Final | L | -11 |
| 12 | 2021-12-15 | Midway | 67 | 121 | Eastern Kentucky (288) | Final | W | 54 |
| 13 | 2021-12-18 | Northern Kentucky (195) | 68 | 81 | Eastern Kentucky (288) | Final/OT | W | 13 |
| 14 | 2021-12-22 | Eastern Kentucky (288) | 0 | 0 | Bryant (349) | Cancelled | - | - |
| 15 | 2021-12-31 | Alice Lloyd | 52 | 106 | Eastern Kentucky (288) | Final | W | 54 |
| 16 | 2022-01-04 | Central Arkansas (143) | 79 | 72 | Eastern Kentucky (288) | Final | L | -7 |
| 17 | 2022-01-08 | Eastern Kentucky (288) | 61 | 66 | Bellarmine (266) | Final | L | -5 |
| 18 | 2022-01-11 | Eastern Kentucky (288) | 75 | 76 | North Alabama (335) | Final | L | -1 |
| 19 | 2022-01-15 | Jacksonville State (227) | 76 | 65 | Eastern Kentucky (288) | Final | L | -11 |
| 20 | 2022-01-18 | Lipscomb (190) | 72 | 86 | Eastern Kentucky (288) | Final | W | 14 |
| 21 | 2022-01-22 | North Florida (345) | 58 | 67 | Eastern Kentucky (288) | Final | W | 9 |
| 22 | 2022-01-27 | Eastern Kentucky (288) | 73 | 77 | Florida Gulf Coast (241) | Final | L | -4 |
| 23 | 2022-01-29 | Eastern Kentucky (288) | 95 | 113 | Stetson (301) | Final | L | -18 |
| 24 | 2022-02-03 | Kennesaw State (142) | 81 | 82 | Eastern Kentucky (288) | Final/3OT | W | 1 |
| 25 | 2022-02-05 | Liberty (93) | 91 | 84 | Eastern Kentucky (288) | Final | L | -7 |
| 26 | 2022-02-09 | Eastern Kentucky (288) | 68 | 81 | Jacksonville (281) | Final | L | -13 |
| 27 | 2022-02-12 | Eastern Kentucky (288) | 73 | 83 | Lipscomb (190) | Final | L | -10 |
| 28 | 2022-02-16 | North Alabama (294) | 76 | 80 | Eastern Kentucky (275) | Final (OT) | W | 4 |
| 29 | 2022-02-19 | Eastern Kentucky (275) | 76 | 83 | Central Arkansas (290) | Final | L | -7 |
| 30 | 2022-02-23 | Eastern Kentucky (274) | 68 | 81 | Jacksonville State (140) | Final | L | -13 |
| 31 | 2022-02-26 | Bellarmine (186) | 58 | 72 | Eastern Kentucky (274) | Final | W | 14 |
| 32 | 2022-03-01 | Eastern Kentucky (273) | 73 | 82 | Kennesaw State (257) | Final | L | -9 |