Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Delta State | 60 | 68 | Southern Miss (281) | Final | W | 8 |
| 2 | 2021-11-09 | William Carey | 67 | 81 | Southern Miss (281) | Final | W | 14 |
| 3 | 2021-11-12 | Louisiana (290) | 66 | 45 | Southern Miss (201) | Final | L | -21 |
| 4 | 2021-11-15 | Southern Miss (284) | 51 | 83 | TCU (121) | Final | L | -32 |
| 5 | 2021-11-21 | Lamar (347) | 75 | 82 | Southern Miss (278) | Final | W | 7 |
| 6 | 2021-11-24 | Southern Miss (201) | 80 | 66 | UNC-Wilmington (90) | Final | W | 14 |
| 7 | 2021-11-25 | UC-San Diego (126) | 55 | 56 | Southern Miss (201) | Final | W | 1 |
| 8 | 2021-11-26 | Southern Miss (201) | 62 | 74 | Montana (230) | Final | L | -12 |
| 9 | 2021-12-01 | Southern Miss (201) | 55 | 85 | South Alabama (177) | Final | L | -30 |
| 10 | 2021-12-04 | Southern Miss (201) | 41 | 66 | Southern Illinois (150) | Final | L | -25 |
| 11 | 2021-12-11 | Loyola-New Orleans | 0 | 0 | Southern Miss (201) | Cancelled | - | - |
| 12 | 2021-12-11 | Loyola (LA) | 0 | 0 | Southern Miss (286) | Cancelled | - | - |
| 13 | 2021-12-14 | Jacksonville (281) | 62 | 51 | Southern Miss (201) | Final | L | -11 |
| 14 | 2021-12-18 | Southern Miss (201) | 65 | 74 | Louisiana-Monroe (358) | Final | L | -9 |
| 15 | 2021-12-21 | Southern Miss (201) | 67 | 68 | East Carolina (252) | Final | L | -1 |
| 16 | 2021-12-30 | Western Kentucky (154) | 0 | 0 | Southern Miss (201) | Postponed | - | - |
| 17 | 2022-01-01 | Marshall (155) | 0 | 0 | Southern Miss (201) | Postponed | - | - |
| 18 | 2022-01-06 | Southern Miss (201) | 74 | 73 | UTSA (344) | Final | W | 1 |
| 19 | 2022-01-08 | Southern Miss (201) | 54 | 87 | UTEP (274) | Final | L | -33 |
| 20 | 2022-01-13 | Southern Miss (201) | 57 | 80 | Louisiana Tech (185) | Final | L | -23 |
| 21 | 2022-01-16 | Louisiana Tech (75) | 76 | 62 | Southern Miss (303) | Final | L | -14 |
| 22 | 2022-01-19 | Southeast Baptist | 50 | 100 | Southern Miss (201) | Final | W | 50 |
| 23 | 2022-01-22 | Southern Miss (201) | 60 | 74 | Middle Tennessee (164) | Final | L | -14 |
| 24 | 2022-01-27 | North Texas (125) | 63 | 54 | Southern Miss (201) | Final | L | -9 |
| 25 | 2022-01-29 | Rice (228) | 76 | 62 | Southern Miss (201) | Final | L | -14 |
| 26 | 2022-02-03 | Southern Miss (201) | 67 | 77 | Florida International (214) | Final | L | -10 |
| 27 | 2022-02-05 | Southern Miss (201) | 57 | 84 | Florida Atlantic (128) | Final | L | -27 |
| 28 | 2022-02-10 | Southern Miss (201) | 63 | 84 | UAB (115) | Final | L | -21 |
| 29 | 2022-02-14 | Western Kentucky (154) | 87 | 77 | Southern Miss (201) | Final | L | -10 |
| 30 | 2022-02-17 | UTSA (344) | 98 | 79 | Southern Miss (201) | Final/OT | L | -19 |
| 31 | 2022-02-19 | UTEP (179) | 84 | 70 | Southern Miss (318) | Final | L | -14 |
| 32 | 2022-02-21 | Marshall (242) | 74 | 60 | Southern Miss (325) | Final | L | -14 |
| 33 | 2022-02-24 | Southern Miss (325) | 61 | 85 | North Texas (40) | Final | L | -24 |
| 34 | 2022-02-26 | Southern Miss (325) | 72 | 77 | Rice (184) | Final | L | -5 |
| 35 | 2022-03-02 | UAB (63) | 81 | 68 | Southern Miss (336) | Final | L | -13 |
| 36 | 2022-03-05 | Charlotte (149) | 70 | 67 | Southern Miss (336) | Final | L | -3 |
| 37 | 2022-03-08 | Southern Miss (337) | 67 | 64 | UTSA (314) | Final | W | 3 |
| 38 | 2022-03-09 | Southern Miss (337) | 59 | 86 | Florida Atlantic (159) | Final | L | -27 |