Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Florida International (303) | 51 | 58 | Georgia (92) | Final | L | -7 |
| 2 | 2021-11-12 | Trinity (FL) | 48 | 111 | Florida International (214) | Final | W | 63 |
| 3 | 2021-11-18 | Ball State (174) | 60 | 73 | Florida International (223) | Final | W | 13 |
| 4 | 2021-11-19 | Florida International (214) | 63 | 60 | Green Bay (206) | Final | W | 3 |
| 5 | 2021-11-21 | UNC-Greensboro (172) | 71 | 74 | Florida International (109) | Final (OT) | W | 3 |
| 6 | 2021-11-24 | North Dakota (251) | 56 | 65 | Florida International (214) | Final | W | 9 |
| 7 | 2021-11-28 | North Florida (318) | 69 | 84 | Florida International (94) | Final | W | 15 |
| 8 | 2021-12-01 | Florida Gulf Coast (241) | 61 | 77 | Florida International (214) | Final | W | 16 |
| 9 | 2021-12-04 | Stetson (301) | 65 | 72 | Florida International (214) | Final | W | 7 |
| 10 | 2021-12-11 | Florida International (214) | 88 | 92 | Eastern Michigan (277) | Final/4OT | L | -4 |
| 11 | 2021-12-15 | Florida International (214) | 59 | 66 | Jacksonville State (227) | Final | L | -7 |
| 12 | 2021-12-19 | Bethune-Cookman (240) | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 13 | 2021-12-20 | Albany State | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 14 | 2021-12-21 | Houston Christian (305) | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 15 | 2021-12-21 | Houston Baptist | 0 | 0 | Florida International | Cancelled | - | - |
| 16 | 2021-12-30 | Old Dominion (254) | 82 | 77 | Florida International (214) | Final | L | -5 |
| 17 | 2022-01-01 | St. Thomas (FL) | 72 | 95 | Florida International (214) | Final | W | 23 |
| 18 | 2022-01-05 | Bethune-Cookman (240) | 65 | 68 | Florida International (214) | Final | W | 3 |
| 19 | 2022-01-08 | Florida International (214) | 71 | 84 | Western Kentucky (154) | Final | L | -13 |
| 20 | 2022-01-13 | Florida International (214) | 56 | 84 | UAB (115) | Final | L | -28 |
| 21 | 2022-01-15 | Florida International (214) | 39 | 50 | Middle Tennessee (164) | Final | L | -11 |
| 22 | 2022-01-20 | Marshall (155) | 66 | 70 | Florida International (214) | Final | W | 4 |
| 23 | 2022-01-22 | Western Kentucky (154) | 83 | 86 | Florida International (214) | Final | W | 3 |
| 24 | 2022-01-27 | Florida International (214) | 66 | 73 | UTSA (344) | Final | L | -7 |
| 25 | 2022-01-29 | Florida International (214) | 68 | 79 | UTEP (274) | Final | L | -11 |
| 26 | 2022-02-03 | Southern Miss (201) | 67 | 77 | Florida International (214) | Final | W | 10 |
| 27 | 2022-02-05 | Louisiana Tech (185) | 86 | 82 | Florida International (214) | Final | L | -4 |
| 28 | 2022-02-07 | Charlotte (173) | 81 | 68 | Florida International (214) | Final | L | -13 |
| 29 | 2022-02-10 | Florida International (214) | 72 | 71 | Marshall (155) | Final | W | 1 |
| 30 | 2022-02-17 | Middle Tennessee (164) | 71 | 65 | Florida International (214) | Final | L | -6 |
| 31 | 2022-02-19 | Rice (168) | 78 | 80 | Florida International (209) | Final | W | 2 |
| 32 | 2022-02-24 | Florida International (203) | 55 | 64 | Charlotte (150) | Final | L | -9 |
| 33 | 2022-02-26 | Florida International (203) | 63 | 83 | Old Dominion (229) | Final | L | -20 |
| 34 | 2022-03-03 | Florida Atlantic (173) | 71 | 51 | Florida International (218) | Final | L | -20 |
| 35 | 2022-03-05 | Florida International (218) | 76 | 84 | Florida Atlantic (173) | Final | L | -8 |
| 36 | 2022-03-08 | Marshall (248) | 74 | 62 | Florida International (229) | Final | L | -12 |