Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Francis Marion | 72 | 101 | UNC-Wilmington (254) | Final | W | 29 |
| 2 | 2021-11-09 | UNC-Wilmington (254) | 63 | 68 | Illinois State (261) | Final | L | -5 |
| 3 | 2021-11-12 | Guilford | 68 | 77 | UNC-Wilmington (90) | Final | W | 9 |
| 4 | 2021-11-16 | UNC-Wilmington (303) | 51 | 59 | Pittsburgh (301) | Final | L | -8 |
| 5 | 2021-11-18 | Coastal Carolina (185) | 53 | 65 | UNC-Wilmington (303) | Final | W | 12 |
| 6 | 2021-11-20 | UNC-Wilmington (90) | 67 | 63 | Delaware State (361) | Final | W | 4 |
| 7 | 2021-11-24 | Southern Miss (201) | 80 | 66 | UNC-Wilmington (90) | Final | L | -14 |
| 8 | 2021-11-25 | UNC-Wilmington (90) | 0 | 0 | Montana (230) | Cancelled | - | - |
| 9 | 2021-11-26 | UC-San Diego (126) | 0 | 0 | UNC-Wilmington (90) | Cancelled | - | - |
| 10 | 2021-12-01 | Norfolk State (322) | 74 | 69 | UNC-Wilmington (90) | Final | L | -5 |
| 11 | 2021-12-11 | UNC-Wilmington (90) | 48 | 77 | Jacksonville (281) | Final | L | -29 |
| 12 | 2021-12-15 | Mount Olive | 55 | 85 | UNC-Wilmington (90) | Final | W | 30 |
| 13 | 2021-12-18 | UNC-Wilmington (90) | 71 | 69 | High Point (69) | Final/OT | W | 2 |
| 14 | 2021-12-22 | Campbell (191) | 58 | 65 | UNC-Wilmington (90) | Final | W | 7 |
| 15 | 2021-12-29 | Delaware (287) | 68 | 70 | UNC-Wilmington (90) | Final | W | 2 |
| 16 | 2021-12-31 | Drexel (215) | 0 | 0 | UNC-Wilmington (90) | Postponed | - | - |
| 17 | 2022-01-03 | UNC-Wilmington (90) | 0 | 0 | Hofstra (98) | Postponed | - | - |
| 18 | 2022-01-05 | UNC-Wilmington (90) | 0 | 0 | Northeastern (300) | Postponed | - | - |
| 19 | 2022-01-12 | Elon (285) | 66 | 73 | UNC-Wilmington (260) | Final | W | 7 |
| 20 | 2022-01-17 | UNC-Wilmington (239) | 86 | 78 | Charleston (124) | Final | W | 8 |
| 21 | 2022-01-20 | UNC-Wilmington (90) | 71 | 70 | James Madison (202) | Final | W | 1 |
| 22 | 2022-01-22 | UNC-Wilmington (90) | 81 | 77 | Towson (152) | Final/OT | W | 4 |
| 23 | 2022-01-24 | UNC-Wilmington (90) | 74 | 68 | Northeastern (300) | Final | W | 6 |
| 24 | 2022-01-27 | Northeastern (300) | 62 | 67 | UNC-Wilmington (90) | Final | W | 5 |
| 25 | 2022-01-29 | Hofstra (98) | 72 | 78 | UNC-Wilmington (90) | Final | W | 6 |
| 26 | 2022-02-03 | UNC-Wilmington (90) | 65 | 78 | Elon (232) | Final | L | -13 |
| 27 | 2022-02-05 | UNC-Wilmington (90) | 92 | 70 | William & Mary (141) | Final | W | 22 |
| 28 | 2022-02-07 | UNC-Wilmington (90) | 71 | 73 | Hofstra (98) | Final | L | -2 |
| 29 | 2022-02-12 | Charleston (123) | 79 | 85 | UNC-Wilmington (90) | Final | W | 6 |
| 30 | 2022-02-14 | William & Mary (141) | 73 | 80 | UNC-Wilmington (90) | Final/OT | W | 7 |
| 31 | 2022-02-17 | Towson (152) | 79 | 55 | UNC-Wilmington (90) | Final | L | -24 |
| 32 | 2022-02-19 | James Madison (167) | 77 | 78 | UNC-Wilmington (145) | Final | W | 1 |
| 33 | 2022-02-24 | UNC-Wilmington (147) | 69 | 63 | Drexel (165) | Final | W | 6 |
| 34 | 2022-02-26 | UNC-Wilmington (147) | 69 | 62 | Delaware (116) | Final | W | 7 |
| 35 | 2022-03-06 | Elon (253) | 58 | 75 | UNC-Wilmington (126) | Final | W | 17 |
| 36 | 2022-03-07 | Charleston (148) | 57 | 60 | UNC-Wilmington (126) | Final | W | 3 |
| 37 | 2022-03-08 | Delaware (134) | 59 | 55 | UNC-Wilmington (126) | Final | L | -4 |
| 38 | 2022-03-20 | Virginia Military (181) | 78 | 93 | UNC-Wilmington (131) | Final | W | 15 |
| 39 | 2022-03-21 | Drake (86) | 75 | 76 | UNC-Wilmington (131) | Final | W | 1 |
| 40 | 2022-03-22 | UNC-Wilmington (131) | 80 | 64 | Northern Colorado (209) | Final | W | 16 |
| 41 | 2022-03-23 | Middle Tennessee (106) | 90 | 96 | UNC-Wilmington (131) | Final (2OT) | W | 6 |