Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Trinity Baptist | 43 | 79 | Jacksonville (282) | Final | W | 36 |
| 2 | 2021-11-13 | North Carolina A&T (289) | 54 | 63 | Jacksonville (282) | Final | W | 9 |
| 3 | 2021-11-16 | Jacksonville (111) | 54 | 63 | Central Florida (85) | Final | L | -9 |
| 4 | 2021-11-24 | Jacksonville (281) | 44 | 55 | Minnesota (87) | Final | L | -11 |
| 5 | 2021-11-27 | Coastal Georgia | 54 | 83 | Jacksonville (177) | Final | W | 29 |
| 6 | 2021-12-02 | Jacksonville (209) | 67 | 56 | Charleston Southern (323) | Final | W | 11 |
| 7 | 2021-12-07 | Jacksonville (281) | 58 | 69 | Georgia (35) | Final | L | -11 |
| 8 | 2021-12-11 | UNC-Wilmington (90) | 48 | 77 | Jacksonville (281) | Final | W | 29 |
| 9 | 2021-12-14 | Jacksonville (281) | 62 | 51 | Southern Miss (201) | Final | W | 11 |
| 10 | 2021-12-18 | Webber International | 48 | 87 | Jacksonville (281) | Final | W | 39 |
| 11 | 2021-12-21 | Jacksonville (281) | 55 | 64 | Pittsburgh (108) | Final | L | -9 |
| 12 | 2021-12-29 | Carver Bible | 45 | 98 | Jacksonville (193) | Final | W | 53 |
| 13 | 2022-01-02 | Jacksonville (281) | 0 | 0 | Campbell (191) | Canceled | - | - |
| 14 | 2022-01-08 | Florida Gulf Coast (241) | 66 | 69 | Jacksonville (281) | Final | W | 3 |
| 15 | 2022-01-11 | Stetson (301) | 50 | 57 | Jacksonville (281) | Final | W | 7 |
| 16 | 2022-01-15 | Jacksonville (281) | 54 | 51 | North Florida (345) | Final | W | 3 |
| 17 | 2022-01-18 | Jacksonville (281) | 49 | 88 | Liberty (93) | Final | L | -39 |
| 18 | 2022-01-22 | Jacksonville (281) | 73 | 76 | Bellarmine (266) | Final/OT | L | -3 |
| 19 | 2022-01-24 | Jacksonville (281) | 68 | 76 | Kennesaw State (142) | Final | L | -8 |
| 20 | 2022-01-27 | Lipscomb (190) | 59 | 66 | Jacksonville (281) | Final | W | 7 |
| 21 | 2022-01-29 | Central Arkansas (143) | 59 | 79 | Jacksonville (281) | Final | W | 20 |
| 22 | 2022-02-03 | Jacksonville (281) | 56 | 50 | North Alabama (335) | Final | W | 6 |
| 23 | 2022-02-05 | Jacksonville (281) | 58 | 64 | Jacksonville State (227) | Final | L | -6 |
| 24 | 2022-02-09 | Eastern Kentucky (288) | 68 | 81 | Jacksonville (281) | Final | W | 13 |
| 25 | 2022-02-12 | Liberty (93) | 69 | 73 | Jacksonville (281) | Final | W | 4 |
| 26 | 2022-02-16 | Jacksonville (184) | 67 | 45 | Stetson (280) | Final | W | 22 |
| 27 | 2022-02-19 | Kennesaw State (252) | 56 | 59 | Jacksonville (184) | Final | W | 3 |
| 28 | 2022-02-23 | North Florida (260) | 39 | 71 | Jacksonville (171) | Final | W | 32 |
| 29 | 2022-02-26 | Jacksonville (171) | 69 | 76 | Florida Gulf Coast (188) | Final | L | -7 |
| 30 | 2022-03-03 | Central Arkansas (291) | 69 | 79 | Jacksonville (174) | Final | W | 10 |
| 31 | 2022-03-05 | Jacksonville (174) | 54 | 51 | Jacksonville State (134) | Final | W | 3 |
| 32 | 2022-03-08 | Jacksonville (161) | 72 | 77 | Bellarmine (178) | Final | L | -5 |