Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Davenport | 59 | 85 | Illinois State (261) | Final | W | 26 |
| 2 | 2021-11-09 | UNC-Wilmington (254) | 63 | 68 | Illinois State (261) | Final | W | 5 |
| 3 | 2021-11-12 | Illinois State (94) | 98 | 103 | Eastern Michigan (277) | Final/2OT | L | -5 |
| 4 | 2021-11-16 | Murray State (112) | 77 | 65 | Illinois State (201) | Final | L | -12 |
| 5 | 2021-11-20 | Bucknell (336) | 100 | 105 | Illinois State (94) | Final/OT | W | 5 |
| 6 | 2021-11-23 | Illinois State (213) | 76 | 82 | Saint Louis (70) | Final | L | -6 |
| 7 | 2021-11-24 | Buffalo (219) | 106 | 90 | Illinois State (94) | Final | L | -16 |
| 8 | 2021-11-27 | Purdue Northwest | 71 | 81 | Illinois State (213) | Final | W | 10 |
| 9 | 2021-12-01 | Missouri State (224) | 74 | 79 | Illinois State (94) | Final/OT | W | 5 |
| 10 | 2021-12-04 | Jackson State (329) | 61 | 55 | Illinois State (94) | Final | L | -6 |
| 11 | 2021-12-11 | Illinois State (94) | 81 | 71 | Chicago State (351) | Final | W | 10 |
| 12 | 2021-12-11 | Illinois State (268) | 80 | 71 | Chicago State (302) | Final | W | 9 |
| 13 | 2021-12-14 | Quincy | 63 | 81 | Illinois State (94) | Final | W | 18 |
| 14 | 2021-12-18 | Ball State (298) | 64 | 85 | Illinois State (94) | Final | W | 21 |
| 15 | 2021-12-21 | UTSA (344) | 64 | 81 | Illinois State (94) | Final | W | 17 |
| 16 | 2021-12-29 | Illinois State (94) | 85 | 89 | Wisconsin (24) | Final | L | -4 |
| 17 | 2022-01-02 | Illinois State (94) | 76 | 81 | Valparaiso (156) | Final/OT | L | -5 |
| 18 | 2022-01-05 | Loyola-Chicago (263) | 0 | 0 | Illinois State (94) | Postponed | - | - |
| 19 | 2022-01-12 | Illinois State (226) | 75 | 86 | Drake (110) | Final | L | -11 |
| 20 | 2022-01-16 | Bradley (191) | 65 | 74 | Illinois State (212) | Final | W | 9 |
| 21 | 2022-01-19 | Illinois State (94) | 63 | 88 | Missouri State (224) | Final | L | -25 |
| 22 | 2022-01-21 | Evansville (318) | 56 | 94 | Illinois State (212) | Final | W | 38 |
| 23 | 2022-01-23 | Illinois State (218) | 53 | 56 | Evansville (310) | Final | L | -3 |
| 24 | 2022-01-26 | Drake (109) | 89 | 88 | Illinois State (218) | Final (OT) | L | -1 |
| 25 | 2022-01-29 | Illinois State (94) | 64 | 79 | Northern Iowa (89) | Final | L | -15 |
| 26 | 2022-02-02 | Illinois State (228) | 64 | 78 | Loyola-Chicago (42) | Final | L | -14 |
| 27 | 2022-02-05 | Southern Illinois (150) | 75 | 69 | Illinois State (94) | Final | L | -6 |
| 28 | 2022-02-09 | Valparaiso (156) | 75 | 78 | Illinois State (94) | Final/OT | W | 3 |
| 29 | 2022-02-12 | Illinois State (94) | 57 | 60 | Indiana State (243) | Final | L | -3 |
| 30 | 2022-02-15 | Northern Iowa (119) | 72 | 70 | Illinois State (248) | Final | L | -2 |
| 31 | 2022-02-19 | Illinois State (248) | 64 | 72 | Bradley (124) | Final | L | -8 |
| 32 | 2022-02-21 | Loyola-Chicago (50) | 59 | 50 | Illinois State (254) | Final | L | -9 |
| 33 | 2022-02-23 | Illinois State (254) | 69 | 90 | Southern Illinois (169) | Final | L | -21 |
| 34 | 2022-02-26 | Indiana State (243) | 66 | 86 | Illinois State (254) | Final | W | 20 |
| 35 | 2022-03-03 | Indiana State (260) | 53 | 58 | Illinois State (253) | Final | W | 5 |
| 36 | 2022-03-04 | Illinois State (253) | 65 | 78 | Northern Iowa (105) | Final | L | -13 |