Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Ferrum | 73 | 101 | Coastal Carolina (123) | Final | W | 28 |
| 2 | 2021-11-18 | Coastal Carolina (185) | 53 | 65 | UNC-Wilmington (303) | Final | L | -12 |
| 3 | 2021-11-23 | Coastal Carolina (294) | 64 | 61 | Valparaiso (340) | Final | W | 3 |
| 4 | 2021-11-24 | Coastal Carolina (188) | 70 | 79 | Toledo (135) | Final | L | -9 |
| 5 | 2021-12-01 | South Carolina (110) | 56 | 80 | Coastal Carolina (188) | Final | W | 24 |
| 6 | 2021-12-04 | Winthrop (133) | 64 | 74 | Coastal Carolina (188) | Final | W | 10 |
| 7 | 2021-12-06 | Mercer (208) | 74 | 69 | Coastal Carolina (143) | Final | L | -5 |
| 8 | 2021-12-12 | Wofford (221) | 59 | 60 | Coastal Carolina (188) | Final | W | 1 |
| 9 | 2021-12-15 | Methodist | 42 | 102 | Coastal Carolina (188) | Final | W | 60 |
| 10 | 2021-12-16 | Regent | 53 | 110 | Coastal Carolina (188) | Final | W | 57 |
| 11 | 2021-12-19 | Coastal Carolina (188) | 80 | 84 | Middle Tennessee (164) | Final | L | -4 |
| 12 | 2021-12-30 | Louisiana-Monroe (358) | 64 | 94 | Coastal Carolina (188) | Final | W | 30 |
| 13 | 2022-01-01 | Louisiana (290) | 65 | 64 | Coastal Carolina (188) | Final | L | -1 |
| 14 | 2022-01-02 | Emory & Henry | 62 | 76 | Coastal Carolina (188) | Final | W | 14 |
| 15 | 2022-01-06 | Coastal Carolina (188) | 59 | 69 | Troy (127) | Final | L | -10 |
| 16 | 2022-01-08 | Coastal Carolina (188) | 0 | 0 | South Alabama (177) | Canceled | - | - |
| 17 | 2022-01-13 | Coastal Carolina (188) | 60 | 61 | Appalachian State (159) | Final | L | -1 |
| 18 | 2022-01-15 | Appalachian State (159) | 84 | 76 | Coastal Carolina (188) | Final/OT | L | -8 |
| 19 | 2022-01-20 | Coastal Carolina (188) | 76 | 72 | Georgia Southern (216) | Final | W | 4 |
| 20 | 2022-01-22 | Coastal Carolina (188) | 72 | 68 | Georgia State (299) | Final/OT | W | 4 |
| 21 | 2022-01-27 | Little Rock (321) | 49 | 65 | Coastal Carolina (188) | Final | W | 16 |
| 22 | 2022-01-29 | Arkansas State (147) | 73 | 66 | Coastal Carolina (188) | Final | L | -7 |
| 23 | 2022-02-03 | Coastal Carolina (188) | 0 | 0 | Texas-Arlington (162) | Canceled | - | - |
| 24 | 2022-02-05 | Coastal Carolina (188) | 64 | 69 | Texas State (199) | Final | L | -5 |
| 25 | 2022-02-10 | Georgia State (299) | 61 | 50 | Coastal Carolina (188) | Final | L | -11 |
| 26 | 2022-02-12 | Georgia Southern (216) | 58 | 79 | Coastal Carolina (188) | Final | W | 21 |
| 27 | 2022-02-17 | South Alabama (177) | 71 | 68 | Coastal Carolina (188) | Final | L | -3 |
| 28 | 2022-02-19 | Troy (155) | 63 | 73 | Coastal Carolina (178) | Final | W | 10 |
| 29 | 2022-02-23 | Coastal Carolina (172) | 74 | 69 | Arkansas State (176) | Final | W | 5 |
| 30 | 2022-02-25 | Coastal Carolina (172) | 68 | 55 | Little Rock (295) | Final | W | 13 |
| 31 | 2022-03-03 | Georgia Southern (251) | 70 | 64 | Coastal Carolina (157) | Final | L | -6 |
| 32 | 2022-03-16 | Maryland-Eastern Shore (353) | 42 | 66 | Coastal Carolina (188) | Final | W | 24 |
| 33 | 2022-03-21 | Florida Gulf Coast (180) | 68 | 84 | Coastal Carolina (172) | Final | W | 16 |
| 34 | 2022-03-28 | Coastal Carolina (172) | 69 | 68 | South Alabama (156) | Final | W | 1 |
| 35 | 2022-04-01 | Fresno State (91) | 85 | 74 | Coastal Carolina (172) | Final | L | -11 |