Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Long Island (210) | 64 | 98 | San Francisco (124) | Final | W | 34 |
| 2 | 2021-11-11 | Prairie View A&M (168) | 76 | 92 | San Francisco (124) | Final | W | 16 |
| 3 | 2021-11-13 | Davidson (74) | 60 | 65 | San Francisco (124) | Final | W | 5 |
| 4 | 2021-11-15 | Samford (202) | 55 | 77 | San Francisco (19) | Final | W | 22 |
| 5 | 2021-11-18 | Nevada (162) | 70 | 73 | San Francisco (19) | Final | W | 3 |
| 6 | 2021-11-22 | Morgan State (337) | 67 | 83 | San Francisco (122) | Final | W | 16 |
| 7 | 2021-11-25 | San Francisco (122) | 71 | 61 | Towson (152) | Final | W | 10 |
| 8 | 2021-11-26 | San Francisco (122) | 63 | 61 | UAB (115) | Final | W | 2 |
| 9 | 2021-12-04 | UNLV (105) | 62 | 83 | San Francisco (122) | Final | W | 21 |
| 10 | 2021-12-08 | Fresno State (93) | 63 | 71 | San Francisco (8) | Final | W | 8 |
| 11 | 2021-12-18 | San Francisco (122) | 48 | 49 | Grand Canyon (74) | Final | L | -1 |
| 12 | 2021-12-19 | San Francisco (122) | 66 | 65 | Arizona State (61) | Final | W | 1 |
| 13 | 2021-12-22 | Southern Illinois (150) | 52 | 64 | San Francisco (122) | Final | W | 12 |
| 14 | 2021-12-28 | Academy of Art | 78 | 111 | San Francisco (122) | Final | W | 33 |
| 15 | 2022-01-01 | San Francisco (122) | 0 | 0 | Saint Mary's (33) | Postponed | - | - |
| 16 | 2022-01-06 | Loyola-Chicago (263) | 79 | 74 | San Francisco (122) | Final | L | -5 |
| 17 | 2022-01-08 | San Diego (246) | 73 | 88 | San Francisco (122) | Final | W | 15 |
| 18 | 2022-01-13 | Loyola Marymount (184) | 73 | 97 | San Francisco (122) | Final | W | 24 |
| 19 | 2022-01-15 | BYU (23) | 71 | 69 | San Francisco (122) | Final | L | -2 |
| 20 | 2022-01-20 | San Francisco (122) | 62 | 78 | Gonzaga (11) | Final | L | -16 |
| 21 | 2022-01-22 | San Francisco (122) | 71 | 45 | Pepperdine (283) | Final | W | 26 |
| 22 | 2022-01-27 | Saint Mary's (33) | 72 | 70 | San Francisco (122) | Final | L | -2 |
| 23 | 2022-01-29 | Santa Clara (42) | 85 | 88 | San Francisco (122) | Final | W | 3 |
| 24 | 2022-02-03 | San Francisco (122) | 73 | 59 | BYU (23) | Final | W | 14 |
| 25 | 2022-02-05 | San Francisco (122) | 74 | 71 | Portland (210) | Final | W | 3 |
| 26 | 2022-02-08 | Portland (226) | 69 | 68 | San Francisco (32) | Final | L | -1 |
| 27 | 2022-02-10 | Pepperdine (283) | 61 | 105 | San Francisco (122) | Final | W | 44 |
| 28 | 2022-02-12 | San Francisco (122) | 74 | 58 | Santa Clara (42) | Final | W | 16 |
| 29 | 2022-02-17 | San Francisco (122) | 64 | 69 | Saint Mary's (33) | Final | L | -5 |
| 30 | 2022-02-21 | San Francisco (38) | 104 | 71 | Pacific (294) | Final | W | 33 |
| 31 | 2022-02-24 | Gonzaga (1) | 89 | 73 | San Francisco (38) | Final | L | -16 |
| 32 | 2022-02-26 | San Francisco (38) | 78 | 62 | San Diego (192) | Final | W | 16 |
| 33 | 2022-03-05 | BYU (59) | 63 | 75 | San Francisco (37) | Final | W | 12 |
| 34 | 2022-03-07 | San Francisco (33) | 71 | 81 | Gonzaga (2) | Final | L | -10 |
| 35 | 2022-03-17 | San Francisco (33) | 87 | 92 | Murray State (20) | Final (OT) | L | -5 |