Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cal State-Fullerton (257) | 77 | 84 | Santa Clara (126) | Final | W | 7 |
| 2 | 2021-11-12 | Stanford (60) | 72 | 88 | Santa Clara (42) | Final | W | 16 |
| 3 | 2021-11-16 | Nevada (162) | 74 | 96 | Santa Clara (55) | Final | W | 22 |
| 4 | 2021-11-19 | Cal Poly (238) | 57 | 87 | Santa Clara (42) | Final | W | 30 |
| 5 | 2021-11-22 | Santa Clara (42) | 85 | 66 | TCU (32) | Final | W | 19 |
| 6 | 2021-11-25 | Fresno State (153) | 59 | 52 | Santa Clara (42) | Final | L | -7 |
| 7 | 2021-11-27 | UC-Irvine (63) | 69 | 64 | Santa Clara (23) | Final | L | -5 |
| 8 | 2021-11-30 | Hawaii (216) | 58 | 70 | Santa Clara (65) | Final | W | 12 |
| 9 | 2021-12-04 | Louisiana Tech (185) | 78 | 75 | Santa Clara (42) | Final | L | -3 |
| 10 | 2021-12-07 | Mount St Mary's (257) | 77 | 88 | Santa Clara (42) | Final | W | 11 |
| 11 | 2021-12-11 | Santa Clara (42) | 60 | 72 | California (65) | Final | L | -12 |
| 12 | 2021-12-14 | Santa Clara (42) | 60 | 72 | Boise State (62) | Final | L | -12 |
| 13 | 2021-12-17 | Florida A&M (297) | 66 | 80 | Santa Clara (42) | Final | W | 14 |
| 14 | 2021-12-19 | Montana (230) | 64 | 79 | Santa Clara (42) | Final | W | 15 |
| 15 | 2021-12-21 | Santa Clara (42) | 79 | 57 | San Jose State (229) | Final | W | 22 |
| 16 | 2021-12-30 | Santa Clara (42) | 0 | 0 | Pacific (132) | Postponed | - | - |
| 17 | 2022-01-01 | San Diego (246) | 0 | 0 | Santa Clara (42) | Postponed | - | - |
| 18 | 2022-01-06 | Saint Mary's (33) | 0 | 0 | Santa Clara (42) | Postponed | - | - |
| 19 | 2022-01-08 | Santa Clara (42) | 0 | 0 | Pacific (132) | Postponed | - | - |
| 20 | 2022-01-12 | Santa Clara (84) | 84 | 70 | Pacific (308) | Final | W | 14 |
| 21 | 2022-01-15 | Gonzaga (11) | 115 | 83 | Santa Clara (42) | Final | L | -32 |
| 22 | 2022-01-20 | Santa Clara (42) | 65 | 73 | Saint Mary's (33) | Final | L | -8 |
| 23 | 2022-01-24 | San Diego (246) | 74 | 78 | Santa Clara (42) | Final/OT | W | 4 |
| 24 | 2022-01-27 | BYU (23) | 76 | 77 | Santa Clara (42) | Final | W | 1 |
| 25 | 2022-01-29 | Santa Clara (42) | 85 | 88 | San Francisco (122) | Final | L | -3 |
| 26 | 2022-01-31 | Pacific (318) | 59 | 81 | Santa Clara (77) | Final | W | 22 |
| 27 | 2022-02-03 | Loyola Marymount (184) | 60 | 79 | Santa Clara (42) | Final | W | 19 |
| 28 | 2022-02-05 | Santa Clara (42) | 79 | 66 | San Diego (246) | Final | W | 13 |
| 29 | 2022-02-08 | Saint Mary's (27) | 72 | 77 | Santa Clara (74) | Final | W | 5 |
| 30 | 2022-02-12 | San Francisco (122) | 74 | 58 | Santa Clara (42) | Final | L | -16 |
| 31 | 2022-02-14 | Santa Clara (42) | 0 | 0 | Portland (210) | Canceled | - | - |
| 32 | 2022-02-17 | Santa Clara (42) | 84 | 80 | Loyola Marymount (184) | Final | W | 4 |
| 33 | 2022-02-19 | Santa Clara (74) | 69 | 81 | Gonzaga (2) | Final | L | -12 |
| 34 | 2022-02-24 | Santa Clara (75) | 89 | 73 | Pepperdine (286) | Final | W | 16 |
| 35 | 2022-02-26 | Portland (180) | 89 | 102 | Santa Clara (75) | Final | W | 13 |
| 36 | 2022-03-06 | Portland (176) | 67 | 91 | Santa Clara (68) | Final | W | 24 |
| 37 | 2022-03-07 | Santa Clara (68) | 72 | 75 | Saint Mary's (21) | Final | L | -3 |
| 38 | 2022-03-15 | Santa Clara (70) | 50 | 63 | Washington State (69) | Final | L | -13 |