Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Anderson (IN) | 60 | 74 | IUPUI (263) | Final | W | 14 |
| 2 | 2021-11-09 | IUPUI (263) | 47 | 56 | Butler (115) | Final | L | -9 |
| 3 | 2021-11-11 | IUPUI (263) | 40 | 60 | Evansville (225) | Final | L | -20 |
| 4 | 2021-11-15 | IUPUI (335) | 47 | 63 | Denver (357) | Final | L | -16 |
| 5 | 2021-11-16 | IUPUI (335) | 59 | 65 | Texas A&M-Corpus Christi (239) | Final | L | -6 |
| 6 | 2021-11-17 | IUPUI (335) | 57 | 60 | UTSA (272) | Final | L | -3 |
| 7 | 2021-11-23 | Spalding | 41 | 61 | IUPUI (357) | Final | W | 20 |
| 8 | 2021-12-02 | Detroit (314) | 69 | 45 | IUPUI (355) | Final | L | -24 |
| 9 | 2021-12-04 | Oakland (47) | 78 | 45 | IUPUI (355) | Final | L | -33 |
| 10 | 2021-12-10 | IUPUI (354) | 44 | 70 | Tennessee State (343) | Final | L | -26 |
| 11 | 2021-12-16 | Chicago State (293) | 61 | 55 | IUPUI (357) | Final | L | -6 |
| 12 | 2021-12-21 | Morehead State (146) | 80 | 52 | IUPUI (357) | Final | L | -28 |
| 13 | 2021-12-30 | Cleveland State | 0 | 0 | IUPUI | Cancelled | - | - |
| 14 | 2022-01-08 | IUPUI (357) | 58 | 72 | Wright State (257) | Final | L | -14 |
| 15 | 2022-01-10 | Illinois-Chicago (281) | 67 | 65 | IUPUI (357) | Final | L | -2 |
| 16 | 2022-01-13 | IUPUI (357) | 54 | 69 | Green Bay (344) | Final | L | -15 |
| 17 | 2022-01-15 | IUPUI (357) | 54 | 89 | Milwaukee (314) | Final | L | -35 |
| 18 | 2022-01-18 | IUPUI (358) | 37 | 83 | Ohio State (22) | Final | L | -46 |
| 19 | 2022-01-20 | Wright State (246) | 73 | 45 | IUPUI (358) | Final | L | -28 |
| 20 | 2022-01-22 | Northern Kentucky (297) | 60 | 41 | IUPUI (358) | Final | L | -19 |
| 21 | 2022-01-31 | East-West University | 59 | 75 | IUPUI (358) | Final | W | 16 |
| 22 | 2022-02-03 | Youngstown State (243) | 61 | 55 | IUPUI (358) | Final | L | -6 |
| 23 | 2022-02-05 | Robert Morris (325) | 66 | 49 | IUPUI (358) | Final | L | -17 |
| 24 | 2022-02-10 | IUPUI (358) | 57 | 72 | Purdue Fort Wayne (238) | Final | L | -15 |
| 25 | 2022-02-12 | IUPUI (358) | 45 | 83 | Cleveland State (130) | Final | L | -38 |
| 26 | 2022-02-14 | IUPUI (358) | 54 | 57 | Illinois-Chicago (279) | Final | L | -3 |
| 27 | 2022-02-17 | IUPUI (358) | 66 | 56 | Robert Morris (320) | Final | W | 10 |
| 28 | 2022-02-19 | IUPUI (358) | 61 | 74 | Youngstown State (235) | Final | L | -13 |
| 29 | 2022-02-24 | Milwaukee (321) | 66 | 54 | IUPUI (357) | Final | L | -12 |
| 30 | 2022-02-26 | Green Bay (349) | 67 | 41 | IUPUI (357) | Final | L | -26 |
| 31 | 2022-03-01 | IUPUI (357) | 58 | 70 | Oakland (148) | Final | L | -12 |