Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-29 | Akron (122) | 0 | 0 | West Virginia (17) | Cancelled | - | - |
| 2 | 2021-11-09 | Akron (122) | 66 | 67 | Ohio State (9) | Final | L | -1 |
| 3 | 2021-11-13 | Point Park | 46 | 102 | Akron (122) | Final | W | 56 |
| 4 | 2021-11-18 | Wheeling Jesuit | 38 | 99 | Akron (196) | Final | W | 61 |
| 5 | 2021-11-22 | Fordham (183) | 63 | 43 | Akron (59) | Final | L | -20 |
| 6 | 2021-11-23 | Appalachian State (164) | 57 | 45 | Akron (155) | Final | L | -12 |
| 7 | 2021-11-24 | Akron (59) | 69 | 60 | Evansville (302) | Final | W | 9 |
| 8 | 2021-12-01 | Marshall (155) | 86 | 88 | Akron (59) | Final | W | 2 |
| 9 | 2021-12-04 | Southern (259) | 62 | 79 | Akron (59) | Final | W | 17 |
| 10 | 2021-12-12 | Florida A&M (297) | 66 | 73 | Akron (59) | Final | W | 7 |
| 11 | 2021-12-15 | Akron (59) | 66 | 48 | Wright State (124) | Final | W | 18 |
| 12 | 2021-12-20 | Radford (255) | 0 | 0 | Akron (59) | Cancelled | - | - |
| 13 | 2021-12-29 | Akron (59) | 0 | 0 | Bowling Green (168) | Postponed | - | - |
| 14 | 2022-01-01 | Buffalo (219) | 76 | 88 | Akron (59) | Final | W | 12 |
| 15 | 2022-01-04 | Ohio (218) | 69 | 63 | Akron (59) | Final | L | -6 |
| 16 | 2022-01-08 | Akron (59) | 0 | 0 | Miami (OH) (40) | Postponed | - | - |
| 17 | 2022-01-11 | Ball State (298) | 74 | 84 | Akron (59) | Final | W | 10 |
| 18 | 2022-01-14 | Akron (128) | 55 | 67 | Kent State (166) | Final | L | -12 |
| 19 | 2022-01-18 | Western Michigan (304) | 73 | 74 | Akron (59) | Final | W | 1 |
| 20 | 2022-01-20 | Akron (59) | 91 | 66 | Bowling Green (168) | Final | W | 25 |
| 21 | 2022-01-22 | Eastern Michigan (277) | 44 | 46 | Akron (59) | Final | W | 2 |
| 22 | 2022-01-25 | Akron (125) | 60 | 56 | Central Michigan (340) | Final | W | 4 |
| 23 | 2022-01-28 | Akron (125) | 76 | 84 | Toledo (65) | Final | L | -8 |
| 24 | 2022-02-04 | Miami (OH) (244) | 55 | 66 | Akron (127) | Final | W | 11 |
| 25 | 2022-02-06 | Akron (59) | 71 | 59 | Miami (OH) (40) | Final | W | 12 |
| 26 | 2022-02-08 | Akron (121) | 70 | 64 | Northern Illinois (299) | Final | W | 6 |
| 27 | 2022-02-11 | Kent State (107) | 66 | 64 | Akron (59) | Final | L | -2 |
| 28 | 2022-02-12 | Kent State (159) | 66 | 64 | Akron (121) | Final | L | -2 |
| 29 | 2022-02-15 | Akron (128) | 57 | 61 | Western Michigan (346) | Final (OT) | L | -4 |
| 30 | 2022-02-17 | Northern Illinois (326) | 66 | 63 | Akron (59) | Final | L | -3 |
| 31 | 2022-02-19 | Akron (128) | 67 | 48 | Eastern Michigan (277) | Final | W | 19 |
| 32 | 2022-02-22 | Bowling Green (253) | 68 | 82 | Akron (156) | Final | W | 14 |
| 33 | 2022-02-25 | Akron (156) | 91 | 83 | Ohio (77) | Final | W | 8 |
| 34 | 2022-03-01 | Akron (138) | 79 | 60 | Ball State (252) | Final | W | 19 |
| 35 | 2022-03-04 | Central Michigan (305) | 56 | 57 | Akron (138) | Final | W | 1 |
| 36 | 2022-03-10 | Buffalo (122) | 68 | 70 | Akron (132) | Final | W | 2 |
| 37 | 2022-03-11 | Akron (132) | 70 | 62 | Toledo (69) | Final | W | 8 |
| 38 | 2022-03-12 | Akron (132) | 75 | 55 | Kent State (115) | Final | W | 20 |
| 39 | 2022-03-17 | Akron (116) | 53 | 57 | UCLA (10) | Final | L | -4 |