Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Fort Valley State | 61 | 93 | Mercer (128) | Final | W | 32 |
| 2 | 2021-11-09 | Mercer (128) | 61 | 74 | Arkansas (8) | Final | L | -13 |
| 3 | 2021-11-13 | Mercer (128) | 85 | 88 | Winthrop (49) | Final (OT) | L | -3 |
| 4 | 2021-11-16 | Life | 50 | 78 | Mercer (298) | Final | W | 28 |
| 5 | 2021-11-20 | Mercer (174) | 58 | 75 | Saint Louis (31) | Final | L | -17 |
| 6 | 2021-11-23 | Bucknell (284) | 68 | 78 | Mercer (309) | Final | W | 10 |
| 7 | 2021-11-24 | Middle Tennessee (164) | 82 | 58 | Mercer (174) | Final | L | -24 |
| 8 | 2021-11-27 | Milligan | 49 | 88 | Mercer (309) | Final | W | 39 |
| 9 | 2021-12-01 | Mercer (174) | 73 | 71 | Kennesaw State (142) | Final | W | 2 |
| 10 | 2021-12-04 | Georgia State (299) | 77 | 83 | Mercer (174) | Final | W | 6 |
| 11 | 2021-12-06 | Mercer (208) | 74 | 69 | Coastal Carolina (143) | Final | W | 5 |
| 12 | 2021-12-11 | Georgia Southern (216) | 68 | 77 | Mercer (174) | Final | W | 9 |
| 13 | 2021-12-19 | Mercer (174) | 55 | 67 | Florida Gulf Coast (241) | Final | L | -12 |
| 14 | 2021-12-22 | Troy (127) | 69 | 65 | Mercer (174) | Final | L | -4 |
| 15 | 2021-12-29 | Mercer (174) | 0 | 0 | The Citadel (332) | Postponed | - | - |
| 16 | 2022-01-01 | Chattanooga (291) | 0 | 0 | Mercer (174) | Postponed | - | - |
| 17 | 2022-01-05 | Samford (203) | 80 | 83 | Mercer (174) | Final | W | 3 |
| 18 | 2022-01-08 | Mercer (174) | 66 | 81 | Furman (157) | Final | L | -15 |
| 19 | 2022-01-13 | Virginia Military (357) | 91 | 97 | Mercer (174) | Final | W | 6 |
| 20 | 2022-01-15 | UNC-Greensboro (265) | 49 | 58 | Mercer (174) | Final | W | 9 |
| 21 | 2022-01-17 | Mercer (173) | 71 | 64 | The Citadel (250) | Final | W | 7 |
| 22 | 2022-01-19 | Mercer (174) | 64 | 72 | East Tennessee State (140) | Final | L | -8 |
| 23 | 2022-01-22 | Western Carolina (223) | 64 | 72 | Mercer (174) | Final | W | 8 |
| 24 | 2022-01-26 | Mercer (172) | 61 | 75 | Samford (216) | Final | L | -14 |
| 25 | 2022-01-29 | Furman (157) | 80 | 50 | Mercer (174) | Final | L | -30 |
| 26 | 2022-01-31 | Wofford (126) | 62 | 67 | Mercer (190) | Final | W | 5 |
| 27 | 2022-02-05 | Mercer (174) | 68 | 77 | Chattanooga (291) | Final | L | -9 |
| 28 | 2022-02-07 | Chattanooga (291) | 74 | 72 | Mercer (174) | Final/OT | L | -2 |
| 29 | 2022-02-10 | Mercer (174) | 79 | 85 | Virginia Military (357) | Final | L | -6 |
| 30 | 2022-02-13 | Mercer (175) | 73 | 64 | UNC-Greensboro (160) | Final | W | 9 |
| 31 | 2022-02-16 | East Tennessee State (174) | 56 | 65 | Mercer (175) | Final | W | 9 |
| 32 | 2022-02-19 | Mercer (175) | 65 | 69 | Western Carolina (274) | Final | L | -4 |
| 33 | 2022-02-23 | The Citadel (236) | 71 | 67 | Mercer (179) | Final | L | -4 |
| 34 | 2022-02-26 | Mercer (179) | 67 | 74 | Wofford (132) | Final | L | -7 |
| 35 | 2022-03-04 | Western Carolina (258) | 53 | 81 | Mercer (194) | Final | W | 28 |
| 36 | 2022-03-05 | Mercer (194) | 66 | 80 | Furman (101) | Final | L | -14 |