Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cumberland | 77 | 109 | Murray State (211) | Final | W | 32 |
| 2 | 2021-11-13 | Bellarmine (158) | 59 | 78 | Murray State (211) | Final | W | 19 |
| 3 | 2021-11-16 | Murray State (112) | 77 | 65 | Illinois State (201) | Final | W | 12 |
| 4 | 2021-11-22 | Murray State (116) | 58 | 66 | East Tennessee State (140) | Final | L | -8 |
| 5 | 2021-11-23 | Long Beach State (229) | 43 | 80 | Murray State (90) | Final | W | 37 |
| 6 | 2021-11-24 | Murray State (116) | 74 | 62 | James Madison (202) | Final | W | 12 |
| 7 | 2021-11-29 | Campbellsville - Harrodsburg | 61 | 98 | Murray State (81) | Final | W | 37 |
| 8 | 2021-12-04 | Middle Tennessee (164) | 87 | 93 | Murray State (116) | Final | W | 6 |
| 9 | 2021-12-10 | Murray State (65) | 74 | 72 | Memphis (67) | Final | W | 2 |
| 10 | 2021-12-15 | Tennessee Wesleyan | 48 | 118 | Murray State (116) | Final | W | 70 |
| 11 | 2021-12-18 | Chattanooga (291) | 76 | 87 | Murray State (116) | Final | W | 11 |
| 12 | 2021-12-22 | Murray State (116) | 58 | 71 | Auburn (37) | Final | L | -13 |
| 13 | 2021-12-30 | Southeast Missouri State (226) | 81 | 106 | Murray State (116) | Final | W | 25 |
| 14 | 2022-01-01 | Tennessee Tech (310) | 0 | 0 | Murray State (116) | Postponed | - | - |
| 15 | 2022-01-06 | Murray State (116) | 0 | 0 | Eastern Illinois (314) | Postponed | - | - |
| 16 | 2022-01-08 | Murray State (116) | 74 | 69 | SIU-Edwardsville (248) | Final | W | 5 |
| 17 | 2022-01-13 | Tennessee State (165) | 44 | 67 | Murray State (116) | Final | W | 23 |
| 18 | 2022-01-15 | Murray State (116) | 82 | 60 | Belmont (68) | Final | W | 22 |
| 19 | 2022-01-17 | Murray State (32) | 72 | 46 | Eastern Illinois (355) | Final | W | 26 |
| 20 | 2022-01-20 | Eastern Illinois (314) | 51 | 91 | Murray State (116) | Final | W | 40 |
| 21 | 2022-01-22 | Tennessee-Martin (205) | 66 | 74 | Murray State (116) | Final | W | 8 |
| 22 | 2022-01-24 | Tennessee Tech (310) | 53 | 79 | Murray State (116) | Final | W | 26 |
| 23 | 2022-01-27 | Murray State (116) | 80 | 75 | Tennessee Tech (310) | Final | W | 5 |
| 24 | 2022-01-29 | Morehead State (233) | 66 | 77 | Murray State (116) | Final | W | 11 |
| 25 | 2022-02-03 | Murray State (116) | 65 | 53 | Austin Peay (138) | Final | W | 12 |
| 26 | 2022-02-05 | SIU-Edwardsville (248) | 59 | 79 | Murray State (116) | Final | W | 20 |
| 27 | 2022-02-10 | Murray State (116) | 73 | 62 | Tennessee State (165) | Final | W | 11 |
| 28 | 2022-02-12 | Murray State (116) | 57 | 53 | Morehead State (233) | Final | W | 4 |
| 29 | 2022-02-17 | Austin Peay (138) | 56 | 91 | Murray State (116) | Final | W | 35 |
| 30 | 2022-02-19 | Murray State (26) | 62 | 60 | Tennessee-Martin (321) | Final | W | 2 |
| 31 | 2022-02-24 | Belmont (51) | 43 | 76 | Murray State (23) | Final | W | 33 |
| 32 | 2022-02-26 | Murray State (23) | 70 | 68 | Southeast Missouri State (298) | Final | W | 2 |
| 33 | 2022-03-04 | Southeast Missouri State (288) | 74 | 88 | Murray State (22) | Final | W | 14 |
| 34 | 2022-03-05 | Morehead State (146) | 67 | 71 | Murray State (22) | Final | W | 4 |
| 35 | 2022-03-17 | San Francisco (33) | 87 | 92 | Murray State (20) | Final (OT) | W | 5 |
| 36 | 2022-03-19 | Saint Peter's (128) | 70 | 60 | Murray State (20) | Final | L | -10 |