Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Wooster | 60 | 94 | Chattanooga (133) | Final | W | 34 |
| 2 | 2021-11-09 | Chattanooga (133) | 75 | 64 | Loyola Marymount (84) | Final | W | 11 |
| 3 | 2021-11-14 | UNC-Asheville (244) | 45 | 75 | Chattanooga (291) | Final | W | 30 |
| 4 | 2021-11-16 | Tennessee Tech (234) | 62 | 69 | Chattanooga (56) | Final | W | 7 |
| 5 | 2021-11-20 | Chattanooga (291) | 56 | 54 | Virginia Commonwealth (38) | Final | W | 2 |
| 6 | 2021-11-23 | Covenant | 39 | 100 | Chattanooga (35) | Final | W | 61 |
| 7 | 2021-11-27 | Charleston (130) | 68 | 66 | Chattanooga (35) | Final | L | -2 |
| 8 | 2021-11-30 | Chattanooga (61) | 82 | 65 | Tennessee Tech (222) | Final | W | 17 |
| 9 | 2021-12-05 | Chattanooga (61) | 85 | 64 | Lipscomb (198) | Final | W | 21 |
| 10 | 2021-12-08 | Chattanooga (45) | 78 | 73 | UNC-Asheville (135) | Final | W | 5 |
| 11 | 2021-12-12 | Tennessee Wesleyan | 55 | 104 | Chattanooga (291) | Final | W | 49 |
| 12 | 2021-12-15 | Chattanooga (291) | 68 | 76 | Belmont (68) | Final | L | -8 |
| 13 | 2021-12-18 | Chattanooga (291) | 76 | 87 | Murray State (116) | Final | L | -11 |
| 14 | 2021-12-22 | Middle Tennessee (164) | 65 | 77 | Chattanooga (291) | Final | W | 12 |
| 15 | 2021-12-30 | East Tennessee State (140) | 52 | 82 | Chattanooga (291) | Final | W | 30 |
| 16 | 2022-01-01 | Chattanooga (291) | 0 | 0 | Mercer (174) | Postponed | - | - |
| 17 | 2022-01-05 | Chattanooga (291) | 75 | 67 | Wofford (221) | Final | W | 8 |
| 18 | 2022-01-08 | The Citadel (332) | 67 | 85 | Chattanooga (291) | Final | W | 18 |
| 19 | 2022-01-12 | Chattanooga (48) | 59 | 70 | Western Carolina (256) | Final | L | -11 |
| 20 | 2022-01-15 | Furman (157) | 69 | 71 | Chattanooga (291) | Final | W | 2 |
| 21 | 2022-01-20 | Chattanooga (291) | 72 | 64 | UNC-Greensboro (265) | Final | W | 8 |
| 22 | 2022-01-22 | Chattanooga (291) | 78 | 74 | Virginia Military (357) | Final | W | 4 |
| 23 | 2022-01-26 | Wofford (136) | 60 | 71 | Chattanooga (61) | Final | W | 11 |
| 24 | 2022-01-29 | Chattanooga (291) | 75 | 62 | The Citadel (332) | Final | W | 13 |
| 25 | 2022-02-02 | Chattanooga (55) | 72 | 80 | Samford (200) | Final | L | -8 |
| 26 | 2022-02-05 | Mercer (174) | 68 | 77 | Chattanooga (291) | Final | W | 9 |
| 27 | 2022-02-07 | Chattanooga (291) | 74 | 72 | Mercer (174) | Final/OT | W | 2 |
| 28 | 2022-02-09 | Western Carolina (223) | 47 | 65 | Chattanooga (291) | Final | W | 18 |
| 29 | 2022-02-12 | Chattanooga (291) | 64 | 58 | Furman (157) | Final | W | 6 |
| 30 | 2022-02-17 | UNC-Greensboro (265) | 73 | 70 | Chattanooga (291) | Final | L | -3 |
| 31 | 2022-02-19 | Virginia Military (153) | 80 | 75 | Chattanooga (59) | Final | L | -5 |
| 32 | 2022-02-23 | Chattanooga (78) | 83 | 77 | East Tennessee State (175) | Final | W | 6 |
| 33 | 2022-02-26 | Samford (158) | 57 | 70 | Chattanooga (78) | Final | W | 13 |
| 34 | 2022-03-05 | The Citadel (235) | 66 | 71 | Chattanooga (69) | Final | W | 5 |
| 35 | 2022-03-06 | Wofford (125) | 56 | 79 | Chattanooga (67) | Final | W | 23 |
| 36 | 2022-03-07 | Furman (98) | 63 | 64 | Chattanooga (67) | Final | W | 1 |
| 37 | 2022-03-18 | Chattanooga (65) | 53 | 54 | Illinois (19) | Final | L | -1 |