Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | St. Thomas | 72 | 77 | Chicago State (346) | Final | W | 5 |
| 2 | 2021-11-12 | SIU-Edwardsville (248) | 56 | 67 | Chicago State (351) | Final | W | 11 |
| 3 | 2021-11-16 | Chicago State (58) | 56 | 92 | Loyola-Chicago (40) | Final | L | -36 |
| 4 | 2021-11-20 | Chicago State (351) | 50 | 81 | UC-Santa Barbara (171) | Final | L | -31 |
| 5 | 2021-11-22 | Chicago State (351) | 58 | 74 | Pacific (132) | Final | L | -16 |
| 6 | 2021-11-28 | Chicago State (302) | 57 | 75 | Bowling Green (267) | Final | L | -18 |
| 7 | 2021-12-01 | Chicago State (351) | 64 | 78 | Loyola-Maryland (325) | Final | L | -14 |
| 8 | 2021-12-04 | Tennessee State (165) | 49 | 59 | Chicago State (351) | Final | W | 10 |
| 9 | 2021-12-11 | Illinois State (94) | 81 | 71 | Chicago State (351) | Final | L | -10 |
| 10 | 2021-12-11 | Illinois State (268) | 80 | 71 | Chicago State (302) | Final | L | -9 |
| 11 | 2021-12-13 | Northern Illinois (326) | 70 | 59 | Chicago State (351) | Final | L | -11 |
| 12 | 2021-12-16 | Chicago State (351) | 61 | 55 | IU-Indy (338) | Final | W | 6 |
| 13 | 2021-12-16 | Chicago State (293) | 61 | 55 | IUPUI (357) | Final | W | 6 |
| 14 | 2021-12-21 | Chicago State (351) | 48 | 79 | Iowa State (7) | Final | L | -31 |
| 15 | 2021-12-22 | Chicago State (351) | 50 | 87 | Drake (217) | Final | L | -37 |
| 16 | 2021-12-30 | Chicago State (351) | 63 | 80 | Grand Canyon (74) | Final | L | -17 |
| 17 | 2022-01-01 | Chicago State (351) | 61 | 78 | New Mexico State (207) | Final | L | -17 |
| 18 | 2022-01-06 | Seattle (118) | 93 | 77 | Chicago State (351) | Final | L | -16 |
| 19 | 2022-01-08 | California Baptist (97) | 56 | 58 | Chicago State (351) | Final | W | 2 |
| 20 | 2022-01-13 | Chicago State (351) | 63 | 85 | UTRGV (161) | Final | L | -22 |
| 21 | 2022-01-15 | Chicago State (351) | 67 | 56 | Lamar (279) | Final | W | 11 |
| 22 | 2022-01-27 | Utah Valley (91) | 101 | 87 | Chicago State (351) | Final | L | -14 |
| 23 | 2022-01-29 | Dixie State (251) | 79 | 65 | Chicago State (334) | Final | L | -14 |
| 24 | 2022-02-02 | Chicago State (334) | 73 | 77 | Abilene Christian (137) | Final | L | -4 |
| 25 | 2022-02-05 | Chicago State (351) | 54 | 57 | Tarleton State (234) | Final | L | -3 |
| 26 | 2022-02-10 | Stephen F. Austin (88) | 81 | 61 | Chicago State (351) | Final | L | -20 |
| 27 | 2022-02-12 | Sam Houston State (120) | 72 | 59 | Chicago State (351) | Final | L | -13 |
| 28 | 2022-02-16 | Chicago State (337) | 71 | 88 | Stephen F. Austin (129) | Final | L | -17 |
| 29 | 2022-02-19 | Tarleton State (229) | 79 | 60 | Chicago State (337) | Final | L | -19 |
| 30 | 2022-02-23 | Grand Canyon (108) | 85 | 64 | Chicago State (340) | Final | L | -21 |
| 31 | 2022-02-26 | New Mexico State (62) | 59 | 61 | Chicago State (340) | Final | W | 2 |
| 32 | 2022-03-02 | Chicago State (333) | 53 | 62 | California Baptist (213) | Final | L | -9 |
| 33 | 2022-03-05 | Chicago State (333) | 66 | 74 | Seattle (113) | Final | L | -8 |
| 34 | 2022-03-08 | Chicago State (335) | 47 | 69 | Utah Valley (119) | Final | L | -22 |